Modeling spontaneous Breast cancer metastasis TO the Bone with a first-of-its-kind 3D device that recapitulates physiological tissue-level complexity.

Project Information

B2B

Grant agreement ID: 801159

DOI 10.3030/801159

Project closed

EC signature date 25 May 2018

Start date 1 July 2018

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - Future and Emerging Technologies (FET)

Total cost € 3 799 371,25

EU contribution € 3 799 371,25

Coordinated by

CONSIGLIO NAZIONALE DELLE RICERCHE
Italy

Deliverables

Websites, patent fillings, videos etc. (1)

Website and logo

Design and development of website and logo for B2B project

Publications

Peer reviewed articles (16)

Bioprinting Vasculature: Materials, Cells and Emergent Techniques

Author(s): Clarissa Tomasina, Tristan Bodet, Carlos Mota, Lorenzo Moroni, Sandra Camarero-Espinosa
Published in: Materials, Issue 12/17, 2019, Page(s) 2701, ISSN 1996-1944
Publisher: MDPI Open Access Publishing
DOI: 10.3390/ma12172701

3D Perfusable Hydrogel Recapitulating the Cancer Dynamic Environment to in Vitro Investigate Metastatic Colonization

Author(s): Chiara Vitale, Arianna Fedi, Alessandra Marrella, Gabriele Varani, Marco Fato, Silvia Scaglione
Published in: Polymers, Issue 12/11, 2020, Page(s) 2467, ISSN 2073-4360
Publisher: MDPI
DOI: 10.3390/polym12112467

Therapeutic vascularization in regenerative medicine

Author(s): Roberto Gianni‐Barrera, Nunzia Di Maggio, Ludovic Melly, Maximilian G. Burger, Edin Mujagic, Lorenz Gürke, Dirk J. Schaefer, Andrea Banfi
Published in: STEM CELLS Translational Medicine, Issue 9/4, 2020, Page(s) 433-444, ISSN 2157-6564
Publisher: AlphaMed Press
DOI: 10.1002/sctm.19-0319

In vitro models replicating the human intestinal epithelium for absorption and metabolism studies: A systematic review.

Author(s): Arianna Fedi; Chiara Vitale; Giulia Ponschin; Seyoum Ayehunie; Marco Fato; Silvia Scaglione
Published in: Journal of Controlled Release, Issue 01683659, 2021, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2021.05.028

The osteo-angiogenic signaling crosstalk for bone regeneration: harmony out of complexity

Author(s): Nunzia Di Maggio; Andrea Banfi
Published in: Crossref, Issue 09581669, 2022, ISSN 0958-1669
Publisher: Elsevier BV
DOI: 10.1016/j.copbio.2022.102750

Clinical and Biological Aspects of Disseminated Tumor Cells and Dormancy in Breast Cancer

Author(s): Ring, Alexander; Spataro, Maria; Wicki, Andreas; Aceto, Nicola
Published in: Frontiers in Cell and Developmental Biology, 10, Issue 2296634X, 2022, ISSN 2296-634X
Publisher: Frontiers Media S.A.
DOI: 10.3389/fcell.2022.929893

Circulating Tumor Cell-Neutrophil Tango along the Metastatic Process

Author(s): Massimo Saini, Barbara M. Szczerba, Nicola Aceto
Published in: Cancer Research, Issue 79/24, 2019, Page(s) 6067-6073, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-19-1972

3D fluid-dynamic ovarian cancer model resembling systemic drug administration for efficacy assay

Author(s): Alessandra Marrella
Published in: ALTEX, 2020, ISSN 1868-596X
Publisher: Springer Spektrum | Springer-Verlag GmbH
DOI: 10.14573/altex.2003131

Cancer Diagnosis Using a Liquid Biopsy: Challenges and Expectations

Author(s): Francesc Castro-Giner, Sofia Gkountela, Cinzia Donato, Ilaria Alborelli, Luca Quagliata, Charlotte Ng, Salvatore Piscuoglio, Nicola Aceto
Published in: Diagnostics, Issue 8/2, 2018, Page(s) 31, ISSN 2075-4418
Publisher: https://www.mdpi.com
DOI: 10.3390/diagnostics8020031

