Objective
Cell polarity is essential for normal cell function and for various developmental processes, such as axis determination, asymmetric stem cell divisions, and cell migration. Polarity is integral for tissue organization and failure in this process is a hallmark of human malignancies.
Extensive studies in diverse model systems have helped to establish recurring mechanisms that drive polarity in various cell types. Yet, these conserved polarity regulators are not universally required and it emerges that some cells use distinct polarity mechanisms in a context dependent manner. For example, the polarization of the Drosophila intestinal epithelium does not require any of the canonical polarity regulators, unlike all other well-characterized Drosophila epithelia. However, little is known about how this unconventional polarity is established.
This proposal aims to elucidate novel alternative polarity pathways in the intestinal epithelium of Drosophila. I will conduct a large--scale forward genetic screen to identify novel polarity regulators in the fly gut epithelium. Furthermore, I will examine the functional conservation of the newly identified polarity regulators in the murine intestinal stem cell organoids. Overall, this proposal will shed novel insights into the epithelial biology of the intestinal system.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology cells technologies stem cells
- natural sciences biological sciences cell biology cell polarity
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
CB2 1TN CAMBRIDGE
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.