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CORDIS

Regulatory Science Framework for Nano(bio)material-based Medical Products and Devices

Livrables

"Project website, and project ""brand"""

DSS delivery, validation, performance testing and training of users

The final softwareimplemented DSS including user guide will be tested on the selected case studies on 3 representatives nanomaterials Lipidots PACA and gold nanoparticles The accompanying documentation will include data from the DSS application to the study cases At least 20 prospective DSS users will be invited to a workshop for targeted training selected in interaction with WP6

REFINE user communities

Two communities of active contributors each of about 12 members strong will be established They will cocreate the DSS in particular the interface and options to add users preferences and will support WP 25 by offering methodsprocedures for the WP2 inventory andor participate in interlaboratory comparisons

First beta version DSS

We will arrange a workshop where approximately 20-25 stakeholders (regulators, industry, academia) are invited to inspect and interact with the early version of the DSS, including example data sets for input. This will give valuable feedback on adjustments of the DSS to users' needs and wishes.

Knowledge-HUB (K-HUB: Social media strategy implementation, explicit knowledge sharing repository)

This online platform should provide access to all non-confidential REFINE results. The platform should be searchable and allow filtering, contributions and -if deemed useful- opportunities to engage in online discussions. We will make use of the glossary of terminology to appeal to various stakeholder communities.

REFINE final KEC

An international event with participation form all relevant stakeholder communities nonEU world regions and policy makersresearch funding programmes

DSS stakeholder interaction workshop

We will arrange a workshop where approximately 20-25 stakeholders (regulators, industry, academia) are invited to inspect and interact with the early version of the DSS, including example data sets for input. This will give valuable feedback on adjustments of the DSS to users' needs and wishes.

Progress report on the use of the whitepaper in community discussions, in particular the Knowldege Exchange Conferences, and the feed in to various knowledge bases used for regulatory purposes

We will review whether the whitepaper works as kernel for a sustained dialoge of regulators scientists and developers

Two workshops with strong participation from regulators

Two workshops will be organised with at least 15 external participants each, from regulatory bodies and expert-level scientific committees related to regulatory bodies, plus additional high-level participants from research and development.

Reflection Document

A reflection document will present the outline of the methodology to design intelligent testing strategies, considerations regarding populating the repository and ranking methods according to product and measurand, current observations on CQAs, as well as approaches and structures intended for the DSS. This document will serve both as an internal orientation and as a foundation for interaction with external stakeholders as it will feed into the whitepaper-drafting in WP1.

Guidance Manual for stakeholders

The Guidance Manual will include the methodology to design intelligent testing strategies the inventory of testing methods and procedures and the CQA recommendations The development of the DSS will also be described The format will be targeted towards all relevant stakeholders

Report outlining the transferability of the in silico approach together with the linked in vitro assays

The report outlines the outcome of the test for transferability of the in silico approach together with the linked in vitro assays which is based on an interlaboratory comparison The report also includes the comprehesive statistical analysis of all the results together with the collection of the SOPs of the in silico approach and of all standardised in vitro assays used in this context

First draft of whitepaper

The draft whitepaper will propose a catalogue of information requirements and needs for harmonisation (e.g. to address borderline products that fall under different legislature in different world regions). It will propose a gap analysis, where scientific state of the art and regulatory practice seem out of step (e.g. present a list of major adversities of administered NBMs described in the scientific literature, that are hard to predict by current standard testing methods). Thirdly the document will propose a heuristic how to assimilate new evidence in reliable and efficient way into regulatory strategies (e.g. which testing methods would deliver information that supports the modeling of an NMB-specific Adverse Outcome Pathway, for example for CARPA ).

