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Novel diagnostic and therapeutic approach to inflammatory bowel disease based on functional characterization of patients: the CrUCCial index

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Publications

Biopsy-derived Intestinal Epithelial Cell Cultures for Pathway-based Stratification of Patients With Inflammatory Bowel Disease

Author(s): Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Manuel Noben, Sebastiaan De Schepper, Gert Van Assche, Marc Ferrante, Séverine Vermeire
Published in: Journal of Crohn's and Colitis, Issue 12/2, 2017, Page(s) 178-187, ISSN 1873-9946
DOI: 10.1093/ecco-jcc/jjx122

Genetic and Transcriptomic Bases of Intestinal Epithelial Barrier Dysfunction in Inflammatory Bowel Disease

Author(s): Maaike Vancamelbeke, Tim Vanuytsel, Ricard Farré, Sare Verstockt, Marc Ferrante, Gert Van Assche, Paul Rutgeerts, Frans Schuit, Séverine Vermeire, Ingrid Arijs, Isabelle Cleynen
Published in: Inflammatory Bowel Diseases, Issue 23/10, 2017, Page(s) 1718-1729, ISSN 1078-0998
DOI: 10.1097/MIB.0000000000001246

Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology

Author(s): Manuel Noben, Wiebe Vanhove, Kaline Arnauts, Anabela Santo Ramalho, Gert Van Assche, Séverine Vermeire, Catherine Verfaillie, Marc Ferrante
Published in: United European Gastroenterology Journal, Issue 5/8, 2017, Page(s) 1073-1081, ISSN 2050-6406
DOI: 10.1177/2050640617722903

The intestinal barrier: a fundamental role in health and disease

Author(s): Maaike Vancamelbeke, Séverine Vermeire
Published in: Expert Review of Gastroenterology & Hepatology, Issue 11/9, 2017, Page(s) 821-834, ISSN 1747-4124
DOI: 10.1080/17474124.2017.1343143

Butyrate does not protect against inflammation-induced loss of epithelial barrier function and cytokine production in primary cell monolayers from patients with ulcerative colitis

Author(s): Maaike Vancamelbeke, Thessa Laeremans, Wiebe Vanhove, Kaline Arnauts, Anabela Santo Ramalho, Ricard Farré, Isabelle Cleynen, Marc Ferrante, Séverine Vermeire
Published in: Journal of Crohn's and Colitis, 2019, ISSN 1873-9946
DOI: 10.1093/ecco-jcc/jjz064

Low TREM1 expression in whole blood predicts anti-TNF response in inflammatory bowel disease

Author(s): Bram Verstockt, Sare Verstockt, Jonas Dehairs, Vera Ballet, Helene Blevi, Willem-Jan Wollants, Christine Breynaert, Gert Van Assche, Séverine Vermeire, Marc Ferrante
Published in: EBioMedicine, Issue 40, 2019, Page(s) 733-742, ISSN 2352-3964
DOI: 10.1016/j.ebiom.2019.01.027

Mucosal IL13RA2 expression predicts nonresponse to anti-TNF therapy in Crohn's disease

Author(s): Bram Verstockt, Sare Verstockt, Brecht Creyns, Sophie Tops, Gert Van Assche, Ann Gils, Jan L. Ceuppens, Séverine Vermeire, Marc Ferrante, Christine Breynaert
Published in: Alimentary Pharmacology & Therapeutics, Issue 49/5, 2019, Page(s) 572-581, ISSN 0269-2813
DOI: 10.1111/apt.15126

Tu1862 Profiling of the Fecal Microbiota and Metabolome in Patients with Inflammatory Bowel Disease and their Unaffected Relatives

Author(s): Maaike Vancamelbeke, João Sabino, Lise Deroover, Greet Vandermeulen, Anja Luypaerts, Marc Ferrante, Gwen Falony, Sara Vieira-Silva, Kristin Verbeke, Jeroen Raes, Isabelle Cleynen, Severine Vermeire
Published in: Gastroenterology, Issue 152/5, 2017, Page(s) S991, ISSN 0016-5085

Tu1770 Genetic Defects in ER Stress and Autophagy Translate Into Increased Functional ER Stress Levels in Patients with Inflammatory Bowel Disease

