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Cypergenetic Tissue Engineering

Objective

This project addresses a serious bottleneck to the widespread availability of engineered tissues for clinical use: Currently, building of new tissues requires inefficient, manual manipulation that is time-consuming, labour-intensive and introduces high variability in the finished products. Relieving this limitation has implications for both health and wealth. The project will capitalize on the skills of its network of laboratories to build and demonstrate a technology for controlling the development of engineered tissues by optogenetics and closed-loop, self-correcting control. The core technology combines machine vision and computer modelling with optical feedback, through which the computer can alter the behaviour of precisely those cells that need to be stimulated/inhibited, for the tissue to develop toward the planned template. Optical sensitivity will be conferred on cells by synthetic biological techniques. One set of demonstrations will manipulate the growth and differentiation of these cells directly. A more advanced set will use light-sensitive production of signalling molecules by engineered cells to connect optical control to the control of normal, non-engineered cells as could be used for clinical tissue engineering, in 2- and in 3-dimensional systems. Our proposal includes plans for dissemination and academic, industrial and social impacts.

Field of science

  • /medical and health sciences/medical biotechnology/tissue engineering

Call for proposal

H2020-FETOPEN-1-2016-2017
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
Address
Raemistrasse 101
8092 Zuerich
Switzerland
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 2 506 250

Participants (4)

THE UNIVERSITY OF EDINBURGH
United Kingdom
EU contribution
€ 1 132 500
Address
Old College, South Bridge
EH8 9YL Edinburgh
Activity type
Higher or Secondary Education Establishments
HEINRICH-HEINE-UNIVERSITAET DUESSELDORF
Germany
EU contribution
€ 818 750
Address
Universitaetsstrasse 1
40225 Dusseldorf
Activity type
Higher or Secondary Education Establishments
WAGENINGEN UNIVERSITY

Participation ended

Netherlands
EU contribution
€ 0
Address
Droevendaalsesteeg 4
6708 PB Wageningen
Activity type
Higher or Secondary Education Establishments
KIRKSTALL LIMITED
United Kingdom
EU contribution
€ 238 750
Address
York House, Outgang Lane, Osbaldwic, York
YO19 5UP North Yorkshire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)