Objective
Brain development relies on formation of functional neuronal circuits. This requires coordinated migration of embryonic neurons and their cellular processes such as axons to the target regions and their selective connections with synaptic partners. The migration of neurons and axons is mediated by guidance cues. Combined interactions of multiple guidance cues with their receptors direct neurons and axons to their final destinations. So far our understating is limited to the effect of individual cues, which result in attractive or repulsive responses. How multiple cues influence neuron and axon migration remains elusive. In addition, interactions of multiple cues and receptors are poorly understood. Our group recently elucidated the structure of an octameric super-complex fragment consisting of FLRT proteins, adhesion GPCRs Latrophilin and guidance receptors Unc5. In this project, we will aim at elucidating the full length (including the transmembrane domains) structure of the super-complex to reveal the molecular details of the interactions. Further analysis of structure-function relationship of the super-complex will, for the first time, address how modular architecture of these medically important receptors influence their signaling functions. Expertise of the host, capacity of the researcher, multidisciplinary approach of the proposal and well-planned implementation and risk mitigation strategies will ensure successful completion of the project. The results will enhance competence of the researcher; collaboration opportunities and competitiveness of the host and contribute to the excellence of European research.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences biochemistry biomolecules proteins
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
OX1 2JD Oxford
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.