CD8+ T cell metabolism in anti-tumor response

Informazioni relative al progetto

Immunometabolomics

ID dell’accordo di sovvenzione: 751423

DOI 10.3030/751423

Progetto chiuso

Data della firma CE 14 Marzo 2017

Data di avvio 1 Luglio 2017

Data di completamento 30 Giugno 2020

Finanziato da

• EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions

Costo totale € 257 191,20

Contributo UE € 257 191,20

Coordinato da

FUNDACION PARA LA INVESTIGACION DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA
Spain

Pubblicazioni

Peer reviewed articles (6)

The Tumor Metabolic Microenvironment: Lessons from Lactate

Autori: Juan C. García-Cañaveras, Li Chen, Joshua D. Rabinowitz
Pubblicato in: Cancer Research, Numero 79/13, 2019, Pagina/e 3155-3162, ISSN 0008-5472
Editore: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-18-3726

Distinct modes of mitochondrial metabolism uncouple T cell differentiation and function

Autori: Will Bailis, Justin A. Shyer, Jun Zhao, Juan Carlos Garcia Canaveras, Fatimah J. Al Khazal, Rihao Qu, Holly R. Steach, Piotr Bielecki, Omair Khan, Ruaidhri Jackson, Yuval Kluger, Louis J. Maher, Joshua Rabinowitz, Joe Craft, Richard A. Flavell
Pubblicato in: Nature, 2019, ISSN 0028-0836
Editore: Nature Publishing Group
DOI: 10.1038/s41586-019-1311-3

Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8 + T cell stemness and antitumor immunity

Autori: Dalton Hermans, Sanjivan Gautam, Juan C. García-Cañaveras, Daniel Gromer, Suman Mitra, Rosanne Spolski, Peng Li, Stephen Christensen, Rosa Nguyen, Jian-Xin Lin, Jangsuk Oh, Ning Du, Sharon Veenbergen, Jessica Fioravanti, Risa Ebina-Shibuya, Christopher Bleck, Leonard M. Neckers, Joshua D. Rabinowitz, Luca Gattinoni, Warren J. Leonard
Pubblicato in: Proceedings of the National Academy of Sciences, Numero 117/11, 2020, Pagina/e 6047-6055, ISSN 0027-8424
Editore: National Academy of Sciences
DOI: 10.1073/pnas.1920413117

SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia

Autori: Juan C. García-Cañaveras, Olga Lancho, Gregory S. Ducker, Jonathan M. Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D. Rabinowitz
Pubblicato in: Leukemia, 2020, ISSN 0887-6924
Editore: Nature Publishing Group
DOI: 10.1038/s41375-020-0845-6

Serine Catabolism Feeds NADH when Respiration Is Impaired

Autori: Lifeng Yang, Juan Carlos Garcia Canaveras, Zihong Chen, Lin Wang, Lingfan Liang, Cholsoon Jang, Johannes A. Mayr, Zhaoyue Zhang, Jonathan M. Ghergurovich, Le Zhan, Shilpy Joshi, Zhixian Hu, Melanie R. McReynolds, Xiaoyang Su, Eileen White, Raphael J. Morscher, Joshua D. Rabinowitz
Pubblicato in: Cell Metabolism, Numero 31/4, 2020, Pagina/e 809-821.e6, ISSN 1550-4131
Editore: Cell Press
DOI: 10.1016/j.cmet.2020.02.017

A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway

Autori: Jonathan M. Ghergurovich, Juan C. García-Cañaveras, Joshua Wang, Emily Schmidt, Zhaoyue Zhang, Tara TeSlaa, Harshel Patel, Li Chen, Emily C. Britt, Marta Piqueras-Nebot, Mari Carmen Gomez-Cabrera, Agustín Lahoz, Jing Fan, Ulf H. Beier, Hahn Kim, Joshua D. Rabinowitz
Pubblicato in: Nature Chemical Biology, Numero 16/7, 2020, Pagina/e 731-739, ISSN 1552-4450
Editore: Nature Publishing Group
DOI: 10.1038/s41589-020-0533-x