CORDIS
EU research results

CORDIS

English EN

Hybrid Enhanced Regenerative Medicine Systems

Objective

Brain disorders are the most invalidating condition, exceeding HIV, cancer and heart ischemia, with significant impact on society and public health. Regenerative medicine is a promising branch of health science that aims at restoring brain function by rebuilding brain tissue. However, repairing the brain is one of the hardest challenges and we are still unable to effectively rebuild brain matter. Epilepsy is particularly challenging due to its dynamic nature caused by the relentless brain damage and aberrant rearrangements of brain rewiring. To overcome the biological uncertainty of canonical regenerative approaches, we propose an innovative solution based on intelligent biohybrids, made by the symbiotic integration of bioengineered brain tissue, neuromorphic microelectronics and artificial intelligence, to effectively drive self-repair of dysfunctional brain circuits and we validate it against animal models of epilepsy. HERMES fosters the emergence of a novel biomedical paradigm, rooted in the use of biohybrid neuronics (neural electronics), which we name enhanced regenerative medicine. To this end, HERMES will promote interdisciplinary cross-fertilization within and outside the consortium; it will extend the concepts of enhanced brain regeneration to philosophy, ethics, policy and society to foster the emergence of a new innovation eco-system. Intelligent biohybrids will represent a major breakthrough to advance brain repair research beyond regenerative medicine and neurotechnology alone; it will bring new knowledge in neurobiology, cognitive neuroscience and philosophy, and new neuromorphic technology and AI algorithms. HERMES will bring a giant conceptual leap that will shift the concept of biomedical interventions from treating to healing. In turn, it will potentially generate major returns on health care and society at large by bringing previously unimaginable possibilities to defeat disorders that represent today a global major burden of disease.

Coordinator

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Address

Via Morego 30
16163 Genova

Italy

Activity type

Research Organisations

EU Contribution

€ 1 830 812,50

Participants (12)

Sort alphabetically

Sort by EU Contribution

Expand all

UNIVERSITA DEGLI STUDI DI MODENA E REGGIO EMILIA

Italy

EU Contribution

€ 1 148 827,50

UNIVERSITA DEGLI STUDI DI VERONA

Italy

EU Contribution

€ 751 096,25

AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS

Spain

EU Contribution

€ 438 511,25

POLITECNICO DI MILANO

Italy

EU Contribution

€ 819 056,25

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 836 090

UNIVERSITY OF GLASGOW

United Kingdom

EU Contribution

€ 568 547,50

TTY-SAATIO

Finland

TAMPEREEN KORKEAKOULUSAATIO SR

Finland

EU Contribution

€ 818 437,50

FUNDACION INSTITUTO DE ESTUDIOS DE CIENCIAS DE LA SALUD DE CASTILLA Y LEON

Spain

EU Contribution

€ 416 603,75

EUROKLEIS SRL

Italy

EU Contribution

€ 245 875

STICHTING KATHOLIEKE UNIVERSITEIT

Netherlands

EU Contribution

€ 252 875

DEN INSTITUTE

Belgium

EU Contribution

€ 303 125

Project information

Grant agreement ID: 824164

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2023

Funded under:

H2020-EU.1.2.2.

  • Overall budget:

    € 8 429 857,50

  • EU contribution

    € 8 429 857,50

Coordinated by:

FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Italy