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Point-of-care device based on KETs for diagnosis of food allergies

Deliverables

Health Technology Assessment v1

This is the first version of the Health Technology Assessment. It defines the criteria that a device for detecting allergies in the PoC should meet to be cost-effective against current clinical practice.

Handbook on management

The Management handbook summarises all the required knowledge for the good management of the project (in terms of administrative forms, financial aspects, quality process…).

Initial dissemination plan

The dissemination plan encompasses the publications to be developed, the target groups to aim at and the platforms to use to make known the project and its results.

Updated dissemination report

This is an updated version of the dissemination plan.

Dissemination material (Project e-newsletters and brochures).

Dissemination materials such as newsletters and brochures.

Project public website

This is a the project website to make known the project. It will also be a tool to manage the internal documents related to the project among its partners.

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Publications

Molecular allergology and its impact in specific allergy diagnosis and therapy

Author(s): Domingo Barber, Araceli Diaz‐Perales, Maria M. Escribese, Jörg Kleine‐Tebbe, Paolo M. Matricardi, Markus Ollert, Alexandra F. Santos, Joaquin Sastre
Published in: Allergy, 2021, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.14969

New applications of advanced instrumental techniques for the characterization of food allergenic proteins

Author(s): Benedé S, Lozano-Ojalvo D, Cristobal S, Costa J, D'Auria E, Velickovic TC, Garrido-Arandia M, Karakaya S, Mafra I, Mazzucchelli G, Picariello G, Romero-Sahagun A, Villa C, Roncada P, Molina E.
Published in: Critical Reviews in Food Science and Nutrition, 2021, ISSN 1040-8398
Publisher: Taylor & Francis
DOI: 10.1080/10408398.2021.1931806

Real-life evaluation of molecular multiplex IgE test methods in the diagnosis of pollen associated food allergy

Author(s): Diem L., Neuherz B., Rohrhofer J., Koidl L., Asero R., Brockow K., Diaz-Perales A., Faber A., Gebhardt J., Torres MJ., Jensen-Jarolim E., Zehetmayer S., Untersmayr E.
Published in: Allergy, 2022, ISSN 1398-9995
Publisher: John Wiley and Sons
DOI: 10.1111/all.15329

NLRP3 priming due to skin damage precedes LTP allergic sensitization in a mouse model

Author(s): Diego Pazos-Castro, Zulema González-Klein, Alma Yuste-Montalvo, Guadalupe Hernández-Ramírez, Alejandro Romero-Sahagún, Vanesa Esteban, María Garrido-Arandia, Jaime Tome-Amat, Araceli Díaz-Perales
Published in: Scientific Reports, 2022, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-022-07421-y

The uncertainty and limit of detection in biosensors from immunoassays

Author(s): Jesús de Vicente, Álvaro Lavín, Miguel Holgado, María F Laguna, Rafael Casquel, Beatriz Santamaría, Sergio Quintero, Ana L Hernández, Yolanda Ramírez
Published in: Measurement Science and Technology, 31/4, 2020, Page(s) 044004, ISSN 0957-0233
Publisher: Institute of Physics and the Physical Society
DOI: 10.1088/1361-6501/ab49ec

New Label-Free Biosensing for the Evaluation of the AX-024 Inhibitor: Case Study for the Development of New Drugs in Autoimmune Diseases

Author(s): Yolanda Ramírez, María Fe Laguna and Miguel Holgado
Published in: Sensors, 2022, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s22031218

Are Physicochemical Properties Shaping the Allergenic Potency of Animal Allergens?

Author(s): Joana Costa, Caterina Villa, Kitty Verhoeckx, Tanja Cirkovic-Velickovic, Denise Schrama, Paola Roncada, Pedro M. Rodrigues, Cristian Piras, Laura Martín-Pedraza, Linda Monaci, Elena Molina, Gabriel Mazzucchelli, Isabel Mafra, Roberta Lupi, Daniel Lozano-Ojalvo, Colette Larré, Julia Klueber, Eva Gelencser, Cristina Bueno-Diaz, Araceli Diaz-Perales, Sara Benedé, Simona Lucia Bavaro, Annette Kuehn
Published in: Clinical Reviews in Allergy & Immunology, 2021, ISSN 1080-0549
Publisher: Humana Press, Inc.
DOI: 10.1007/s12016-020-08826-1

Developing an Optical Interferometric Detection Method based biosensor for detecting specific SARS-CoV-2 immunoglobulins in Serum and Saliva, and their corresponding ELISA correlation.

