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Novel Bone Regeneration Drug Osteogrow: Therapeutic Solution for Lumbar Back Pain

Deliverables

Data Management Plan

"A data management plan will be developed in line with Guidelines on FAIR Data Management in Horizon 2020. The DMP covers the complete research data life cycle. It describes the types of data, that will be generated or collected during the project, the standards that will be used, how data will be preserved and what parts will be shared for verification or use. We are aware of sensitivity of clinical data related to personal data protection, as well as exploitation and licensing needs, so we shall keep certain data closed and stick with ""as open as possible, as closed as necessary"". This means that we will partially opt-out, but will prepare a DMP in accordance with the ORDP and GA Article 29. "

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Publications

Evaluation of synthetic ceramics as compression resistant matrix to promote osteogenesis of autologous blood coagulum containing recombinant human bone morphogenetic protein 6 in rabbit posterolateral lumbar fusion model

Author(s): Nikola Štoković, Natalia Ivanjko, Marko Pećin, Igor Erjavec, Sven Karlović, Ana Smajlović, Hrvoje Capak, Milan Milošević, Jadranka Bubić Špoljar, Dražen Vnuk, Dražen Matičić, Hermann Oppermann, T. Kuber Sampath, Slobodan Vukičević
Published in: Bone, Issue 140, 2020, Page(s) 115544, ISSN 8756-3282
DOI: 10.1016/j.bone.2020.115544

Bone morphogenetic proteins: From discovery to development of a novel autologous bone graft substitute consisting of recombinant human BMP6 delivered in autologous blood coagulum carrier

Author(s): Slobodan Vukičević, Mihaela Perić, Hermann Oppermann, Nikola Štoković, Natalia Ivanjko, Igor Erjavec, Vera Kufner, Dražen Vnuk, Jadranka Bubić Špoljar, Marko Pećin, Ruđer Novak, Ivona Matić Jelić, Kristian Bakić, Marina Milešević, Viktorija Rumenović, Irena Popek, Sanja Pehar, Snježana Martinović, Valentina Blažević, Lucija Rogina, Smiljka Vikić-Topić, Tamara Božić, Donatel
Published in: Rad Hrvatske akademije znanosti i umjetnosti. Medicinske znanosti, Issue 544/52-53, 2020, Page(s) 26-41, ISSN 1330-5301
DOI: 10.21857/mnlqgc5vgy

Autologous blood coagulum is a physiological carrier for BMP6 to induce new bone formation and promote posterolateral lumbar spine fusion in rabbits

Author(s): Slobodan Vukicevic, Lovorka Grgurevic, Igor Erjavec, Marko Pecin, Tatjana Bordukalo‐Niksic, Nikola Stokovic, Marija Lipar, Hrvoje Capak, Drazen Maticic, Reinhard Windhager, T. Kuber Sampath, Munish Gupta
Published in: Journal of Tissue Engineering and Regenerative Medicine, Issue 14/1, 2019, Page(s) 147-159, ISSN 1932-6254
DOI: 10.1002/term.2981

A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures

Author(s): Dragan Durdevic, Tomislav Vlahovic, Sanja Pehar, Dina Miklic, Hermann Oppermann, Tatjana Bordukalo-Niksic, Ismet Gavrankapetanovic, Mehmed Jamakosmanovic, Milan Milosevic, Snjezana Martinovic, T. Kuber Sampath, Mihaela Peric, Lovorka Grgurevic, Slobodan Vukicevic
Published in: Bone, Issue 140, 2020, Page(s) 115551, ISSN 8756-3282
DOI: 10.1016/j.bone.2020.115551

Autologous bone graft substitute containing rhBMP6 within autologous blood coagulum and synthetic ceramics of different particle size determines the quantity and structural pattern of bone formed in a rat subcutaneous assay

Author(s): Nikola Stokovic, Natalia Ivanjko, Igor Erjavec, Milan Milosevic, Hermann Oppermann, Larry Shimp, Kuber T. Sampath, Slobodan Vukicevic
Published in: Bone, Issue 141, 2020, Page(s) 115654, ISSN 8756-3282
DOI: 10.1016/j.bone.2020.115654

Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier

Author(s): T. Kuber Sampath, Slobodan Vukicevic
Published in: Bone, Issue 141, 2020, Page(s) 115602, ISSN 8756-3282
DOI: 10.1016/j.bone.2020.115602

Recombinant Human BMP6 Applied Within Autologous Blood Coagulum Accelerates Bone Healing: Randomized Controlled Trial in High Tibial Osteotomy Patients

Author(s): Catharina Chiari, Lovorka Grgurevic, Tatjana Bordukalo‐Niksic, Hermann Oppermann, Alexander Valentinitsch, Elena Nemecek, Kevin Staats, Markus Schreiner, Carmen Trost, Alexander Kolb, Franz Kainberger, Sanja Pehar, Milan Milosevic, Snjezana Martinovic, Mihaela Peric, T Kuber Sampath, Slobodan Vukicevic, Reinhard Windhager
Published in: Journal of Bone and Mineral Research, Issue 35/10, 2020, Page(s) 1893-1903, ISSN 0884-0431
DOI: 10.1002/jbmr.4107

Bone morphogenetic proteins in fracture repair

Author(s): Ivo Dumic-Cule, Mihaela Peric, Lucija Kucko, Lovorka Grgurevic, Marko Pecina, Slobodan Vukicevic
Published in: International Orthopaedics, Issue 42/11, 2018, Page(s) 2619-2626, ISSN 0341-2695
DOI: 10.1007/s00264-018-4153-y

Recombinant Human Bone Morphogenetic Protein 6 Delivered Within Autologous Blood Coagulum Restores Critical Size Segmental Defects of Ulna in Rabbits

Author(s): Lovorka Grgurevic, Hermann Oppermann, Marko Pecin, Igor Erjavec, Hrvoje Capak, Martina Pauk, Sven Karlovic, Vera Kufner, Marija Lipar, Jadranka Bubic Spoljar, Tatjana Bordukalo-Niksic, Drazen Maticic, Mihaela Peric, Reinhard Windhager, T Kuber Sampath, Slobodan Vukicevic
Published in: JBMR Plus, Issue 3/5, 2019, Page(s) e10085, ISSN 2473-4039
DOI: 10.1002/jbm4.10085

Autologous blood coagulum containing rhBMP6 induces new bone formation to promote anterior lumbar interbody fusion (ALIF) and posterolateral lumbar fusion (PLF) of spine in sheep

Author(s): Lovorka Grgurevic, Igor Erjavec, Munish Gupta, Marko Pecin, Tatjana Bordukalo-Niksic, Nikola Stokovic, Drazen Vnuk, Vladimir Farkas, Hrvoje Capak, Milan Milosevic, Jadranka Bubic Spoljar, Mihaela Peric, Mirta Vuckovic, Drazen Maticic, Reinhard Windhager, Hermann Oppermann, T. Kuber Sampath, Slobodan Vukicevic
Published in: Bone, Issue 138, 2020, Page(s) 115448, ISSN 8756-3282
DOI: 10.1016/j.bone.2020.115448

Synthetic ceramic macroporous blocks as a scaffold in ectopic bone formation induced by recombinant human bone morphogenetic protein 6 within autologous blood coagulum in rats

Author(s): Nikola Stokovic, Natalia Ivanjko, Marina Milesevic, Ivona Matic Jelic, Kristian Bakic, Viktorija Rumenovic, Hermann Oppermann, Larry Shimp, T. Kuber Sampath, Marko Pecina, Slobodan Vukicevic
Published in: International Orthopaedics, 2020, ISSN 0341-2695
DOI: 10.1007/s00264-020-04847-9

MolPharm/CABS 2018

Author(s): Slobodan Vukicevic, Lovorka Grgurevic
Published in: Journal of Bone Oncology, Issue 13, 2018, Page(s) 11-54, ISSN 2212-1374
DOI: 10.1016/j.jbo.2018.07.009