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CD8+ T cell metabolism in anti-tumor response

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Publications

The Tumor Metabolic Microenvironment: Lessons from Lactate

Author(s): Juan C. García-Cañaveras, Li Chen, Joshua D. Rabinowitz
Published in: Cancer Research, Issue 79/13, 2019, Page(s) 3155-3162, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-18-3726

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

Author(s): Will Bailis, Justin A. Shyer, Jun Zhao, Juan Carlos Garcia Canaveras, Fatimah J. Al Khazal, Rihao Qu, Holly R. Steach, Piotr Bielecki, Omair Khan, Ruaidhri Jackson, Yuval Kluger, Louis J. Maher, Joshua Rabinowitz, Joe Craft, Richard A. Flavell
Published in: Nature, 2019, ISSN 0028-0836
DOI: 10.1038/s41586-019-1311-3

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 + T cell stemness and antitumor immunity

Author(s): Dalton Hermans, Sanjivan Gautam, Juan C. García-Cañaveras, Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Risa Ebina-Shibuya, Christopher Bleck, Leonard M. Neckers, Joshua D. Rabinowitz, Luca Gattinoni, Warren J. Leonard
Published in: Proceedings of the National Academy of Sciences, Issue 117/11, 2020, Page(s) 6047-6055, ISSN 0027-8424
DOI: 10.1073/pnas.1920413117

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Author(s): Juan C. García-Cañaveras, Olga Lancho, Gregory S. Ducker, Jonathan M. Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D. Rabinowitz
Published in: Leukemia, 2020, ISSN 0887-6924
DOI: 10.1038/s41375-020-0845-6

Serine Catabolism Feeds NADH when Respiration Is Impaired

Author(s): Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz
Published in: Cell Metabolism, Issue 31/4, 2020, Page(s) 809-821.e6, ISSN 1550-4131
DOI: 10.1016/j.cmet.2020.02.017

A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

Author(s): Jonathan M. Ghergurovich, Juan C. García-Cañaveras, Joshua Wang, Emily Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C. Britt, Marta Piqueras-Nebot, Mari Carmen Gomez-Cabrera, Agustín Lahoz, Jing Fan, Ulf H. Beier, Hahn Kim, Joshua D. Rabinowitz
Published in: Nature Chemical Biology, Issue 16/7, 2020, Page(s) 731-739, ISSN 1552-4450
DOI: 10.1038/s41589-020-0533-x