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Microcircuitry of the Drosophila visual system

Objective

Neural networks process sensory inputs into outputs that guide behavioral responses. The computations that take place can be complex, suggesting intricate circuit architecture. While we are starting to unravel the circuit components of a specific neural computation, the extraction of visual motion cues, we realize that the circuits are more complex than anticipated. Here, we aim to reveal the full microcircuitry of behaviorally relevant motion-detecting pathways with complex physiological properties.
To understand the network implementation of a critical computation, we are studying motion detection in Drosophila. A hallmark is the extraction of direction-selective (DS) signals, which is achieved by spatiotemporal correlations of inputs. Neurons that are sufficient to set up DS signals have been identified, but are often not behaviorally necessary, suggesting redundant circuits at minimum. We have isolated a core visual pathway that is required for behavioral responses to motion cues, but displays physiological properties that are not in line with current models of motion detection. Recent data also show that DS neurons have complex receptive fields. Further, single neuronal inputs feed into both ON and OFF pathways, which later converge to control the behavioral output. What are the microcircuits that shape such receptive fields? And how do individual neurons, or individual synaptic connections contribute to one specific pathway and what is their specific computational role? We will dissect how complex receptive field properties and behavior are shaped by individual neurons. Further, we will develop a new tool to conditionally inactivate specific synaptic connection, Flp-TEV. This will allow to determine how individual synapses contribute to distinct downstream circuit properties, and behavior. We are thus proposing to map the circuit architecture of a behaviorally relevant visual pathway and understand how complex microcircuits perform relevant computation

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Keywords

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Programme(s)

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Topic(s)

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Funding Scheme

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ERC-STG - Starting Grant

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Call for proposal

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(opens in new window) ERC-2016-STG

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Host institution

JOHANNES GUTENBERG-UNIVERSITAT MAINZ
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 196 163,64
Address
SAARSTRASSE 21
55122 Mainz
Germany

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Region
Rheinland-Pfalz Rheinhessen-Pfalz Mainz, Kreisfreie Stadt
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 196 163,64

Beneficiaries (2)

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