Author(s): A.M.M. Murillo; Jaime Tome-Amat; Yolanda Ramírez; María Garrido-Arandia; L.G. Valle; L.G. Valle; Guadalupe Hernandez-Ramirez; L. Tramarin; L. Tramarin; Pedro Herreros; Pedro Herreros; Beatriz Santamaría; Beatriz Santamaría; Araceli Díaz-Perales; Araceli Díaz-Perales; Miguel Holgado; Miguel Holgado
Published in: Sensors and Actuators. B, Chemical, 4, 2021, ISSN 0925-4005
Publisher: Elsevier BV
DOI: 10.1016/j.snb.2021.130394

ImmunoCAP ISAC in food allergy diagnosis: a systematic review of diagnostic test accuracy

Author(s): José-María Maesa, Agnieszka Dobrzynska, Elena Baños-Álvarez, Rebeca Isabel-Gómez, Juan-Antonio Blasco-Amaro
Published in: Clinical and experimental allergy, 2021, ISSN 1365-2222
Publisher: John Wiley & Sons Ltd
DOI: 10.1111/cea.13871

A new optical interferometric-based in vitro detection system for the specific IgE detection in serum of the main peach allergen

Author(s): R.L. Espinosa, M. Garrido-Arandia, A. Romero-Sahagun, P. Herreros, L. Tramarin, M.F. Laguna, A. Díaz-Perales, M. Holgado
Published in: Biosensors and Bioelectronics, 169, 2020, Page(s) 112641, ISSN 0956-5663
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bios.2020.112641

A Comparative Study of Human Saposins

Author(s): María Garrido-Arandia, Bruno Cuevas-Zuviría, Araceli Díaz-Perales, Luis Pacios
Published in: Molecules, 23/2, 2018, Page(s) 422, ISSN 1420-3049
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/molecules23020422

Energy Landscapes of Ligand Motion Inside the Tunnel-Like Cavity of Lipid Transfer Proteins: The Case of the Pru p 3 Allergen

Author(s): Bruno Cuevas-Zuviría, María Garrido-Arandia, Araceli Díaz-Perales, Luis Pacios
Published in: International Journal of Molecular Sciences, 20/6, 2019, Page(s) 1432, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms20061432

Interaction of Alt a 1 with SLC22A17 in the airway mucosa

Author(s): María Garrido‐Arandia, Jaime Tome‐Amat, Diego Pazos‐Castro, Vanesa Esteban, Maria M. Escribese, Guadalupe Hernández‐Ramírez, Alma Yuste‐Montalvo, Domingo Barber, Luis F. Pacios, Araceli Díaz‐Perales
Published in: Allergy, 2019, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.13877

Glycosylated nanostructures in sublingual immunotherapy induce long-lasting tolerance in LTP allergy mouse model

Author(s): Maria J. Rodriguez, Javier Ramos-Soriano, James R. Perkins, Ainhoa Mascaraque, Maria J. Torres, Francisca Gomez, Araceli Diaz-Perales, Javier Rojo, Cristobalina Mayorga
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-40114-7

On the Determination of Uncertainty and Limit of Detection in Label-Free Biosensors

Author(s): Álvaro Lavín, Jesús Vicente, Miguel Holgado, María Laguna, Rafael Casquel, Beatriz Santamaría, María Maigler, Ana Hernández, Yolanda Ramírez
Published in: Sensors, 18/7, 2018, Page(s) 2038, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s18072038

A Proof-of-Concept of Label-Free Biosensing System for Food Allergy Diagnostics in Biophotonic Sensing Cells: Performance Comparison with ImmunoCAP

Author(s): Rocio Espinosa, María Laguna, Fátima Fernández, Beatriz Santamaria, Francisco Sanza, Maria Maigler, Juan Álvarez-Millán, Víctor Canalejas-Tejero, Miguel Holgado
Published in: Sensors, 18/8, 2018, Page(s) 2686, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s18082686

A New Device Based on Interferometric Optical Detection Method for Label-Free Screening of C-Reactive Protein