Report on inventory of testing methods and -procedures

The statusquo of the repository with integrated ranking Task 22 will be reported in this deliverable This deliverable marks the start of consolidating the inventory within the methodology for intelligent testing architectures at the same time the deliverables serves as check whether we inspired a critial contribution from stakeholders information about testing methods performance and access to protocols that could be used in the inventory

Report on in vitro characterization of nanoparticle distribution

Report on the quantitative evaluation of key variables such as apparent permeability through various barriers systems, or uptake kinetics in key cell populations

List of requirements for any method re eligibility for regulatory acceptance/ standardisation

The report summarizes the outcome of the interlaboratory comparison which tests the transferability of the involved methods The report also includes the comprehesive statistical analysis of all the results together with the collection of the SOPs

Publications

Delivery of oligonucleotide-based therapeutics: challenges and opportunities.

Auteurs: Suzan M. Hammond; Annemieke Aartsma-Rus; Sandra Alves; Sven Even F. Borgos; Ronald A.M. Buijsen; Rob W.J. Collin; Giuseppina Covello; Giuseppina Covello; Michela A. Denti; Lourdes R. Desviat; Lucia Echevarria; Camilla Foged; Gisela Gaina; Alejandro Garanto; Aurélie Goyenvalle; Magdalena Guzowska; Irina Holodnuka; David R. Jones; Sabine Krause; Taavi Lehto; Taavi Lehto; Marisol Montolio; Willeke M
Publié dans: Hammond , S M , Aartsma-Rus , A , Alves , S , Borgos , S E , Buijsen , R A M , Collin , R W J , Covello , G , Denti , M A , Desviat , L R , Echevarría , L , Foged , C , Gaina , G , Garanto , A , Goyenvalle , A T , Guzowska , M , Holodnuka , I , Jones , D R , Krause , S , Lehto , T , Montolio , M , Van Roon-Mom , W & Arechavala-Gomeza , V 2021 , ' Delivery of oligonucleotide-based therapeutics : c, Numéro 8, 2021, ISSN 1757-4676
Éditeur: John Wiley & Sons Ltd.
DOI: 10.15252/emmm.202013243

Pharmacokinetic modelling to estimate intracellular favipiravir ribofuranosyl-5'-triphosphate exposure to support posology for SARS-CoV-2

Auteurs: Henry Pertinez; Rajith K. R. Rajoli; Saye Khoo; Andrew Owen
Publié dans: Journal of Antimicrobial Chemotherapy, Numéro 1, 2021, ISSN 0305-7453
Éditeur: Oxford University Press
DOI: 10.1101/2021.01.03.21249159

Preclinical Development of Orally Inhaled Drugs (OIDs)-Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?

Auteurs: Dania Movia; Adriele Prina-Mello
Publié dans: Animals : an Open Access Journal from MDPI, Numéro 1, 2020, ISSN 2076-2615
Éditeur: MDPI AG
DOI: 10.3390/ani10081259

Label-Free Digital Holographic Microscopy for In Vitro Cytotoxic Effect Quantification of Organic Nanoparticles

Auteurs: Kai Moritz Eder, Anne Marzi, Álvaro Barroso, Steffi Ketelhut, Björn Kemper, and Jürgen Schnekenburger
Publié dans: Cells, 2022, ISSN 2073-4409
Éditeur: MDPI
DOI: 10.3390/cells11040644

Dose Prediction for Repurposing Nitazoxanide in SARS-CoV-2 Treatment or Chemoprophylaxis

Auteurs: Rajith K. R. Rajoli; Henry Pertinez; Usman Arshad; Helen Box; Lee Tatham; Paul Curley; Megan Neary; Joanne Sharp; Neill J. Liptrott; Anthony Valentijn; Christopher David; Steve P. Rannard; Ghaith Aljayyoussi; Shaun H. Pennington; Andrew Hill; Marta Boffito; Stephen A. Ward; Saye Khoo; Patrick G. Bray; Paul M. O'Neill; W. David Hong; Giancarlo A. Biagini; Andrew Owen
Publié dans: medRxiv, Numéro 9, 2021, ISSN 0306-5251
Éditeur: Blackwell Publishing Inc.
DOI: 10.22541/au.158938595.50403411

