Elucidating the Molecular Mechanisms of Synthetic Saponin Adjuvants and Development of Novel Self-Adjuvanting Vaccines

Project Information

ADJUV-ANT VACCINES

Grant agreement ID: 716878

DOI 10.3030/716878

Project closed

EC signature date 20 December 2016

Start date 1 March 2017

End date 28 February 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 499 218,75

EU contribution € 1 499 218,75

Coordinated by

ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS
Spain

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Publications

Peer reviewed articles (6)

Advances in chemical probing of protein O-GlcNAc glycosylation: structural role and molecular mechanisms

Author(s): Abhijit Saha; Davide Bello; Alberto Fernández-Tejada
Published in: Chemical Society Reviews, Issue 4, 2021, ISSN 0306-0012
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0cs01275k

Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action

Author(s): Carlo Pifferi, Roberto Fuentes, Alberto Fernández-Tejada
Published in: Nature Reviews Chemistry, Issue 5/3, 2021, Page(s) 197-216, ISSN 2397-3358
Publisher: Nature Publishing Group
DOI: 10.1038/s41570-020-00244-3

Chemical synthesis and immunological evaluation of new generation multivalent anticancer vaccines based on a Tn antigen analogue

Author(s): Carlo Pifferi, Ane Ruiz-de-Angulo, David Goyard, Claire Tiertant, Nagore Sacristán, Diego Barriales, Nathalie Berthet, Juan Anguita, Olivier Renaudet, Alberto Fernández-Tejada
Published in: Chemical Science, Issue 11/17, 2020, Page(s) 4488-4498, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0sc00544d

Exploiting structure–activity relationships of QS-21 in the design and synthesis of streamlined saponin vaccine adjuvants

Author(s): Mattia Ghirardello, Ane Ruiz-de-Angulo, Nagore Sacristan, Diego Barriales, Jesús Jiménez-Barbero, Ana Poveda, Francisco Corzana, Juan Anguita, Alberto Fernández-Tejada
Published in: Chemical Communications, Issue 56/5, 2020, Page(s) 719-722, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9cc07781b

Design, synthesis, and initial immunological evaluation of glycoconjugates based on saponin adjuvants and the Tn antigen

Author(s): Roberto Fuentes; Leire Aguinagalde; Nagore Sacristán; Alberto Fernández-Tejada
Published in: Chemical Communications, Issue 3, 2021, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc04459a

Replacing the Rhamnose‐Xylose Moiety of QS‐21 with Simpler Terminal Disaccharide Units Attenuates Adjuvant Activity in Truncated Saponin Variants

Author(s): Roberto Fuentes, Ane Ruiz‐de‐Angulo, Nagore Sacristán, Claudio Daniel Navo, Gonzalo Jiménez‐Osés, Juan Anguita, Alberto Fernández‐Tejada
Published in: Chemistry – A European Journal, Issue 27/14, 2021, Page(s) 4731-4737, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202004705