Project description
Green medicinal chemistry
The carbon–carbon bond forms the basic skeleton of an organic compound, and its synthesis is of paramount importance for the pharmaceutical industry. Formation of the carbon–carbon bond is catalysed through cross-coupling reactions by metals such as palladium. The environmental impact of these reactions urged scientists of the EU-funded CC-Coupler project to look for greener alternatives. To that end, they have generated a novel catalyst-based technology that is cost-effective and environmentally sustainable yet demonstrates high-performance organic synthesis. Implementation of this technology is expected to lead to the synthesis of new compounds for medicinal purposes.
Objective
Pharmaceutical industry needs environmentally cleaner processes. One of the most important family of chemical reaction is the formation of carbon-carbon bond by Pd mediated C-C coupling. It is estimated, that more than 50% of new drug synthesis will include at least one C-C coupling reactions. However, there are several issues regarding this reaction related to high environmental impact, complicated processes due to air-sensitive catalyst, post-processing, solvent issues, and catalyst recovery. We have developed a new integrated approach for carrying out C-C coupling reactions in an environmental benign and cost-effective way. Our CC-Coupler method targets to overcome all the issues regarding the reaction. Our aim is to commercialise the CC-Coupler as an integrated technology, providing an air-stable, highly performant catalyst with an adequate flow-chemistry device and parameter set optimised for the clients’ needs. In this Phase 1 project, as a first step, we shall carry out a feasibility assessment. The success of this project will promote the growth of our company and make a step towards cleaner pharmaceutical industry.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques.
- medical and health sciencesbasic medicinepharmacology and pharmacydrug discovery
- medical and health sciencesbasic medicinemedicinal chemistry
- natural scienceschemical sciencescatalysis
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Programme(s)
Funding Scheme
SME-1 - SME instrument phase 1Coordinator
1025 BUDAPEST
Hungary
The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.