A Substrate-Mimicking Basement Membrane Drives the Organization of Human Mesenchymal Stromal Cells and Endothelial Cells Into Perivascular Niche-Like Structures

Auteurs: Perugini V., Santin M.
Publié dans: Frontiers in Cell and Developmental Biology, 2021, ISSN 2296-634X
Éditeur: Frontiers Media S.A.
DOI: 10.3389/fcell.2021.701842

Interlaboratory Evaluation of Digital Holographic Microscopy-based Assay for label-free Medical Nanoparticle in vitro Cytotoxicity Testing

Auteurs: Anne Marzi, Kai Moritz Eder, Álvaro Barroso, Ane Marit Wågbø, Torkild Visnes, Geir Klinkenberg, Björn Kemper, Jürgen Schnekenburger
Publié dans: Drug Delivery and Translational Research, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,

A physiologically based pharmacokinetic model to predict Pegylated LiposomalDoxorubicin disposition in rats and human

Auteurs: Maiara Camotti Montanha, Alice Howarth, Doaa Ahmed Mohamed, Estelle Loier, Lauren Main, Matthias Rösslein, Christiaan Delmaar, Adriele Prina-Mello, Marco Siccardi
Publié dans: Drug Delivery and Translational Research, Numéro 2190393X, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01175-w

Endotoxin contamination of engineered nanomaterials: Overcoming the hurdles associated with endotoxin testing

Auteurs: Hannon G., Prina-Mello A.
Publié dans: Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, 2021, ISSN 1939-5116
Éditeur: John Wiley and Sons Inc
DOI: 10.1002/wnan.1738

A comparative biodistribution study of polymeric and lipid-based nanoparticles

Auteurs: Andreas K.O. Åslund, Rob J. Vancebriel, Fanny Caputo, Wim H. de Jong, Christiaan Delmaar, Astrid Hyldbakk, Emilie Rustique, Ruth Schmid, Sofie Snipstad, Isabelle Texier, Kai Vernstad, Sven Even F. Borgos
Publié dans: Drug Delivery and Translational Research, Numéro 2190393X, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01159-w

Docetaxel gold complex nanoflowers: A chemo-biological evaluation for their use as nanotherapeutics.

Auteurs: Maroua Ben Haddada; Dania Movia; Adriele Prina-Mello; Jolanda Spadavecchia
Publié dans: Colloids and Surfaces B: Biointerfaces, Numéro 6, 2020, ISSN 0927-7765
Éditeur: Elsevier BV
DOI: 10.1016/j.colsurfb.2020.111172

Nano-enabled medicinal products: Time for an international advanced community?

Auteurs: Gioria S., Caputo F., Mehn D.
Publié dans: Nanomedicine, 2019, ISSN 1743-5889
Éditeur: Future Medicine Ltd.
DOI: 10.2217/nnm-2019-0173

An Open Label, Adaptive, Phase 1 Trial of High-Dose Oral Nitazoxanide in Healthy Volunteers: An Antiviral Candidate for SARS-CoV-2

Auteurs: Walker L.E., FitzGerald R., Saunders G., Lyon R., Fisher M., Martin K., Eberhart I., Woods C., Ewings S., Hale C., Rajoli R.K.R., Else L., Dilly-Penchala S., Amara A., Lalloo D.G., Jacobs M., Pertinez H., Hatchard P., Waugh R., Lawrence M., Johnson L., Fines K., Reynolds H., Rowland T., Crook R., Okenyi E., Byrne K., Mozgunov P., Jaki T., Khoo S., Owen A., Griffiths G., Fletcher T.E., the AGILE pl
Publié dans: Clinical Pharmacology and Therapeutics, 2021, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.2463

Physiologically-based pharmacokinetic modelling of intravenously administrered nanoformulated substances

Auteurs: Jordi Minnema, Sven Even F. Borgos, Neill Liptrott, Rob Vandebriel, Christiaan Delmaar
Publié dans: Drug Delivery and Translational Research, Numéro 2190393X, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01145-2

