Objective
Phosphoinositides (PIs) are minor components of cell membranes, and play important roles in cellular functions. In chemical synapses in mammalian brain, each PI distributes different subcellular areas in nerve terminals, and cooperate with many proteins to regulate synaptic transmission machinery. To understand how PIs regulate synaptic transmission, the ultrastructural distribution pattern and dynamics of PIs at nerve terminals are crucial because PIs may functionally interact with proteins at domains of nano-meter ranges called active zones (AZs) or peri-AZs. However, their ultrastructural distribution and dynamics in nerve terminals are poorly investigated because of some technical difficulties. This research project aims to investigate (1) the ultrastructural distribution of PIs at AZs and peri-AZs in nerve terminals, (2) co-localization of PIs with presynaptic proteins related to synaptic transmission, (3) the ultrastructural dynamics of PIs and PI-protein coupling during synaptic transmission, and (4) the physiological roles of PI-protein couplings in synaptic transmission, using electron microscopic and electrophysiological techniques combined with optogenetics and biochemical tools. These highly-interdisciplinary approaches will unveil the physiological roles of PIs and PI-protein couplings in synaptic transmission, and is expected to give a fundamental breakthrough in understanding mechanisms of synaptic transmission.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3400 Klosterneuburg
Austria
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.