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A neuroprosthesis to restore the vagal-cardiac closed-loop connection after heart transplantation

Project description

Neuroprosthetic restoration of neural control in the transplanted heart

Heart transplantation (HT) is the last resort for patients with end-stage heart failure. However, while it increases life expectancy, the quality of life of HT recipients is still limited. Late complications occur mainly due to chronotropic incompetence associated with cardiac denervation. Orthotopic heart transplantation (OHT), the most common technique used, involves the complete surgical denervation of the heart, leading to significant modulation of the rate- and load-contractility relationship of the donor's heart. The EU-funded NeuHeart project aims to develop a bioelectronic solution based on integrated cardiac smart neuroprosthesis. This approach will be tested in a preclinical model of OHT to demonstrate the feasibility of re-establishing vagal control in a denervated heart by re-enabling the heart–vagus nerve closed-loop connection.

Call for proposal

H2020-FETPROACT-2018-2020

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Sub call

H2020-FETPROACT-2018-01

Coordinator

SCUOLA SUPERIORE DI STUDI UNIVERSITARI E DI PERFEZIONAMENTO S ANNA
Net EU contribution
€ 1 528 250,00
Address
Piazza Martiri Della Liberta 33
56127 Pisa
Italy

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Region
Centro (IT) Toscana Pisa
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00

Participants (5)

UNIVERSITY COLLEGE LONDON
United Kingdom
Net EU contribution
€ 1 036 287,50
Address
Gower Street
WC1E 6BT London

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Region
London Inner London — West Camden and City of London
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
MEDIZINISCHE UNIVERSITAET WIEN
Austria
Net EU contribution
€ 695 977,50
Address
Spitalgasse 23
1090 Wien

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Region
Wien Wien
Activity type
Higher or Secondary Education Establishments
Other funding
€ 0,00
FORSCHUNGSSTIFTUNG FUR INFORMATIONSTECHNOLOGIE UND GESELLSCHAFT
Switzerland
Net EU contribution
€ 724 705,00
Address
Zeughausstrasse 43
8004 Zurich

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Region
Schweiz/Suisse/Svizzera Zürich Zürich
Activity type
Research Organisations
Other funding
€ 0,00
FRAUNHOFER GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG EV
Germany
Net EU contribution
€ 600 745,00
Address
Hansastrasse 27c
80686 Munchen

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Region
Bayern Oberbayern München, Kreisfreie Stadt
Activity type
Research Organisations
Other funding
€ 0,00
SENSARS NEUROPROSTHETICS SARL
Switzerland
Net EU contribution
€ 397 500,00
Address
Rue Du Maupas 38
1004 Lausanne

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Schweiz/Suisse/Svizzera Région lémanique Vaud
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Other funding
€ 0,00