Subcellular detection of PEBCA particles in macrophages: combining darkfield microscopy, confocal Raman microscopy, and ToF-SIMS analysis

Auteurs: Antje Vennemann, Daniel Breitenstein, Elke Tallarek, Yrr Mørch, Ruth Schmid, Martin Wiemann
Publié dans: Drug Delivery and Translational Research, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01128-3

Pre-clinical 2D and 3D toxicity response to a panel of nanomaterials; Comparative assessment of NBM-induced liver toxicity

Auteurs: Melissa Anne Tutty, Adriele Prina-Mello, Gabriele Vella
Publié dans: Drug Delivery and Translational Research, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.21203/rs.3.rs-1277778/v1

Immunotoxicity Considerations for Next Generation Cancer Nanomedicines

Auteurs: Hannon, Gary; Lysaght, Joanne; Liptrott, Neill J.; Prina‐Mello, Adriele
Publié dans: Advanced Science, Vol 6, Iss 19, Pp n/a-n/a (2019), Numéro 4, 2019, ISSN 2198-3844
Éditeur: John Wiley and Sons Inc.
DOI: 10.1002/advs.201900133

Towards more predictive, physiological and animal-free in vitro models: Advances in cell and tissue culture 2020 conference proceedings

Auteurs: Singh B., Abdelgawad M.E., Ali Z., Bailey J., Budyn E., Civita P., Clift M.J.D., Connelly J.T., Constant S., Hittinger M., Kandarova H., Kearns V.R., Kiuru T., Kostrzewski T., Kress S., Durban V.M., Lehr C.-M., McMillan H., Metz J.K., Monteban V., Movia D., Neto C., Owen C., Paasonen L., Palmer K.A., Pilkington G.J., Pilkington K., Prina-Mello A., Roper C., Sheard J., Smith S., Turner J.E., Roy I.
Publié dans: ATLA Alternatives to Laboratory Animals, 2021, ISSN 0261-1929
Éditeur: Fund for the Replacement of Animals in Medical Experiments
DOI: 10.1177/02611929211025006

Bridging communities in the field of nanomedicine.

Auteurs: Halamoda-Kenzaoui, Blanka; Baconnier, Simon; Bastogne, Thierry; Bazile, Didier; Boisseau, Patrick; Borchard, Gerrit; Borgos, Sven Even; Calzolai, Luigi; Cederbrant, Karin; Di Felice, Gabriella; Di Francesco, Tiziana; Dobrovolskaia, Marina A.; Gaspar, Rogério; Gracia, Belén; Hackley, Vincent A.; Leyens, Lada; Liptrott, Neill; Park, Margriet; Patri, Anil; Roebben, Gert; Roesslein, Matthias; Thürm
Publié dans: Regulatory Toxicology and Pharmacology, Numéro 3, 2019, ISSN 0273-2300
Éditeur: Academic Press
DOI: 10.1016/j.yrtph.2019.04.011

Launching stakeholder discussions on identified regulatory needs for nanotechnology-enabled health products

Auteurs: B. HALAMODA-KENZAOUI, H. BOX, M. VAN ELK, S. GAITAN, R. GEERTSMA, E. GAINZA LAFUENTE, A. OWEN, A. DEL POZO, M. ROESSLEIN, S. BREMER- HOFFMANN
Publié dans: Precision Nanomedicine, 2020, ISSN 2639-9431
Éditeur: Andover House
DOI: 10.33218/001c.13521

Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range

Auteurs: Caputo F., Vogel R., Savage J., Vella G., Law A., Della Camera G., Hannon G., Peacock B., Mehn D., Ponti J., Geiss O., Aubert D., Prina-Mello A., Calzolai L.
Publié dans: Journal of Colloid and Interface Science, 2021, ISSN 0021-9797
Éditeur: Academic Press
DOI: 10.1016/j.jcis.2020.12.039

A comparative in vitro study of the effect of biospecific integrin recognition processes and substrate nanostructure on stem cell 3D spheroid formation

