Objective
Neural networks process sensory inputs into outputs that guide behavioral responses. The computations that take place can be complex, suggesting intricate circuit architecture. While we are starting to unravel the circuit components of a specific neural computation, the extraction of visual motion cues, we realize that the circuits are more complex than anticipated. Here, we aim to reveal the full microcircuitry of behaviorally relevant motion-detecting pathways with complex physiological properties.
To understand the network implementation of a critical computation, we are studying motion detection in Drosophila. A hallmark is the extraction of direction-selective (DS) signals, which is achieved by spatiotemporal correlations of inputs. Neurons that are sufficient to set up DS signals have been identified, but are often not behaviorally necessary, suggesting redundant circuits at minimum. We have isolated a core visual pathway that is required for behavioral responses to motion cues, but displays physiological properties that are not in line with current models of motion detection. Recent data also show that DS neurons have complex receptive fields. Further, single neuronal inputs feed into both ON and OFF pathways, which later converge to control the behavioral output. What are the microcircuits that shape such receptive fields? And how do individual neurons, or individual synaptic connections contribute to one specific pathway and what is their specific computational role? We will dissect how complex receptive field properties and behavior are shaped by individual neurons. Further, we will develop a new tool to conditionally inactivate specific synaptic connection, Flp-TEV. This will allow to determine how individual synapses contribute to distinct downstream circuit properties, and behavior. We are thus proposing to map the circuit architecture of a behaviorally relevant visual pathway and understand how complex microcircuits perform relevant computation
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences computer and information sciences artificial intelligence computational intelligence
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2016-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
55122 MAINZ
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.