Community Research and Development Information Service - CORDIS

H2020

MECHANO-CONTROL

Project ID: 731957
Funded under

Mechanical control of biological function

From 2017-01-01 to 2021-12-31, ongoing project | MECHANO-CONTROL Website

Project details

Total cost:

EUR 7 134 928,75

EU contribution:

EUR 7 134 928,75

Coordinated in:

Spain

Call for proposal:

FETPROACT-2016See other projects for this call

Funding scheme:

RIA - Research and Innovation action

Objective

Deliverables

Publications

  • "NatB-mediated protein N-α-terminal acetylation is a potential therapeutic target in hepatocellular carcinoma"
    Author(s): Leire Neri, Marta Lasa, Alberto Elosegui-Artola, Delia D'Avola, Beatriz Carte, Cristina Gazquez, Sara Alve, Pere Roca-Cusachs, Mercedes Iñarrairaegui, Jose Herrero, Jesús Prieto, Bruno Sangro, Rafael Aldabe
    Published in: Oncotarget, issue 8/25, 2017.  ISSN: 1949-2553
    DOI: 10.18632/oncotarget.17332
  • Force loading explains spatial sensing of ligands by cells
    Author(s): Roger Oria, Tina Wiegand, Jorge Escribano, Alberto Elosegui-Artola, Juan Jose Uriarte, Cristian Moreno-Pulido, Ilia Platzman, Pietro Delcanale, Lorenzo Albertazzi, Daniel Navajas, Xavier Trepat, José Manuel García-Aznar, Elisabetta Ada Cavalcanti-Adam, Pere Roca-Cusachs
    Published in: Nature, 2017.  ISSN: 0028-0836
    DOI: 10.1038/nature24662
  • The force-dependent mechanism of DnaK-mediated mechanical folding
    Author(s): Judit Perales-Calvo, David Giganti, Guillaume Stirnemann, Sergi Garcia-Manyes
    Published in: Science Advances, issue 4/2, 2018. Page(s) eaaq0243.  ISSN: 2375-2548
    DOI: 10.1126/sciadv.aaq0243
  • Molecular clutch drives cell response to surface viscosity
    Author(s): Mark Bennett, Marco Cantini, Julien Reboud, Jonathan M. Cooper, Pere Roca-Cusachs, Manuel Salmeron-Sanchez
    Published in: Proceedings of the National Academy of Sciences, issue 115/6, 2018. Page(s) 1192-1197.  ISSN: 0027-8424
    DOI: 10.1073/pnas.1710653115
  • Long-lived force patterns and deformation waves at repulsive epithelial boundaries
    Author(s): Pilar Rodríguez-Franco, Agustí Brugués, Ariadna Marín-Llauradó, Vito Conte, Guiomar Solanas, Eduard Batlle, Jeffrey J. Fredberg, Pere Roca-Cusachs, Raimon Sunyer, Xavier Trepat
    Published in: Nature Materials, issue 16/10, 2017. Page(s) 1029-1037.  ISSN: 1476-1122
    DOI: 10.1038/NMAT4972
  • Amoebae as Mechanosensitive Tanks
    Author(s): Alberto Elosegui-Artola, Pere Roca-Cusachs
    Published in: Biophysical Journal, issue 112/12, 2017. Page(s) 2457-2458.  ISSN: 0006-3495
    DOI: 10.1016/j.bpj.2017.05.020
  • Quantifying forces in cell biology
    Author(s): Pere Roca-Cusachs, Vito Conte, Xavier Trepat
    Published in: Nature Cell Biology, issue 19/7, 2017. Page(s) 742-751.  ISSN: 1465-7392
    DOI: 10.1038/ncb3564
  • A mechanically active heterotypic E-cadherin/N-cadherin adhesion enables fibroblasts to drive cancer cell invasion
    Author(s): Anna Labernadie, Takuya Kato, Agustí Brugués, Xavier Serra-Picamal, Stefanie Derzsi, Esther Arwert, Anne Weston, Victor González-Tarragó, Alberto Elosegui-Artola, Lorenzo Albertazzi, Jordi Alcaraz, Pere Roca-Cusachs, Erik Sahai, Xavier Trepat
    Published in: Nature Cell Biology, issue 19/3, 2017. Page(s) 224-237.  ISSN: 1465-7392
    DOI: 10.1038/ncb3478
  • Binding of ZO-1 to α5β1 integrins regulates the mechanical properties of α5β1–fibronectin links
    Author(s): Víctor González-Tarragó, Alberto Elosegui-Artola, Elsa Bazellières, Roger Oria, Carlos Pérez-González, Pere Roca-Cusachs
    Published in: Molecular Biology of the Cell, issue 28/14, 2017. Page(s) 1847-1852.  ISSN: 1059-1524
    DOI: 10.1091/mbc.E17-01-0006
  • Force Triggers YAP Nuclear Entry by Regulating Transport across Nuclear Pores
    Author(s): Alberto Elosegui-Artola, Ion Andreu, Amy E.M. Beedle, Ainhoa Lezamiz, Marina Uroz, Anita J. Kosmalska, Roger Oria, Jenny Z. Kechagia, Palma Rico-Lastres, Anabel-Lise Le Roux, Catherine M. Shanahan, Xavier Trepat, Daniel Navajas, Sergi Garcia-Manyes, Pere Roca-Cusachs
    Published in: Cell, issue 171/6, 2017. Page(s) 1397-1410.e14.  ISSN: 0092-8674
    DOI: 10.1016/j.cell.2017.10.008
  • Membrane tension controls adhesion positioning at the leading edge of cells
    Author(s): Bruno Pontes, Pascale Monzo, Laurent Gole, Anabel-Lise Le Roux, Anita Joanna Kosmalska, Zhi Yang Tam, Weiwei Luo, Sophie Kan, Virgile Viasnoff, Pere Roca-Cusachs, Lisa Tucker-Kellogg, Nils C. Gauthier
    Published in: The Journal of Cell Biology, 2017. Page(s) jcb.201611117.  ISSN: 0021-9525
    DOI: 10.1083/jcb.201611117

Coordinator

FUNDACIO INSTITUT DE BIOENGINYERIA DE CATALUNYA
Spain

EU contribution: EUR 1 763 750


CARRER BALDIRI REIXAC PLANTA 2A 10-12
08028 BARCELONA
Spain
Activity type: Research Organisations

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Participants

UNIVERSITAT POLITECNICA DE CATALUNYA
Spain

EU contribution: EUR 638 000


CALLE JORDI GIRONA 31
08034 BARCELONA
Spain
Activity type: Higher or Secondary Education Establishments

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LEIBNIZ-INSTITUT FUER NEUE MATERIALIEN GEMEINNUETZIGE GMBH
Germany

EU contribution: EUR 662 000


CAMPUS D2 2
66123 SAARBRUECKEN
Germany
Activity type: Research Organisations

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KING'S COLLEGE LONDON
United Kingdom

EU contribution: EUR 706 715


Strand
WC2R 2LS LONDON
United Kingdom
Activity type: Higher or Secondary Education Establishments

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UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands

EU contribution: EUR 2 337 450


HEIDELBERGLAAN 100
3584 CX UTRECHT
Netherlands
Activity type: Higher or Secondary Education Establishments

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MIND THE BYTE SL
Spain

EU contribution: EUR 316 513,75


CALLE MANSO 76 PRINCIPAL 1
08015 BARCELONA
Spain
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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NOVIOCELL BV
Netherlands

EU contribution: EUR 710 500


KLOOSTERSTRAAT 9 RE1131
5349 AB OSS
Netherlands
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)

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