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A Systems medicine approach to chronic inflammatory disease

Objective

"The SYSCID consortium aims to develop a systems medicine approach for disease prediction in CID. We will focus on three major CID indications with distinct characteristics, yet a large overlap of their molecular risk map: inflammatory bowel disease, systemic lupus erythematodes and rheumatoid arthritis. We have joined 15 partners from major cohorts and initiatives in Europe (e.g.IHEC, ICGC, TwinsUK and Meta-HIT) to investigate human data sets on three major levels of resolution: whole blood signatures, signatures from purified immune cell types (with a focus on CD14 and CD4/CD8) and selected single cell level analyses. Principle data layers will comprise SNP variome, methylome, transcriptome and gut microbiome. SYSCID employs a dedicated data management infrastructure, strong algorithmic development groups (including an SME for exploitation of innovative software tools for data deconvolution) and will validate results in independent retrospective and prospective clinical cohorts.
Using this setup we will focus on three fundamental aims : (i) the identification of shared and unique ""core disease signatures” which are associated with the disease state and independent of temporal variation, (ii) the generation of ""predictive models of disease outcome""- builds on previous work that pathways/biomarkers for disease outcome are distinct from initial disease risk and may be shared across diseases to guide therapy decisions on an individual patient basis, (iii) ""reprogramming disease""- will identify and target temporally stable epigenetic alterations in macrophages and lymphocytes in epigenome editing approaches as biological validation and potential novel therapeutic tool .
Thus, SYSCID will foster the development of solid biomarkers and models as stratification in future long-term systems medicine clinical trials but also investigate new causative therapies by editing the epigenome code in specific immune cells, e.g. to alleviate macrophage polarization defects."

Field of science

  • /natural sciences/computer and information sciences/software
  • /medical and health sciences/clinical medicine/gastroenterology/inflammatory bowel disease

Call for proposal

H2020-SC1-2016-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL
Address
Olshausenstrasse 40
24118 Kiel
Germany
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 854 260

Participants (15)

KING'S COLLEGE LONDON
United Kingdom
EU contribution
€ 919 083,75
Address
Strand
WC2R 2LS London
Activity type
Higher or Secondary Education Establishments
VIB VZW
Belgium
EU contribution
€ 1 181 518,75
Address
Rijvisschestraat 120
9052 Zwijnaarde - Gent
Activity type
Research Organisations
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 1 061 022,50
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE LIEGE
Belgium
EU contribution
€ 1 016 900
Address
Place Du 20 Aout 7
4000 Liege
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 0
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
COMMA SOFT AG
Germany
EU contribution
€ 348 125
Address
Putzchens Chaussee 202-204A
53229 Bonn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
RHEINISCHE FRIEDRICH-WILHELMS-UNIVERSITAT BONN
Germany
EU contribution
€ 1 259 351,25
Address
Regina Pacis Weg 3
53113 Bonn
Activity type
Higher or Secondary Education Establishments
UNIVERSITE DU LUXEMBOURG
Luxembourg
EU contribution
€ 1 115 040
Address
2 Avenue De L'universite
4365 Esch-sur-alzette
Activity type
Higher or Secondary Education Establishments
SYDDANSK UNIVERSITET
Denmark
EU contribution
€ 590 935
Address
Campusvej 55
5230 Odense M
Activity type
Higher or Secondary Education Establishments
UNIVERSITAT DES SAARLANDES
Germany
EU contribution
€ 1 173 675
Address
Campus
66123 Saarbrucken
Activity type
Higher or Secondary Education Establishments
HUMANITAS UNIVERSITY

Participation ended

Italy
EU contribution
€ 411 026,44
Address
Via Rita Levi Montalcini Snc
20090 Pieve Emanuele
Activity type
Higher or Secondary Education Establishments
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON
Greece
EU contribution
€ 604 227,50
Address
Soranou Efesiou 4
115 27 Athina
Activity type
Research Organisations
GENOS DOO ZA VJESTACENJE I ANALIZU
Croatia
EU contribution
€ 880 050
Address
Vatrogasna 112
31000 Osijek
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH
Germany
EU contribution
€ 657 022,50
Address
Heinrich-hertz-allee 1
66386 St Ingbert
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
ISTITUTO EUROPEO DI ONCOLOGIA SRL
Italy
EU contribution
€ 383 998,56
Address
Via Filodrammatici 10
20121 Milano
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)