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Decoding at systems-level the crosstalk between the T cell antigen receptor, the CD28 costimulator and the PD-1 coinhibitor under physiological and pathological conditions.

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Absence of MHC class II on cDC1 dendritic cells triggers fatal autoimmunity to a cross-presented self-antigen

Author(s): Christian Wohn, Valentin Le Guen, Odessa Voluzan, Frédéric Fiore, Sandrine Henri, Bernard Malissen
Published in: Science Immunology, Issue 5/45, 2020, Page(s) eaba1896, ISSN 2470-9468
DOI: 10.1126/sciimmunol.aba1896

LymphoAtlas: a dynamic and integrated phosphoproteomic resource of TCR signaling in primary T cells reveals ITSN 2 as a regulator of effector functions

Author(s): Marie Locard‐Paulet, Guillaume Voisinne, Carine Froment, Marisa Goncalves Menoita, Youcef Ounoughene, Laura Girard, Claude Gregoire, Daiki Mori, Manuel Martinez, Hervé Luche, Jerôme Garin, Marie Malissen, Odile Burlet‐Schiltz, Bernard Malissen, Anne Gonzalez de Peredo, Romain Roncagalli
Published in: Molecular Systems Biology, Issue 16/7, 2020, ISSN 1744-4292
DOI: 10.15252/msb.20209524

Quantitative Interactomics in Primary T Cells Provides a Rationale for Concomitant PD-1 and BTLA Coinhibitor Blockade in Cancer Immunotherapy

Author(s): Javier Celis-Gutierrez, Peter Blattmann, Yunhao Zhai, Nicolas Jarmuzynski, Kilian Ruminski, Claude Grégoire, Youcef Ounoughene, Frédéric Fiore, Ruedi Aebersold, Romain Roncagalli, Matthias Gstaiger, Bernard Malissen
Published in: Cell Reports, Issue 27/11, 2019, Page(s) 3315-3330.e7, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.05.041

Quantitative interactomics in primary T cells unveils TCR signal diversification extent and dynamics

Author(s): Guillaume Voisinne, Kristof Kersse, Karima Chaoui, Liaoxun Lu, Julie Chaix, Lichen Zhang, Marisa Goncalves Menoita, Laura Girard, Youcef Ounoughene, Hui Wang, Odile Burlet-Schiltz, Hervé Luche, Frédéric Fiore, Marie Malissen, Anne Gonzalez de Peredo, Yinming Liang, Romain Roncagalli, Bernard Malissen
Published in: Nature Immunology, Issue 20/11, 2019, Page(s) 1530-1541, ISSN 1529-2908
DOI: 10.1038/s41590-019-0489-8

The T cell CD6 receptor operates a multitask signalosome with opposite functions in T cell activation

Author(s): Daiki Mori, Claude Grégoire, Guillaume Voisinne, Javier Celis-Gutierrez, Rudy Aussel, Laura Girard, Mylène Camus, Marlène Marcellin, Jérémy Argenty, Odile Burlet-Schiltz, Frédéric Fiore, Anne Gonzalez de Peredo, Marie Malissen, Romain Roncagalli, Bernard Malissen
Published in: Journal of Experimental Medicine, Issue 218/2, 2021, ISSN 0022-1007
DOI: 10.1084/jem.20201011