Skip to main content

A Systems medicine approach to chronic inflammatory disease

Objective

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC ICGC, TwinsUK and Meta-HIT) to investigate human data sets on three major levels of resolution: whole blood signatures, signatures from purified immune cell types (with a focus on CD14 and CD4/CD8) and selected single cell level analyses. Principle data layers will comprise SNP variome, methylome, transcriptome and gut microbiome. SYSCID employs a dedicated data management infrastructure, strong algorithmic development groups (including an SME for exploitation of innovative software tools for data deconvolution) and will validate results in independent retrospective and prospective clinical cohorts.
Using this setup we will focus on three fundamental aims : (i) the identification of shared and unique ""core disease signatures” which are associated with the disease state and independent of temporal variation, (ii) the generation of ""predictive models of disease outcome""- builds on previous work that pathways/biomarkers for disease outcome are distinct from initial disease risk and may be shared across diseases to guide therapy decisions on an individual patient basis, (iii) ""reprogramming disease""- will identify and target temporally stable epigenetic alterations in macrophages and lymphocytes in epigenome editing approaches as biological validation and potential novel therapeutic tool .
Thus, SYSCID will foster the development of solid biomarkers and models as stratification in future long-term systems medicine clinical trials but also investigate new causative therapies by editing the epigenome code in specific immune cells, e.g. to alleviate macrophage polarization defects."

Call for proposal

H2020-SC1-2016-2017

See other projects for this call

Sub call

H2020-SC1-2016-RTD

Coordinator

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Net EU contribution
€ 2 851 760,00
Address
Olshausenstrasse 40
24118 Kiel
Germany
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Schleswig-Holstein Schleswig-Holstein Kiel, Kreisfreie Stadt

Participants (16)

KING'S COLLEGE LONDON
United Kingdom
Net EU contribution
€ 919 083,75
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
VIB VZW
Belgium
Net EU contribution
€ 1 181 518,75
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Vlaams Gewest Prov. Oost-Vlaanderen Arr. Gent
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
Net EU contribution
€ 1 061 022,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
East of England East Anglia Cambridgeshire CC
UNIVERSITE DE LIEGE
Belgium
Net EU contribution
€ 1 016 900,00
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITE DE GENEVE
Switzerland
Net EU contribution
€ 0,00
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 1 561 875,00
Region
Schweiz/Suisse/Svizzera Région lémanique Genève
COMMA SOFT AG
Germany
Net EU contribution
€ 348 125,00
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Putzchens Chaussee 202-204A
53229 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
 
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
Net EU contribution
€ 1 259 351,25
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Nordrhein-Westfalen Köln Bonn, Kreisfreie Stadt
UNIVERSITE DU LUXEMBOURG
Luxembourg
Net EU contribution
€ 1 117 540,00
Address
2 Avenue De L'universite
4365 Esch-sur-alzette
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
SYDDANSK UNIVERSITET
Denmark
Net EU contribution
€ 590 935,00
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAT DES SAARLANDES
Germany
Net EU contribution
€ 1 173 675,00
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
Region
Saarland Saarland Regionalverband Saarbrücken
HUMANITAS UNIVERSITY

Participation ended

Italy
Net EU contribution
€ 398 070,90
Address
Via Rita Levi Montalcini Snc
20090 Pieve Emanuele
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
Net EU contribution
€ 604 227,83
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
GENOS DOO ZA VJESTACENJE I ANALIZU
Croatia
Net EU contribution
€ 746 743,15
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Vatrogasna 112
31000 Osijek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Region
Hrvatska Panonska Hrvatska Osječko-baranjska županija
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

FACULTY OF SCIENCE UNIVERSITY OF ZAGREB
Croatia
Net EU contribution
€ 140 000,00
Address
Horvatovac 102/A
10000 Zagreb
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
Net EU contribution
€ 650 329,02
SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
Net EU contribution
€ 396 954,10
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00