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Heart On chip based on induced pluripotent Stem cell Technology for personalized Medicine

Deliverables

Communication and public engagement plan No. 1
Report on workshops/Networking activities

Report on Workshop List of attendees work programme workshop results summary audiovisual material and slides Networking activities Events future potential collaborative project

Communication and public engagement plan No. 2
Microfluidic device for iPSC differentiation into Cardiomyocyte

Fabrication of microfluidic device dedicated to the iPSC differentiation into cardiomyocyte. The microfluidic chip will exploit a biochemical procedure for iPSC differentiation. This first prototype will be fabricated in PDMS.

Publications

Surface modifications of COP-based microfluidic devices for improved immobilisation of hydrogel proteins: long-term 3D culture with contractile cell types and ischaemia model

Author(s): Sandra González-Lana; Teodora Randelovic; Jesús Ciriza; María López-Valdeolivas; Rosa Monge; Carlos Sánchez-Somolinos; Ignacio Ochoa
Published in: Lab on a chip, Issue 8, 2023, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d3lc00075c

Enabling cell recovery from 3D cell culture microfluidic devices for tumour microenvironment biomarker profiling

Author(s): María Virumbrales-Muñoz, Jose M. Ayuso, Alodia Lacueva, Teodora Randelovic, Megan K. Livingston, David J. Beebe, Sara Oliván, Desirée Pereboom, Manuel Doblare, Luis Fernández, Ignacio Ochoa
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-42529-8

Towards novel biomimetic in vitro models of the blood-brain barrier for drug permeability evaluation

Author(s): Mármol, Inés; Abizanda-Campo, Sara; Ayuso, José M.; Ochoa, Ignacio; Oliván, Sara
Published in: Bioengineering, Issue 10, 2023, ISSN 2306-5354
Publisher: mdpi
DOI: 10.3390/bioengineering10050572

Current approaches for the recreation of cardiac ischaemic environment in vitro

Author(s): Laura Paz-Artigas, Pilar Montero-Calle, Olalla Iglesias-García, Manuel M. Mazo, Ignacio Ochoa , Jesús Ciriza
Published in: International Journal of Pharmaceutics, 2023, ISSN 0378-5173
Publisher: Elsevier BV
DOI: 10.1016/j.ijpharm.2023.122589

Gene therapy. The legacy of Wacław Szybalski.

Author(s): Jozef Dulak
Published in: Acta Biochimica Polonica, Issue 5, 2020, ISSN 1734-154X
Publisher: Polskie Towarzystwo Biochemiczne
DOI: 10.18388/abp.2020_5805

Adaptation of cardiomyogenesis to the generation and maturation of cardiomyocytes from human pluripotent stem cells

Author(s): Alicja Martyniak, Mateusz Jeż, Józef Dulak, Jacek Stępniewski
Published in: IUBMB Life, 2023, ISSN 1521-6551
Publisher: John Wiley & Sons
DOI: 10.1002/iub.2685

Human-induced pluripotent stem cell-derived cardiomyocytes, 3D cardiac structures, and heart-on-a-chip as tools for drug research

Author(s): Kalina Andrysiak; Jacek Stępniewski; Jozef Dulak
Published in: Pflugers Archiv - European Journal of Physiology, Issue 3, 2021, ISSN 0031-6768
Publisher: Springer Verlag
DOI: 10.1007/s00424-021-02536-z

Heart-on-a-chip

Author(s): Pierre Gaudriault, Dario Fassini, Antoni Homs-Corbera
Published in: Organ-on-a-chip, 2020, Page(s) 255-293, ISBN 9780128172025
Publisher: Elsevier
DOI: 10.1016/b978-0-12-817202-5.00008-5

Application of human induced pluripotent stem cells and CRISPR/Cas9 gene editing technology for investigation of molecular background of Duchenne muscular dystrophy-related cardiomyopathy

Author(s): Kalina Andrysiak
Published in: 2022
Publisher: Repozytorium Uniwersytetu Jagiellońskiego

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