Objective
Sufficient sleep is a key determinant of health, and sleep loss is associated with severe health risks. Nevertheless, the reason for why we sleep is not yet understood. Recently, a molecular function of sleep was described in rodents. The ‘glymphatic system’ (GS) is a sleep dependent macroscopic pathway of the brain that facilitates the removal of metabolites, including amyloid-beta. This project will for the first time reveal a sleep-driven human GS and show whether glymphatic flow (GF) can be linked to cognitive impairments associated with sleep loss. Secondly, I will promote GF with the adrenergic antagonist Carvedilol. This manipulation of glymphatic clearance may define new approaches for treating sleep-disorders and Alzheimer’s disease, or reduce or delay our need for sleep.
I will investigate the human GS by applying state of the art, 5-10 Hz, ultra-fast MR sequences across sleep and wakefulness. Preliminary data show that these sequences enable the detection of cardiac, respiration, and slow pulsations, previously considered noise in fMRI imaging and distorted by aliasing effects. These pulsations are now believed to drive GF. The project will be a major step forward for sleep and neuroscience research, but also provide a key step in my career, demonstrating independent work and allowing me to learn advanced data-analysis skills and develop a novel imaging method, which I can apply in future studies. The chosen host institution is perfectly situated for the project, as they have established expertise and an exceptional skill-set in analyzing novel neuroimaging data including ultra-fast MRI. Secondly, my host provides unique infrastructure that allows for completion of the study, with key personnel in neuropsychology and data-analysis, as well as the world leading experts in glymphatic mechanisms. The project forms a foundation for a more general approach to integrate imaging of sleep-regulation and glymphatic mechanisms with patient or trait specific data.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences basic medicine neurology neurodegenerative diseases dementia alzheimer
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2017
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3400 Hillerod
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.