Objective
MyPeBS addresses the crucial and timely question of the future of breast cancer screening in Europe. Indeed current standard mammographic screening, with entry stratified by age alone, has recently been largely questioned. Despite a demonstrated mean 20% reduction in breast cancer-specific mortality, together with reduction of late-stage disease in women older than 50, it is associated with potential harms including false positive recalls and over-diagnosis.
Individual breast cancer risk estimation, through models including clinical variables, mammographic breast density and more than 100 genetic polymorphisms, now has substantial clinical and scientific bases. Personalized screening strategies, based on individual risk levels, could potentially improve the individual benefit/harms ratio of screening (earlier cancer detection and less intensive treatments in high risk women, less false positives and over-diagnoses in low risk ones), and increase the cost-efficacy for health insurances.
MyPEBS will conduct an international randomized phase III trial to validate this hypothesis. It will primarily assess the ability of an individual risk-based screening strategy to be non-inferior, and possibly superior, to the standard of care screening, in reducing the cumulative incidence of stage II+ breast cancers. The trial, conducted in 5 countries (France, Italy, UK, Belgium and Israel) will include 85000 European women aged 40-70, all followed for 4 years. MyPEBS will also evaluate if an individual risk-based screening strategy, compared with the standard, reduces screening-related harms (unnecessary biopsies, overdiagnoses) in low-risk women, is overall at least as cost-effective as well as more accepted by women resulting in a larger screening coverage. After analyses of all components, the final objective of MyPEBS is to deliver recommendations for the best future breast cancer screening strategy in Europe.
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Programme(s)
Funding Scheme
RIA - Research and Innovation actionCoordinator
75013 Paris
France
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Participants (31)
Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
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21079 Dijon
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94805 Villejuif
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M13 9PL Manchester
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CB2 1TN Cambridge
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3015 GD Rotterdam
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E1 4NS London
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94800 Villejuif
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
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93430 Villetaneuse
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42100 Reggio Emilia
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1070 Anderlecht
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LE11 3TU Loughborough
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94607 OAKLAND CA
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10126 Torino
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94415 SAINT MAURICE
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EC1R 0LL London
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10121 Torino
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
1030 Bruxelles / Brussel
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93100 Montreuil
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69710 Tel Aviv
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47014 Meldola
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Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.
48121 Ravenna
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50139 Firenze
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69622 Villeurbanne Cedex
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94800 Villejuif
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7000 Mons
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
75010 Paris
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
75015 PARIS 15
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NG7 2RD Nottingham
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1140 Evere
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08003 Barcelona
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13284 Marseille
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