Auteurs: Valeria Perugini; Matteo Santin
Publié dans: Journal of Materials Science. Materials in Medicine, Numéro 3, 2020, ISSN 1573-4838
Éditeur: Springer Nature
DOI: 10.1007/s10856-020-06373-x

Melissa Anne Tutty, Dania Movia, Adriele Prina-Mello

Auteurs: Three-dimensional (3D) liver cell models - A tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials
Publié dans: Drug Delivery and Translational Research, Numéro 2190393X, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01147-0

Development of scaffold-free vascularized pancreatic beta-islets in vitro models by the anchoring of cell lines to a bioligand-functionalized gelatine substrate

Auteurs: Valeria Perugini, Samuel M. Flaherty, Matteo Santin
Publié dans: Journal of Materials Science: Materials in Medicine, 2022, Page(s) 33:37, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s10856-022-06658-3

Toward Consensus on Correct Interpretation of Protein Binding in Plasma and Other Biological Matrices for COVID-19 Therapeutic Development

Auteurs: Boffito M., Back D.J., Flexner C., Sjö P., Blaschke T.F., Horby P.W., Cattaneo D., Acosta E.P., Anderson P., Owen A.
Publié dans: Clinical Pharmacology and Therapeutics, 2021, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.2099

Standardization of an in vitro Assay Matrix to assess Cytotoxicity of Organic Nanocarriers: an Interlaboratory Comparison

Auteurs: Kai Moritz Eder, Anne Marzi, Ane Marit Wågbø, Jolanda P. Vermeulen, Liset J.J. de la Fonteyne-Blankestijn, Matthias Rösslein, Rainer Ossig, Geir Klinkenberg, Rob J. Vandebriel, Jürgen Schnekenburger
Publié dans: Drug Delivery and Translational Research, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,

Biophysical Characterization of Viral and Lipid-Based Vectors for Vaccines and Therapeutics with Light Scattering and Calorimetric Techniques

Auteurs: Markova N., Cairns S., Jankevics-Jones H., Kaszuba M., Caputo F., Parot J.
Publié dans: Vaccines, 2021, ISSN 2076-393X
Éditeur: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/vaccines10010049

Shutting the gate before the horse has bolted: is it time for a conversation about SARS-CoV-2 and antiviral drug resistance?

Auteurs: Julian A. Hiscox; Julian A. Hiscox; Saye Khoo; James P. Stewart; Andrew Owen
Publié dans: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, Numéro 2, 2021, ISSN 0305-7453
Éditeur: Oxford University Press
DOI: 10.1093/jac/dkab189

Improved multidetector asymmetrical-flow field-flow fractionation method for particle sizing and concentration measurements of lipid-based nanocarriers for RNA delivery

Auteurs: Mildner R., Hak S., Parot J., Hyldbakk A., Borgos S.E., Some D., Johann C., Caputo F.
Publié dans: European Journal of Pharmaceutics and Biopharmaceutics, 2021, ISSN 0939-6411
Éditeur: Elsevier BV
DOI: 10.1016/j.ejpb.2021.03.004

Decision support system for preclinical assessment of nano/biomaterials used in the medical sector: the REFINE DSS

Auteurs: Alex Zabeo, Fabio Rosada, Lisa Pizzol, Fanny Caputo, Sven Even Borgos, Jeremie Parot, Robert E Geertsma, Joost Jacob Pouw, Rob J Vandebriel, Oihane Ibarrola Moreno, Danail Hristozov
Publié dans: Drug Delivery and Translational Research, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.21203/rs.3.rs-1246960/v1

Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?

