Competition for Space in Development and Diseases

Project Information

CoSpaDD

Grant agreement ID: 758457

DOI 10.3030/758457

Project closed

EC signature date 4 October 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 489 147,00

EU contribution € 1 489 147,00

Coordinated by

INSTITUT PASTEUR
France

Publications

Peer reviewed articles (10)

Toward a predictive understanding of epithelial cell death

Author(s): Tom Cumming, Romain Levayer
Published in: Seminars in Cell & Developmental Biology, 2023, ISSN 1096-3634
Publisher: Elsevier
DOI: 10.1016/j.semcdb.2023.06.008

LocalZProjector and DeProj: a toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.

Author(s): Sébastien Herbert; Léo Valon; Laure Mancini; Laure Mancini; Nicolas Dray; Paolo Caldarelli; Jerome Gros; Elric Esposito; Spencer L. Shorte; Laure Bally-Cuif; Romain Levayer; Nathalie Aulner; Jean-Yves Tinevez
Published in: BMC Biology, Issue 19, 2022, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-021-01037-w

Dying under pressure: cellular characterisation and in vivo functions of cell death induced by compaction

Author(s): Léo Valon, Romain Levayer
Published in: Biology of the Cell, Issue 111/3, 2019, Page(s) 51-66, ISSN 0248-4900
Publisher: Portland Press, Ltd.
DOI: 10.1111/boc.201800075

Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation

Author(s): Eduardo Moreno, Léo Valon, Florence Levillayer, Romain Levayer
Published in: Current Biology, Issue 29/1, 2019, Page(s) 23-34.e8, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.11.007

Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth

Author(s): Romain Levayer
Published in: Seminars in Cancer Biology, 2019, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2019.05.004

Multiple Influences of Mechanical Forces on Cell Competition

Author(s): Alexis Matamoro-Vidal, Romain Levayer
Published in: Current Biology, Issue 29/15, 2019, Page(s) R762-R774, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2019.06.030

DeXtrusion: automatic recognition of epithelial cell extrusion through machine learning in vivo

Author(s): Alexis Villars , Gaëlle Letort , Léo Valon, Romain Levayer
Published in: Development, Issue Volume 150, Issue 13, 2023, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.201747

Collective effects in epithelial cell death and cell extrusion.

Author(s): Alexis Villars; Romain Levayer
Published in: Current Opinion in Genetics and Development, Issue Voume 72, 2022, Page(s) 8-14, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2021.09.004

Microtubule disassembly by caspases is the rate-limiting step of cell extrusion

Author(s): Alexis Villars; Alexis Matamoro-Vidal; Florence Levillayer; Romain Levayer
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2021.10.15.464503

Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination.

Author(s): Léo Valon; Anđela Davidović; Florence Levillayer; Alexis Villars; Alexis Villars; Mathilde Chouly; Fabiana Cerqueira-Campos; Romain Levayer
Published in: Developmental Cell, Issue Volume 56, issue 12, 2021, Page(s) 1700-1711, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.05.006

Book chapters (1)

Chapter Five - Cell polarity and extrusion: How to polarize extrusion and extrude misspolarized cells?

Author(s): Ralitza Staneva, Romain Levayer
Published in: Current Topics in Developmental Biology, Issue Volume 154, 2023, Page(s) 131-167, ISBN 978-0-12-820158-9
Publisher: Elsevier
DOI: 10.1016/bs.ctdb.2023.02.010

Non-peer reviewed articles (1)

Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium

Author(s): Alexis Matamoro-Vidal; Tom Cumming; Anđela Davidović; Romain Levayer
Published in: BioRxiv, Issue 1, 2022, ISSN 2692-8205
Publisher: CSH
DOI: 10.1101/2022.03.11.484029

Other (1)

Robustness of epithelial sealing is an emerging property of local ERK feedbacks driven by cell elimination

Author(s): Léo Valon, Anđela Davidović, Florence Levillayer, Mathilde Chouly, Fabiana Cerqueira-Campos, Romain Levayer
Published in: Bioarchive, 2020
Publisher: Bioarchive
DOI: 10.1101/2020.03.17.994921