Author(s): Wiebe Vanhove, Kris Nys, Ingrid Arijs, Isabelle Cleynen, Magali de Bruyn, Hannelie Korf, Marc Ferrante, Gert A. Van Assche, Severine Vermeire
Published in: Gastroenterology, Issue 152/5, 2017, Page(s) S963-S964, ISSN 0016-5085

Tu1856: Impact of Ileocecal Resection in Crohn's Disease Patients on Fecal Microbiota

Author(s): Kathleen Machiels, Victoria Pascal, João Sabino, Alba Santiago, David Campos, Albert Wolthuis, Anthony de Buck van Overstraeten, Andre D'Hoore, Gert A. Van Assche, Marc Ferrante, Paul Rutgeerts, Chaysavanh Manichanh, Severine Vermeire
Published in: Gastroenterology, Issue 152/5, 2017, Page(s) S989-S990, ISSN 0016-5085

P084 Ileal gene expression changes are associated with colonic disease activity in patients with ulcerative colitis

Author(s): M Vancamelbeke, S Verstockt, M Ferrante, G Van Assche, S Vermeire, I Cleynen
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S134-S136, ISSN 1873-9946

P117 Serum proteomic analysis characterises newly diagnosed Crohn’s disease and ulcerative colitis depending on the age at diagnosis

Author(s): S Verstockt, E Glorieus, M De Decker, B Verstockt, N Ardeshir Davani, V Ballet, G Van Assche, P Hindryckx, M Ferrante, D Laukens, F Mana, M De Vos, S Vermeire, I Cleynen
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S151-S152, ISSN 1873-9946

P854 Quantitative microbiome profiling changes the described dysbiotic state in inflammatory bowel disease

Author(s): C Caenepeel, S Vieira-Silva, J Sabino, K Machiels, G Falony, M Ferrante, G Van Assche, J Raes, S Vermeire
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S548-S549, ISSN 1873-9946

OP003 Temporal changes in immune pathways with consecutive biological therapies as measured by serum proteomics

Author(s): M de Bruyn, V Ballet, S Verstockt, B Verstockt, G Van Assche, M Ferrante, K Machiels, S Vermeire
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S003-S003, ISSN 1873-9946

P104 Gene expression profiles in inflamed colonic biopsies from newly diagnosed Crohn’s disease and ulcerative colitis patients differ depending on the age at diagnosis

Author(s): S Verstockt, B Verstockt, J Van Bouwel, W Meert, A Cortes Calabuig, V Brys, V Ballet, E Glorieus, M De Decker, G Van Assche, P Hindryckx, M Ferrante, D Laukens, F Mana, M De Vos, S Vermeire, I Cleynen
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S146-S146, ISSN 1873-9946

Tu1857: Mucosal Recolonization after Ileocecal Resection Differs in Crohn's Disease Patients Developing Postoperative Recurrence

Author(s): Kathleen Machiels, Marta Pozuelo del Río, João Sabino, Alba Santiago, David Campos, Albert Wolthuis, Anthony de Buck van Overstraeten, Andre D'Hoore, Gert A. Van Assche, Marc Ferrante, Paul Rutgeerts, Gert De Hertogh, Severine Vermeire, Chaysavanh Manichanh
Published in: Gastroenterology, Issue 152/5, 2017, Page(s) S990, ISSN 0016-5085

P042 Decreased leukocyte trafficking may contribute to vedolizumab refractory disease after anti-TNF exposure in patients with ulcerative colitis

Author(s): B Verstockt, S Verstockt, M de Bruyn, K Machiels, H Blevi, V Ballet, G Van Assche, S Vermeire, M Ferrante
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S113-S113, ISSN 1873-9946

P052 Protein biomarkers identify subclinical inflammation patterns in first-degree relatives of patients with inflammatory bowel disease

Author(s): M Vancamelbeke, V Ballet, N Ardeshir Davani, G Van Assche, M Ferrante, I Cleynen, S Vermeire
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S118-S119, ISSN 1873-9946

P010 Serum proteomic profiling in Crohn’s disease patients undergoing ileocolonic resection reveals discriminative inflammatory markers for endoscopic recurrence

Author(s): K Machiels, M de Bruyn, S Verstockt, B Verstockt, G Van Assche, A Wolthuis, A d'Hoore, M Ferrante, S Vermeire
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S096-S097, ISSN 1873-9946