Auteurs: Robert Vogel; John Savage; Julien Muzard; Giacomo Della Camera; Gabriele Vella; Alice Law; Marianne Marchioni; Dora Mehn; Otmar Geiss; Ben Peacock; Dimitri Aubert; Luigi Calzolai; Fanny Caputo; Adriele Prina-Mello
Publié dans: Journal of Extracellular Vesicles, Vol 10, Iss 3, Pp n/a-n/a (2021), Numéro 8, 2021, ISSN 2001-3078
Éditeur: John Wiley and Sons Inc
DOI: 10.1002/jev2.12052

Prioritization of Anti-SARS-Cov-2 Drug Repurposing Opportunities Based on Plasma and Target Site Concentrations Derived from their Established Human Pharmacokinetics

Auteurs: Arshad U., Pertinez H., Box H., Tatham L., Rajoli R.K.R., Curley P., Neary M., Sharp J., Liptrott N.J., Valentijn A., David C., Rannard S.P., O’Neill P.M., Aljayyoussi G., Pennington S.H., Ward S.A., Hill A., Back D.J., Khoo S.H., Bray P.G., Biagini G.A., Owen A.
Publié dans: Clinical Pharmacology and Therapeutics, 2020, ISSN 0009-9236
Éditeur: Nature Publishing Group
DOI: 10.1002/cpt.1909

Methodological needs in the quality and safety characterisation of nanotechnology-based health products: Priorities for method development and standardisation

Auteurs: B. Halamoda-Kenzaoui, R.J. Vandebriel, A. Howarth, M. Siccardi, C.A.W. David, N.J. Liptrott, M. Santin, S.E. Borgos, S. Bremer-Hoffmann, F. Caputo
Publié dans: Journal of Controlled Release, Numéro 336, 2021, Page(s) 192-206, ISSN 0168-3659
Éditeur: Elsevier BV
DOI: 10.1016/j.jconrel.2021.06.016

A Multi-step In Vitro Hemocompatibility Testing Protocol Recapitulation the Foregn Body Reaction to Nanocarriers

Auteurs: Valeria Perugini, Ruth Schmid, Yrr Mørch, Isabelle Texier, Martin Brodde, Matteo Santin
Publié dans: Drug Delivery and Translational Research, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,
DOI: 10.1007/s13346-022-01141-6

Reflection Document

Auteurs: Lead beneficiary: SINTEF
Publié dans: 2018
Éditeur: REFINE Project

DSS STAKEHOLDER INTERACTION WORKSHOP

Auteurs: Lead beneficiary: GreenDecision
Publié dans: 2020
Éditeur: REFINE Project

Two workshops with strong participation from regulators

Auteurs: Lead beneficiary: Joint Research Center
Publié dans: 2019
Éditeur: REFINE Project

First draft of White Paper

Auteurs: Lead beneficiary: Joint Research Center
Publié dans: 2018
Éditeur: REFINE Project

REPORT ON IN VITRO CHARACTERIZATION OF NANOPARTICLEDISTRIBUTION

Auteurs: Lead beneficiary: University of Liverpool
Publié dans: 2019
Éditeur: REFINE Project

Anticipation of regulatory needs for nanotechnology-enabled health products

Auteurs: B. HALAMODA-KENZAOUI, H. BOX, M. VAN ELK, S. GAITAN, R. GEERTSMA, E. GAINZA LAFUENTE, A. OWEN, A. DEL POZO, M. ROESSLEIN, S. BREMER- HOFFMANN
Publié dans: 2019, ISSN 1831-9424
Éditeur: Publications Office of the European Union
DOI: 10.2760/596822

Organoid Formation Driven by Synthetic Biomaterials Mimicking the Basement Membrane

Auteurs: Valeria Perugini, Matteo Santin
Publié dans: Chinese-European Societies for Biomaterials Conference, 2019
Éditeur: Chinese Society for Biomaterials (CSBM) and European Society for Biomaterials (ESB)

Medical nanoparticle impact on macrophage temporal dry mass development quantified in vitro by digital holographic microscopy

Auteurs: Kai Eder, Anne Marzi, Álvaro Barroso, Björn Kemper, Jürgen Schnekenburger
Publié dans: Quantitative Phase Imaging VII; 116531Q, Numéro Proceedings Volume 11653, 2021
Éditeur: SPIE
DOI: 10.1117/12.2577655

