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Decoding at systems-level the crosstalk between the T cell antigen receptor, the CD28 costimulator and the PD-1 coinhibitor under physiological and pathological conditions.

Deliverables

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Publications

ARHGAP45 controls naïve T‐ and B‐cell entry into lymph nodes and T‐cell progenitor thymus seeding

Author(s): Le He, Marie‐Pierre Valignat, Lichen Zhang, Lena Gelard, Fanghui Zhang, Valentin Le Guen, Stéphane Audebert, Luc Camoin, Even Fossum, Bjarne Bogen, Hui Wang, Sandrine Henri, Romain Roncagalli, Olivier Theodoly, Yinming Liang, Marie Malissen, Bernard Malissen
Published in: EMBO reports, 22/4, 2021, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202052196

Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen

Author(s): Christian Wohn, Valentin Le Guen, Odessa Voluzan, Frédéric Fiore, Sandrine Henri, Bernard Malissen
Published in: Science Immunology, 5/45, 2020, Page(s) eaba1896, ISSN 2470-9468
Publisher: American Association for the Advancement of Science.
DOI: 10.1126/sciimmunol.aba1896

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN 2 as a regulator of effector functions

Author(s): Marie Locard‐Paulet, Guillaume Voisinne, Carine Froment, Marisa Goncalves Menoita, Youcef Ounoughene, Laura Girard, Claude Gregoire, Daiki Mori, Manuel Martinez, Hervé Luche, Jerôme Garin, Marie Malissen, Odile Burlet‐Schiltz, Bernard Malissen, Anne Gonzalez de Peredo, Romain Roncagalli
Published in: Molecular Systems Biology, 16/7, 2020, ISSN 1744-4292
Publisher: Nature Publishing Group
DOI: 10.15252/msb.20209524

Opposing regulatory functions of the TIM3 (HAVCR2) signalosome in primary effector T cells as revealed by quantitative interactomics

Author(s): Yunhao Zhai, Javier Celis-Gutierrez, Guillaume Voisinne, Daiki Mori, Laura Girard, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Romain Roncagalli, Bernard Malissen
Published in: Cellular & Molecular Immunology, 18/6, 2021, Page(s) 1581-1583, ISSN 1672-7681
Publisher: Nature Publishing Group
DOI: 10.1038/s41423-020-00575-7

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Author(s): Javier Celis-Gutierrez, Peter Blattmann, Yunhao Zhai, Nicolas Jarmuzynski, Kilian Ruminski, Claude Grégoire, Youcef Ounoughene, Frédéric Fiore, Ruedi Aebersold, Romain Roncagalli, Matthias Gstaiger, Bernard Malissen
Published in: Cell Reports, 27/11, 2019, Page(s) 3315-3330.e7, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.05.041

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Author(s): Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen
Published in: Nature Immunology, 20/11, 2019, Page(s) 1530-1541, ISSN 1529-2908
Publisher: Nature Publishing Group
DOI: 10.1038/s41590-019-0489-8

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

Author(s): Daiki Mori, Claude Grégoire, Guillaume Voisinne, Javier Celis-Gutierrez, Rudy Aussel, Laura Girard, Mylène Camus, Marlène Marcellin, Jérémy Argenty, Odile Burlet-Schiltz, Frédéric Fiore, Anne Gonzalez de Peredo, Marie Malissen, Romain Roncagalli, Bernard Malissen
Published in: Journal of Experimental Medicine, 218/2, 2021, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20201011

Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen

Author(s): Christian Wohn, Valentin Le Guen, Odessa Voluzan , Frédéric Fiore , Sandrine Henri, Bernard Malissen
Published in: Science Immunology, 2020, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciimmunol.aba1896

Systems-level conservation of the proximal TCR signaling network of mice and humans

Author(s): Philippe Nicolas, Jocelyn Ollier, Daiki Mori, Guillaume Voisinne, Javier Celis-Guttierez, Claude Gregoire, Jeanne Perroteau, Régine Vivien, Mylène Camus, Odile Burlet-Schiltz, Anne Gonzalez de Peredo, Béatrice Clémenceau, Romain Roncagalli, Henri Vié, and Bernard Malissen
Published in: Journal of Experimental Medicine, 2022, ISSN 0022-1007
Publisher: Rockefeller University Press
DOI: 10.1084/jem.20211295