P035 Serum markers predict outcome to ustekinumab in patients with refractory Crohn’s disease and provide insides in the mechanism of action

Author(s): B Verstockt, S Vermeire, S Verstockt, B Creyns, N Ardeshir Davani, C Breynaert, G Van Assche, G Van Assche, M Ferrante
Published in: Journal of Crohn's and Colitis, Issue 12/supplement_1, 2018, Page(s) S110-S110, ISSN 1873-9946

Tu1799 - Serum Proteomic Profiling Reveals Changes in Inflammatory Profiles with Consecutive Biological Therapies in Patients with Inflammatory Bowel Disease

Author(s): Magali de Bruyn, Vera Ballet, Sare Verstockt, Bram Verstockt, Gert A. Van Assche, Marc Ferrante, Kathleen Machiels, Severine Vermeire
Published in: Gastroenterology, Issue 154/6, 2018, Page(s) S-1023, ISSN 0016-5085

P774 Metagenomics and metabolomics of patients with inflammatory bowel disease and their unaffected relatives

Author(s): M. Vancamelbeke, J. Sabino, L. Deroover, G. Vandermeulen, A. Luypaerts, M. Ferrante, G. Falony, S. Vieira-Silva, K. Verbeke, J. Raes, I. Cleynen, S. Vermeire
Published in: Journal of Crohn's and Colitis, Issue 11/suppl_1, 2017, Page(s) S476-S477, ISSN 1873-9946

Sa1784 - Unaffected First-Degree Relatives of Patients with Inflammatory Bowel Disease have Altered Profiles of Inflammation-Related Proteins

Author(s): Maaike Vancamelbeke, Vera Ballet, Nooshin Ardeshir Davani, Gert A. Van Assche, Marc Ferrante, Isabelle Cleynen, Severine Vermeire
Published in: Gastroenterology, Issue 154/6, 2018, Page(s) S-393, ISSN 0016-5085

Tu1808 - Colonic Inflammation Determines Ileal Gene Expression Changes in Ulcerative Colitis

Author(s): Maaike Vancamelbeke, Sare Verstockt, Marc Ferrante, Gert A. Van Assche, Severine Vermeire, Isabelle Cleynen
Published in: Gastroenterology, Issue 154/6, 2018, Page(s) S-1025-S-1026, ISSN 0016-5085

Su1794 - Discrimination of Endoscopic Postoperative Recurrence in Patients with Crohn's Disease using Serological Inflammatory Markers

Author(s): Kathleen Machiels, Magali de Bruyn, Sare Verstockt, Bram Verstockt, Gert A. Van Assche, Albert Wolthuis, Andre D'Hoore, Marc Ferrante, Severine Vermeire
Published in: Gastroenterology, Issue 154/6, 2018, Page(s) S-586-S-587, ISSN 0016-5085

OP038 Impact of ileocecal resection in Crohn's disease patients on mucosal microbiota

Author(s): K. Machiels, M. Pozuelo del Río, J. Sabino, A. Santiago, D. Campos, A. Wolthuis, A. De Buck van Overstraeten, A. D'Hoore, G. Van Assche, M. Ferrante, P. Rutgeerts, G. De Hertogh, S. Vermeire, C. Manichanh
Published in: Journal of Crohn's and Colitis, Issue 11/suppl_1, 2017, Page(s) S24-S25, ISSN 1873-9946

DOP044 Relationship between microbiota and development of early postoperative Crohn's disease recurrence

Author(s): K. Machiels, V. Pascal, J. Sabino, A. Santiago, D. Campos, A. Wolthuis, A. De Buck van Overstraeten, A. D'Hoore, G. Van Assche, M. Ferrante, P. Rutgeerts, C. Manichanh, S. Vermeire
Published in: Journal of Crohn's and Colitis, Issue 11/suppl_1, 2017, Page(s) S53-S53, ISSN 1873-9946

OP30 Serum proteomic profiling predicts and diagnoses pouchitis in ulcerative colitis patients undergoing ileal pouch-anal anastomosis

Author(s): K Machiels, M Ferrante, N Davani, A Wolthuis, A D’Hoore, S Vermeire
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S022-S023, ISSN 1873-9946