Perivascular Niche Based on Hyperbranched Laminin Dendron as a New Feasible Approach to Ameliorate Stemness Deprivation During In Vitro Expansion

Auteurs: Valeria Perugini, Matteo Santin
Publié dans: 30th European Society for Biomaterials Conference, 2019, Page(s) III-OS10-05 page 188
Éditeur: European Society for Biomaterials

Label-free in vitro quantification of medical nanoparticle effects on macrophages with digital holographic microscopy

Auteurs: Kai Moritz Eder, Anne Marzi, Alvaro Barroso, Björn Kemper, and Jürgen Schnekenburger
Publié dans: Imaging and Applied Optics Congress, OSA Technical Digest, Numéro Imaging and Applied Optics Congress, OSA Technical Digest (Optica Publishing Group, 2020), paper JW5A.4., 2020
Éditeur: OSA

Automated detection of macrophages in quantitative phase images by deep learning using a mask region-based convolutional neural network

Auteurs: Kai Eder, Tobias Kutscher, Anne Marzi, Álvaro Barroso, Jürgen Schnekenburger, Björn Kemper
Publié dans: Label-free Biomedical Imaging and Sensing, 2021
Éditeur: SPIE
DOI: 10.1117/12.2577232

Cell Detection and Segmentation in Quantitative Digital Holographic Phase Contrast Images Utilizing a Mask Region-based Convolutional Neural Network

Auteurs: Tobias Kutscher, Kai Eder, Anne Marzi, Álvaro Barroso, Jürgen Schnekenburger, and Björn Kemper
Publié dans: OSA Optical Sensors and Sensing Congress 2021, Numéro OSA Technical Digest (Optica Publishing Group, 2021), paper JTu5A.23., 2021
Éditeur: OSA

Synthetic Basement Membrane Analogues Induce the formation of 3D Tissue-like Structures in 2D Cultures

Auteurs: Matteo Santin (Invited Keynote Speaker)
Publié dans: Tissue Engineering and Regenerative Medicine International Societies (TERMIS) 2019, 2019, Page(s) 726
Éditeur: TERMIS

Reduction of the influence of parasitic interferences and coherence induced disturbances in digital holography-based quantitative phase microscopy by modulation of the object illumination with an electrically focus tunable lens

Auteurs: Kemper B., Barroso Á., Eder K., Marzi A., Ritz S., Schnekenburger J., Ketelhut S.
Publié dans: 2021
Éditeur: Progress in Biomedical Optics and Imaging - Proceedings of SPIE
DOI: 10.1117/12.2577807

Enhanced quantitative phase imaging in Mach-Zehnder interferometer-based digital holographic microscopy by modulation of the object illumination with an electrically focus tunable lens

Auteurs: Björn Kemper, Álvaro Barroso, Kai Eder, Anne Marzi, Sabrina Ritz, Angelos Ntovas, Jürgen Schnekenbürger, Steffi Ketelhut
Publié dans: Proceedings Volume 11786, Optical Methods for Inspection, Characterization, and Imaging of Biomaterials V; 117860I (2021), Numéro SPIE Optical Metrology, 2021, 2021
Éditeur: SPIE
DOI: 10.1117/12.2592534

Cytotoxicity of Medical Nanoparticles and Effects on Cell Dry Mass Dynamics Quantified in vitro by Digital Holographic Microscopy

Auteurs: Kai Moritz Eder
Publié dans: 2021
Éditeur: XXX

Nanomedicinal products: An integrated approach for immunotoxicity testing

Auteurs: Christina Giannakou
Publié dans: 2019
Éditeur: Maastricht University

Editorial to Special Issue

Auteurs: Kathleen Spring, Klaus-Michael Weltring, Adriele Prina-Mello, Ruth Schmid
Publié dans: Drug Delivery and Translational Research, 2022, ISSN 2190-393X
Éditeur: Springer Pub. Co.,

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