Deciphering the Molecular Foundations and Functional Competence of Alternative Human Naïve Pluripotent Stem Cells

Project Information

CELLNAIVETY

Grant agreement ID: 726497

DOI 10.3030/726497

Project closed

EC signature date 18 October 2017

Start date 1 November 2017

End date 31 October 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 2 000 000,00

EU contribution € 2 000 000,00

Coordinated by

WEIZMANN INSTITUTE OF SCIENCE
Israel

Publications

Peer reviewed articles (11)

Stage-specific requirement for Mettl3-dependent m6A mRNA methylation during haematopoietic stem cell differentiation

Author(s): Heather Lee, Suying Bao, Yingzhi Qian, Shay Geula, Juliana Leslie, Chaolin Zhang, Jacob H. Hanna, Lei Ding
Published in: Nature Cell Biology, Issue 21/6, 2019, Page(s) 700-709, ISSN 1465-7392
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-019-0318-1

Post-gastrulation synthetic embryos generated ex utero from mouse naive ESCs

Author(s): Shadi Tarazi , Alejandro Aguilera-Castrejon , Carine Joubran , Nadir Ghanem , Shahd Ashouokhi , Francesco Roncato , Emilie Wildschutz , Montaser Haddad , Bernardo Oldak, Elidet Gomez-Cesar, Nir Livnat, Sergey Viukov, Dmitry Lokshtanov, Segev Naveh-Tassa, Max Rose, Suhair Hanna, Calanit Raanan, Ori Brenner, Merav Kedmi, Hadas Keren-Shaul, Tsvee Lapidot, Itay Maza , Noa Novershtern , Jacob H Hanna
Published in: Cell, Issue 185(18), 2022, Page(s) 3290-3306, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2022.07.028

SUMOylation of linker histone H1 drives chromatin condensation and restriction of embryonic cell fate identity

Author(s): Daoud Sheban, Tom Shani , Roey Maor , Alejandro Aguilera-Castrejon , Nofar Mor , Bernardo Oldak , Merav D. Shmueli , Avital Eisenberg-Lerner , Jonathan Bayerl , Jakob Hebert , Sergey Viukov , Guoyun Chen , Assaf Kacen , Vladislav Krupalnik , Valeriya Chugaeva , Shadi Tarazi , Alejandra Rodríguez-delaRosa , Mirie Zerbib , Adi Ulman , Solaiman Masarwi , Meital Kupervaser , Yishai Levin , Efrat Shem
Published in: Molecular Cell, Issue 1 every 2 weeks, 2022, Page(s) 82(1): 106-122, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2021.11.011

Embryo model completes gastrulation to neurulation and organogenesis

Author(s): Gianluca Amadei, Charlotte E. Handford, Chengxiang Qiu, Joachim De Jonghe, Hannah Greenfeld, Martin Tran, Beth K. Martin, Dong-Yuan Chen, Alejandro Aguilera-Castrejon, Jacob H. Hanna, Michael B. Elowitz, Florian Hollfelder, Jay Shendure, David M. Glover & Magdalena Zernicka-Goetz
Published in: Nature, Issue 610, 2022, Page(s) 143-153, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41586-022-05246-3

OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

Author(s): Danna Sheinboim, Itay Maza, Iris Dror, Shivang Parikh, Vladislav Krupalnik, Rachel E. Bell, Asaf Zviran, Yusuke Suita, Ofir Hakim, Yael Mandel-Gutfreund, Mehdi Khaled, Jacob H. Hanna, Carmit Levy
Published in: Nature Communications, Issue 8/1, 2017, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-017-01122-1

β-Catenin safeguards the ground state of mousepluripotency by strengthening the robustness of the transcriptional apparatus

Author(s): Meng Zhang, Yiwei Lai, Vladislav Krupalnik, Pengcheng Guo, Xiangpeng Guo, Jianguo Zhou, Yan Xu, Zhijun Yu, Longqi Liu, Ao Jiang, Wenjuan Li, Mazid Md. Abdul, Gang Ma, Na Li, Xiuling Fu, Yuan Lv, Mengling Jiang, Muqddas Tariq, Shahzina Kanwal, Hao Liu, Xueting Xu, Hui Zhang, Yinghua Huang, Lulu Wang, Shuhan Chen, Isaac A. Babarinde, Zhiwei Luo, Dongye Wang, Tiantian Zhou, Carl Ward, Minghui He, Dav
Published in: Science Advances, Issue 6/29, 2020, Page(s) eaba1593, ISSN 2375-2548
Publisher: Science - AAAS
DOI: 10.1126/sciadv.aba1593

Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Author(s): Nofar Mor, Yoach Rais, Daoud Sheban, Shani Peles, Alejandro Aguilera-Castrejon, Asaf Zviran, Dalia Elinger, Sergey Viukov, Shay Geula, Vladislav Krupalnik, Mirie Zerbib, Elad Chomsky, Lior Lasman, Tom Shani, Jonathan Bayerl, Ohad Gafni, Suhair Hanna, Jason D. Buenrostro, Tzachi Hagai, Hagit Masika, Gintautas Vainorius, Yehudit Bergman, William J. Greenleaf, Miguel A. Esteban, Ulrich Elling, Yishai
Published in: Cell Stem Cell, Issue 23/3, 2018, Page(s) 412-425.e10, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.07.004

Deterministic Somatic Cell Reprogramming Involves Continuous Transcriptional Changes Governed by Myc and Epigenetic-Driven Modules

Author(s): Asaf Zviran, Nofar Mor, Yoach Rais, Hila Gingold, Shani Peles, Elad Chomsky, Sergey Viukov, Jason D. Buenrostro, Roberta Scognamiglio, Leehee Weinberger, Yair S. Manor, Vladislav Krupalnik, Mirie Zerbib, Hadas Hezroni, Diego Adhemar Jaitin, David Larastiaso, Shlomit Gilad, Sima Benjamin, Ohad Gafni, Awni Mousa, Muneef Ayyash, Daoud Sheban, Jonathan Bayerl, Alejandro Aguilera-Castrejon, Rada Massar
Published in: Cell Stem Cell, Issue 24/2, 2019, Page(s) 328-341.e9, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2018.11.014

Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells

Author(s): Sergey Viukov , Tom Shani , Jonathan Bayerl , Alejandro Aguilera-Castrejon , Bernardo Oldak , Daoud Sheban , Shadi Tarazi , Yonatan Stelzer , Jacob H Hanna, Noa Novershtern
Published in: Stem Cell Reports, Issue 17(11), 2022, Page(s) 2484-2500, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2022.09.008

Context-dependent functional compensation between Ythdf m6A reader proteins

Author(s): Lior Lasman, Vladislav Krupalnik, Sergey Viukov, Nofar Mor, Alejandro Aguilera-Castrejon, Dan Schneir, Jonathan Bayerl, Orel Mizrahi, Shani Peles, Shadi Tawil, Shashank Sathe, Aharon Nachshon, Tom Shani, Mirie Zerbib, Itay Kilimnik, Stefan Aigner, Archana Shankar, Jasmine R. Mueller, Schraga Schwartz, Noam Stern-Ginossar, Gene W. Yeo, Shay Geula, Noa Novershtern, and Jacob H. Hanna
Published in: Genes and Development, Issue 34, 2020, Page(s) 1373-1391, ISSN 0890-9369
Publisher: Cold Spring Harbor Laboratory Press
DOI: 10.1101/gad.340695.120

Ex utero mouse embryogenesis from pre-gastrulation to late organogenesis

Author(s): Alejandro Aguilera-Castrejon, Bernardo Oldak, Tom Shani, Nadir Ghanem, Chen Itzkovich, Sharon Slomovich, Shadi Tarazi, Jonathan Bayerl, Valeriya Chugaeva, Muneef Ayyash, Shahd Ashouokhi, Daoud Sheban, Nir Livnat, Lior Lasman, Sergey Viukov, Mirie Zerbib, Yoseph Addadi, Yoach Rais, Saifeng Cheng, Yonatan Stelzer, Hadas Keren-Shaul, Raanan Shlomo, Rada Massarwa, Noa Novershtern, Itay Maza, Jacob H.
Published in: Nature, Issue weekly, 2021, Page(s) 593(7857):119-124, ISSN 1476-4687
Publisher: Nature
DOI: 10.1038/s41586-021-03416-3