Author(s): Maria V. Maigler, Miguel Holgado, Maria Fe Laguna, Francisco J. Sanza, Beatriz Santamaria, Alvaro Lavin, Rocio L. Espinosa
Published in: IEEE Transactions on Instrumentation and Measurement, 2018, Page(s) 1-7, ISSN 0018-9456
Publisher: Institute of Electrical and Electronics Engineers
DOI: 10.1109/tim.2018.2876073

Performance of basophil activation test and specific IgG4 as diagnostic tools in nonspecific lipid transfer protein allergy: Antwerp‐Barcelona comparison

Author(s): Ine I. Decuyper, Mariona Pascal, Athina L. Van Gasse, Christel Mertens, Araceli Díaz‐Perales, Giovanna Araujo, Maria Torradeflot, Josefina Rius, Sara Balsells, Rosa M. Muñoz‐Cano, Joan Bartra, Lynne Li, Vito Sabato, Margo M. Hagendorens, Chris H. Bridts, Luc S. De Clerck, Didier G. Ebo, Margaretha A. Faber
Published in: Allergy, 75/3, 2020, Page(s) 616-624, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.14040

A Point-of-Care Based on Label-Free Interferometric Optical Detection Method to Evaluate Interferon Gamma (IFN-γ): A Correlation with the ELISA Technique

Author(s): María Fe Laguna Heras, Yolanda Ramirez, Celia Fernández Martín, Rocío L. Espinosa, Alvaro Lavín, Miguel Holgado
Published in: Sensors, 20/17, 2020, Page(s) 4776, ISSN 1424-8220
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/s20174776

The diagnosis and management of allergic reactions in patients sensitized to non‐specific lipid transfer proteins

Author(s): Isabel J. Skypala, Joan Bartra, Didier G. Ebo, Margaretha Antje Faber, Montserrat Fernández‐Rivas, Francisca Gomez, Olga Luengo, Stephen J. Till, Riccardo Asero, Domingo Barber, Lorenzo Cecchi, Araceli Diaz Perales, Karin Hoffmann‐Sommergruber, Elide Anna Pastorello, Ines Swoboda, Anastasios. P. Konstantinopoulos, Ronald Ree, Enrico Scala
Published in: Allergy, 2021, ISSN 0105-4538
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/all.14797

Are Physicochemical Properties Shaping the Allergenic Potency of Plant Allergens?

Author(s): Joana Costa, Simona Lucia Bavaro, Sara Benedé, Araceli Diaz-Perales, Cristina Bueno-Diaz, Eva Gelencser, Julia Klueber, Colette Larré, Daniel Lozano-Ojalvo, Roberta Lupi, Isabel Mafra, Gabriel Mazzucchelli, Elena Molina, Linda Monaci, Laura Martín-Pedraza, Cristian Piras, Pedro M. Rodrigues, Paola Roncada, Denise Schrama, Tanja Cirkovic-Velickovic, Kitty Verhoeckx, Caterina Villa, Annette Kuehn
Published in: Clinical Reviews in Allergy & Immunology, 2021, ISSN 1080-0549
Publisher: Humana Press, Inc.
DOI: 10.1007/s12016-020-08810-9

The key to the allergenicity of lipid transfer protein (LTP) ligands: A structural characterization

Author(s): Zulema Gonzalez-Klein, Bruno Cuevas-Zuviria, Andrea Wangorsch, Guadalupe Hernandez-Ramirez, Diego Pazos-Castro, Carmen Oeo-Santos, Alejandro Romero-Sahagun, Luis F. Pacios, Jaime Tome-Amat, Stephan Scheurer, Araceli Diaz-Perales, María Garrido-Arandia
Published in: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1866/7, 2021, Page(s) 158928, ISSN 1388-1981
Publisher: Elsevier BV
DOI: 10.1016/j.bbalip.2021.158928

Optical Vapor Sensors Based on Periodic Resonant Nanopillar Structures

Author(s): Sergio Quintero, Rafael Casquel, Maria Fe Laguna, Miguel Holgado
Published in: ACS Omega, 5/40, 2020, Page(s) 25913-25918, ISSN 2470-1343
Publisher: ACS Omega
DOI: 10.1021/acsomega.0c03279