DOP70 An integrated multi-omics biomarker predicting endoscopic response in ustekinumab treated patients with Crohn's disease

Author(s): B Verstockt, P Sudahakar, B Creyns, S Verstockt, J Cremer, W-J Wollants, S Organe, T Korcsmaros, M Madgwick, G Van Assche, C Breynaert, S Vermeire, M Ferrante
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S072-S073, ISSN 1873-9946

DOP38 A vedolizumab specific four-gene colonic signature accurately predicting future endoscopic remission in patients with inflammatory bowel disease

Author(s): B Verstockt, S Verstockt, P Sudahakar, J Dehairs, H Blevi, G Van Assche, S Vermeire, M Ferrante
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S048-S048, ISSN 1873-9946

P385 TREM1, the first anti-TNF specific biomarker guiding therapeutic decision

Author(s): B Verstockt, S Verstockt, J Dehairs, V Ballet, H Blevi, W-J Wollants, C Breynaert, G Van Assche, S Vermeire, M Ferrante
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S300-S300, ISSN 1873-9946

P001 Multi-omic data integration assisted identification of molecular features contributing to disease heterogeneity in Crohn's disease

Author(s): P Sudhakar, B Verstockt, B Creyns, J Cremer, G van Assche, T Korcsmaros, M Ferrante, S Vermeire
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S085-S086, ISSN 1873-9946

Sa1781 - Serological Markers Define Newly Diagnosed Crohn's Disease and Ulcerative Colitis Based on the age at Diagnosis

Author(s): Sare Verstockt, Elien Glorieus, Muriel De Decker, Bram Verstockt, Nooshin Ardeshir Davani, Vera Ballet, Gert A. Van Assche, Pieter Hindryckx, Marc Ferrante, Debby Laukens, Fazia Mana, Martine De Vos, Severine Vermeire, Isabelle Cleynen
Published in: Gastroenterology, Issue 154/6, 2018, Page(s) S-392, ISSN 0016-5085

OP10 Systems genomics of ulcerative colitis: combining GWAS and signalling networks for patient stratification and individualised drug targeting in ulcerative colitis

Author(s): J Brooks, D Modos, P Sudhakar, D Fazekas, A Zoufir, A Watson, M Tremelling, B Verstockt, S Vermeire, A Bender, S Carding, T Korcsmaros
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S006-S007, ISSN 1873-9946

P821 Distinct and common gene expression profiles between inflamed ileum and colon of newly diagnosed CD patients

Author(s): S Verstockt, F Ver Donck, B Verstockt, M Vancamelbeke, M De Decker, E Glorieus, V Ballet, G Van Assche, D Laukens, M Ferrante, F Mana, M De Vos, S Vermeire, I Cleynen
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S533-S533, ISSN 1873-9946

Tu1810 - Transcriptomic Profile of Inflamed Colonic Biopsies from Newly Diagnosed Crohn's Disease and Ulcerative Colitis Patients Depend on the age at Diagnosis

Author(s): Sare Verstockt, Bram Verstockt, Jens Van Bouwel, Wim Meert, Alvaro Cortés Calabuig, Vanessa Brys, Vera Ballet, Elien Glorieus, Muriel De Decker, Gert A. Van Assche, Pieter Hindryckx, Marc Ferrante, Debby Laukens, Fazia Mana, Martine De Vos, Severine Vermeire, Isabelle Cleynen
Published in: Gastroenterology, Issue 154/6, 2018, Page(s) S-1026, ISSN 0016-5085

P827 Up-regulation of IL17-related pathways in affected colon from ulcerative colitis compared with Crohn’s disease

Author(s): S Verstockt, F Ver Donck, B Verstockt, E Glorieus, M De Decker, V Ballet, G Van Assche, D Laukens, M Ferrante, F Mana, M De Vos, S Vermeire, I Cleynen
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S537-S538, ISSN 1873-9946

P836 The predictive role of gut microbiota in treatment response to vedolizumab and ustekinumab in inflammatory bowel disease

Author(s): C Caenepeel, S Vieira-Silva, B Verstockt, M Ferrante, J Raes, S Vermeire
Published in: Journal of Crohn's and Colitis, Issue 13/Supplement_1, 2019, Page(s) S542-S542, ISSN 1873-9946