To Be Taken in Count: Prostatic Tumor Cells Break Free upon Needle Biopsy

Author(s): Massimo Saini, Nicola Aceto
Published in: Clinical Chemistry, Issue 66/1, 2019, Page(s) 6-8, ISSN 0009-9147
Publisher: American Association for Clinical Chemistry, Inc.
DOI: 10.1373/clinchem.2019.311696

Tracking cancer progression: from circulating tumor cells to metastasis

Author(s): Francesc Castro-Giner, Nicola Aceto
Published in: Genome Medicine, Issue 12/1, 2020, ISSN 1756-994X
Publisher: BioMed Central
DOI: 10.1186/s13073-020-00728-3

Quantification of Protein Secretion from Circulating Tumor Cells in Microfluidic Chambers

Author(s): Lucas Armbrecht, Ophélie Rutschmann, Barbara Maria Szczerba, Jonas Nikoloff, Nicola Aceto, Petra S. Dittrich
Published in: Advanced Science, Issue 7/11, 2020, Page(s) 1903237, ISSN 2198-3844
Publisher: Wiley-VCH GmbH
DOI: 10.1002/advs.201903237

High blood flow shear stress values are associated with circulating tumor cells cluster disaggregation in a multi-channel microfluidic device

Author(s): Alessandra Marrella, Arianna Fedi, Gabriele Varani, Ivan Vaccari, Marco Fato, Giuseppe Firpo, Patrizia Guida, Nicola Aceto, Silvia Scaglione
Published in: PLOS ONE, Issue 16/1, 2021, Page(s) e0245536, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0245536

Hypoxia Triggers the Intravasation of Clustered Circulating Tumor Cells

Author(s): Cinzia Donato, Leo Kunz, Francesc Castro-Giner, Aino Paasinen-Sohns, Karin Strittmatter, Barbara Maria Szczerba, Ramona Scherrer, Nunzia Di Maggio, Wolf Heusermann, Oliver Biehlmaier, Christian Beisel, Marcus Vetter, Christoph Rochlitz, Walter Paul Weber, Andrea Banfi, Timm Schroeder, Nicola Aceto
Published in: Cell Reports, Issue 32/10, 2020, Page(s) 108105, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108105

An in vivo CRISPR screen identifies stepwise genetic dependencies of metastatic progression

Author(s): Manuel C. Scheidmann; Francesc Castro-Giner; Karin Strittmatter; Ilona Krol; Aino Paasinen-Sohns; Ramona Scherrer; Cinzia Donato; Sofia Gkountela; Barbara M. Szczerba; Zoi Diamantopoulou; Simone Muenst; Tatjana Vlajnic; Leo Kunz; Marcus Vetter; Christoph Rochlitz; Verdon Taylor; Claudio Giachino; Timm Schroeder; Randall J. Platt; Nicola Aceto
Published in: Cancer Res, Issue 00085472, 2021, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-21-3908

The metastatic spread of breast cancer accelerates during sleep

Author(s): Zoi Diamantopoulou; Francesc Castro-Giner; Fabienne Dominique Schwab; Christiane Foerster; Massimo Saini; Selina Budinjas; Karin Strittmatter; Ilona Krol; Bettina Seifert; Viola Heinzelmann-Schwarz; Christian Kurzeder; Christoph Rochlitz; Marcus Vetter; Walter Paul Weber; Nicola Aceto
Published in: Nature, 607 (7917), Issue 00280836, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04875-y

Non-peer reviewed articles (2)

Bring along your friends: Homotypic and heterotypic circulating tumor cell clustering to accelerate metastasis

Author(s): Nicola Aceto
Published in: Biomedical Journal, Issue 43/1, 2020, Page(s) 18-23, ISSN 2319-4170
Publisher: Medknow Publications and Media Pvt. Ltd
DOI: 10.1016/j.bj.2019.11.002

Circulating tumor cells: Ready for translation?

Author(s): Zoi Diamantopoulou, Francesc Castro-Giner, Nicola Aceto
Published in: Journal of Experimental Medicine, Issue 217/8, 2020, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20200356