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REgenerative therapy of intervertebral disc: a double blind phase 2b trial of intradiscal injection of mesenchymal stromal cells in degenerative disc disease of the lomber SPINE unresponsive to conventional therapy

Deliverables

Midterm recruitment report

Midterm recruitment report

Dissemination and Communication

CHUM will be prepared logo, poster, video, brochure and website

Report describing the profile of inflammatory markers and cytokine meditators that contribute to the inflammatory nature of the degenerated disc

Report describing the profile of inflammatory markers and cytokine meditators that contribute to the inflammatory nature of the degenerated disc

Registration of clinical trial on EudraCT and Clinicaltrials.gov

Registration of clinical trial on EudraCT and Clinicaltrials.gov. Transfer the register number to the european comission

Report describing the identification of inflammatory mediators capable of “licensing”: MSCs in vitro

Report describing the identification of inflammatory mediators capable of “licensing”: MSCs in vitro

Minutes of the Meeting with complementary projects

A Meeting with representatives from these and any other complementary projects will be set-up in M24 to discuss and exchange best-practices regarding scientific, standardisation, economic and regulatory issues related to projects’ results. Networking and exchange of best practices with similar initiatives will also take place throughout the project at conferences and other events.

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Publications

Mesenchymal Stem Cell-Derived Exosomes: The New Frontier for the Treatment of Intervertebral Disc Degeneration

Author(s): Veronica Tilotta, Gianluca Vadalà ,Luca Ambrosio, Fabrizio Russo, Claudia Cicione, Giuseppina Di Giacomo, Rocco Papalia andVincenzo Denaro
Published in: Applied Sciences, 2021, ISSN 2076-3417
Publisher: MDPI
DOI: 10.3390/app112311222

miR-155 Contributes to the Immunoregulatory Function of Human Mesenchymal Stem Cells

Author(s): Yves-Marie Pers, Claire Bony, Isabelle Duroux-Richard, Laurène Bernard, Marie Maumus, Said Assou, Frank Barry, Christian Jorgensen, Danièle Noël
Published in: Frontiers in Immunology, 12, 2021, ISSN 1664-3224
Publisher: frontiersin
DOI: 10.3389/fimmu.2021.624024

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Regulate the Mitochondrial Metabolism via Transfer of miRNAs

Author(s): Claire Loussouarn, Yves-Marie Pers, Claire Bony, Christian Jorgensen, Danièle Noël
Published in: Frontiers in Immunology, 12, 2021, ISSN 1664-3224
Publisher: frontiersin
DOI: 10.3389/fimmu.2021.623973

Combinatorial conditioning of adipose derived‐mesenchymal stem cells enhances their neurovascular potential: Implications for intervertebral disc degeneration

Author(s): Abbie. L. A. Binch, Stephen M. Richardson, Judith A. Hoyland, Frank P. Barry
Published in: JOR SPINE, 2/4, 2019, ISSN 2572-1143
Publisher: JOR SPINE
DOI: 10.1002/jsp2.1072

A Hyaluronan and Platelet-Rich Plasma Hydrogel for Mesenchymal Stem Cell Delivery in the Intervertebral Disc: An Organ Culture Study

Author(s): Fabrizio Russo, Luca Ambrosio, Marianna Peroglio, Wei Guo, Sebastian Wangler, Jan Gewiess, Sibylle Grad, Mauro Alini, Rocco Papalia, Gianluca Vadalà, Vincenzo Denaro
Published in: International Journal of Molecular Sciences, 22/6, 2021, Page(s) 2963, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22062963