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Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine

Deliverables

Microfluidic device for iPSC differentiation into Cardiomyocyte

Fabrication of microfluidic device dedicated to the iPSC differentiation into cardiomyocyte. The microfluidic chip will exploit a biochemical procedure for iPSC differentiation. This first prototype will be fabricated in PDMS.

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Publications

Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling

Author(s): María Virumbrales-Muñoz, Jose M. Ayuso, Alodia Lacueva, Teodora Randelovic, Megan K. Livingston, David J. Beebe, Sara Oliván, Desirée Pereboom, Manuel Doblare, Luis Fernández, Ignacio Ochoa
Published in: Scientific Reports, 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-42529-8

Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

Author(s): Kalina Andrysiak; Jacek Stępniewski; Jozef Dulak
Published in: Pflugers Archiv - European Journal of Physiology, 3, 2021, ISSN 0031-6768
Publisher: Springer Verlag
DOI: 10.1007/s00424-021-02536-z

Heart-on-a-chip

Author(s): Pierre Gaudriault, Dario Fassini, Antoni Homs-Corbera
Published in: Organ-on-a-chip, 2020, Page(s) 255-293, ISBN 9780128172025
Publisher: Elsevier
DOI: 10.1016/b978-0-12-817202-5.00008-5