Spatial organization of DNA repair within the nucleus

Project Information

3D-REPAIR

Grant agreement ID: 682939

DOI 10.3030/682939

Project closed

EC signature date 19 December 2016

Start date 1 March 2017

End date 30 April 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 750,00

EU contribution € 1 999 750,00

Coordinated by

THE UNIVERSITY OF SUSSEX
United Kingdom

Publications

Peer reviewed articles (5)

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation

Author(s): Indrajeet Ghodke, Michaela Remisova, Audrey Furst, Sinan Kilic, Bernardo Reina-San-Martin, Anna R Poetsch, Matthias Altmeyer, Evi Soutoglou
Published in: Molecular Cell, 2021, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.04.010

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks

Author(s): Pierre Caron, Tibor Pankotai, Wouter W Wiegant, Maxim A X Tollenaere, Audrey Furst, Celine Bonhomme, Angela Helfricht, Anton de Groot, Albert Pastink, Alfred C O Vertegaal, Martijn S Luijsterburg, Evi Soutoglou, Haico van Attikum
Published in: Genes and Development, 2019, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.321943.118

Heterochromatic repeat clustering imposes a physical barrier on homologous recombination to prevent chromosomal translocations

Author(s): Ioanna Mitrentsi, Jieqiong Lou, Adèle Kerjouan, John Verigos, Bernardo Reina-San-Martin, Elizabeth Hinde, Evi Soutoglou
Published in: Molecular Cell, 2022, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2022.03.033

Activation of homologous recombination in G1 preserves centromeric integrity

Author(s): Duygu Yilmaz, Audrey Furst, Karen Meaburn, Aleksandra Lezaja, Yanlin Wen, Matthias Altmeyer , Bernardo Reina-San-Martin , Evi Soutoglou
Published in: Nature, 2021, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04200-z

Transcription and mRNA export machineries SAGA and TREX-2 maintain monoubiquitinated H2B balance required for DNA repair.

Author(s): Evangelista FM, Maglott-Roth A, Stierle M, Brino L, Soutoglou E, Tora L
Published in: Journal of Cell Biology, 2018, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201803074