Objective
The overall goal of this project is to develop a universal FRET-based toolkit for screening of drugs targeting microRNA (miRNA). Specific outcome will be a high-throughput assay for finding drugs targeting miRNA-96, a tumor-suppressing miRNA in pancreatic cancer cells. FRET is the technique of choice and recently, Prof. Marcus Wilhelmsson, Chalmers University of Technology (CHALMERS; project main supervisor) pioneered the development and photophysical characterization of fluorescent base analogues (FBAs) optimized for high-resolution FRET analysis of nucleic acid systems. There is an urgent need in pharmaceutical industry for an in vitro, cell-free, pre-miRNA-small molecule interaction high-throughput assay and also to increase the understanding of the nature of miRNAs. In this project, the unique FRET FBAs will be utilized to develop such assays and to provide new knowledge regarding miRNA structure, dynamics and interactions with other biological molecules or drugs. Apart from taking on the new research field stated above and developing my professional skills, I will bring in new competences to CHALMERS in RNA biochemistry (from the University of Warsaw and Max Planck Institute in Göttingen). Moreover, as part of my training, I will carry out research at AstraZeneca (AZ) and Gothenburg University (UGOT) through secondments. CHALMERS/AZ/UGOT have an established collaboration and I will take full advantage of their R&T capacities in order to gain interdisciplinary and intersectoral expertise as well as to master my skills in scientific communication, scientific writing, coordinating research projects, results exploitation, critical assessment, mentoring, supervision, presentation and networking with other researchers across the globe. This MSCA Postdoctoral Fellowship will help me reaching a position of professional maturity invaluable for starting up my own research group or taking leading roles in industrial R&D organizations.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: https://op.europa.eu/en/web/eu-vocabularies/euroscivoc.
- natural sciences biological sciences biochemistry biomolecules nucleic acids
- natural sciences biological sciences genetics RNA
- medical and health sciences clinical medicine oncology pancreatic cancer
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
412 96 GOTEBORG
Sweden
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.