Project description DEENESFRITPL Mechanistic insight into mental disorders Accumulating evidence indicates that mental disorders such as autism and schizophrenia are characterised by dysfunctional connectivity in the brain. The aim of the EU-funded Syn2Psy project is to train early-stage researchers to address fundamental questions regarding neuropsychiatric disorders. The rationale is to investigate synaptic defects and design strategies that target specific neuronal circuits as a means of modulating the course of the disease. Researchers will develop new disease models to study the pathways that regulate synapse development and plasticity alongside potential therapeutic interventions. The industrial partners of the project will offer expertise in drug and technology development. Show the project objective Hide the project objective Objective The large public health burden and individual suffering associated with mental disorders speaks to the need to study their biological underpinning. Genetic research, animal models of disease and human neuroimaging studies have provided convergent evidence to common pathways implicated in their aetiology, namely pathways that regulate synapse development and plasticity, which result in abnormal structural and functional connectivity in the brain of neuropsychiatric patients. The time has come to integrate studies across different levels, leading to the identification of signatures of illness associated to specific risk pathways, which can drive the development of novel therapies.The objective of Syn2Psy is to provide high-level Ph.D. training for 14 early stage researchers (ESRs) to answer three critical questions: 1) What are the synaptic defects at the basis of neuropsychiatric disorders? 2) Which are the neuronal circuits that are disrupted, and may be targets for therapies? 3) How and when can we modulate the course of disease? Syn2Psy combines strong scientific with complementary know-how from the non-academic sector, and network-wide actions on scientific and complementary soft skills, to train a new generation of high achieving ESRs and provide them with the transferable skills necessary for thriving careers in a flourishing area. Industrial partners Lundbeck, Eurotrials and ZEISS provide experience on drug, clinical trials and technology development, the Coimbra University Hospital will expose the students to clinical research, while the clinic for child development PIN and the Marionet theatre company offer training in societal awareness and outreach. The excellent basic scientific knowledge and diverse skills acquired by ESRs will enhance their employment prospects in both the academic and non-academic sectors, and their scientific contributions will inform novel therapeutic approaches for alleviating this leading cause of disability worldwide. Fields of science natural sciencesbiological sciencesneurobiologyhumanitiesartsperforming artsdramaturgysocial scienceseconomics and businessbusiness and managementemployment Keywords Neuropsychiatric disorders Synaptic dysfunction Genetic animal models of disease Rational therapies Neuromodulators Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.1. - Fostering new skills by means of excellent initial training of researchers Topic(s) MSCA-ITN-2018 - Innovative Training Networks Call for proposal H2020-MSCA-ITN-2018 See other projects for this call Funding Scheme MSCA-ITN - Marie Skłodowska-Curie Innovative Training Networks (ITN) Coordinator CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO Net EU contribution € 713 160,72 Address Universidade de coimbra largo marques de pombal 3004 517 Coimbra Portugal See on map Region Continente Centro (PT) Região de Coimbra Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 713 160,72 Participants (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 1 035 087,68 Address Rue michel ange 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 035 087,68 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Switzerland Net EU contribution € 562 553,28 Address Batiment ce 3316 station 1 1015 Lausanne See on map Region Schweiz/Suisse/Svizzera Région lémanique Vaud Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 562 553,28 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE United Kingdom Net EU contribution € 606 345,12 Address South kensington campus exhibition road SW7 2AZ London See on map Region London Inner London — West Westminster Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 606 345,12 THE UNIVERSITY OF EDINBURGH United Kingdom Net EU contribution € 670 465,28 Address Old college, south bridge EH8 9YL Edinburgh See on map Region Scotland Eastern Scotland Edinburgh Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 670 465,28 H. LUNDBECK AS Denmark Net EU contribution € 297 522,00 Address Ottiliavej 7-9 2500 Valby See on map Region Danmark Hovedstaden Byen København Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 297 522,00 Partners (5) Sort alphabetically Sort by Net EU contribution Expand all Collapse all Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. MARIONET-ASSOCIACAO CULTURAL Portugal Net EU contribution € 0,00 Address 90 av. emidio navarro 5 esq 3000 151 Coimbra See on map Region Continente Centro (PT) Região de Coimbra Activity type Other Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. PIN - Progresso Infantil Portugal Net EU contribution € 0,00 Address Rua calvet de magalhães, 244 - 0 2770 - 022 Paço de arcos See on map Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. CENTRO HOSPITALAR E UNIVERSITARIO DE COIMBRA EPE Portugal Net EU contribution € 0,00 Address Av de bissaya, praceta de mota pinto 3000-075 Coimbra See on map Region Continente Centro (PT) Região de Coimbra Activity type Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. Eurotrials Scientific Consultants Portugal Net EU contribution € 0,00 Address Rua tierno galvan, torre 3, piso 16 1070-274 Lisboa See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Continente Área Metropolitana de Lisboa Área Metropolitana de Lisboa Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data Partner Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement. CARL ZEISS SMS GMBH Germany Net EU contribution € 0,00 Address Carl zeiss promenade 10 07745 Jena See on map Region Thüringen Thüringen Jena, Kreisfreie Stadt Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost No data