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NEw Clinical Endpoints in primary Sjögren’s Syndrome: an Interventional Trial based on stratifYing patients

Project description

Novel biomarkers for stratifying patients with primary Sjögren’s syndrome

Primary Sjögren’s syndrome (pSS) is a systemic autoimmune disease (AID) presenting with heterogeneous clinical manifestations and biological disturbances. It primarily affects exocrine glands leading to dryness of the eyes and the mouth, but it can also cause kidney or lung disease. The multi-organ impact of pSS has hampered drug discovery with only one licensed drug in the last 20 years. Scientists of the EU-funded NECESSITY project will assist in drug-discovery efforts by determining sensitive clinical endpoints, for use in future clinical trials involving patients with pSS. Through a clinical trial, they will evaluate these endpoints alongside discriminative biomarkers for the stratification of patients with pSS.

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 877 016,25
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,25

Participants (28)

Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITE PARIS-SACLAY
France
Net EU contribution
€ 356 818,50
Address
Batiment Breguet - 3 Rue Joliot Curie
91190 Gif-sur-yvette

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Region
Ile-de-France Ile-de-France Essonne
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
THE UNIVERSITY OF BIRMINGHAM
United Kingdom
Net EU contribution
€ 643 394,25
Address
Edgbaston
B15 2TT Birmingham

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
KAROLINSKA INSTITUTET
Sweden
Net EU contribution
€ 220 000,00
Address
Nobels Vag 5
17177 Stockholm

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Region
Östra Sverige Stockholm Stockholms län
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITY OF NEWCASTLE UPON TYNE
United Kingdom
Net EU contribution
€ 380 572,50
Address
Kings Gate
NE1 7RU Newcastle Upon Tyne

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Region
North East (England) Northumberland and Tyne and Wear Tyneside
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
HOPITAUX UNIVERSITAIRES DE STRASBOURG
France
Net EU contribution
€ 300 000,00
Address
Place De L Hopital 1
67091 Strasbourg Cedex

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Region
Grand Est Alsace Bas-Rhin
Activity type
Research Organisations
Non-EU contribution
€ 0,00
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Netherlands
Net EU contribution
€ 140 225,00
Address
Heidelberglaan 100
3584 CX Utrecht

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Region
West-Nederland Utrecht Utrecht
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITE DE BRETAGNE OCCIDENTALE
France
Net EU contribution
€ 371 311,25
Address
Rue Des Archives 3
29238 Brest

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Region
Bretagne Bretagne Finistère
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 60 000,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE BREST
France
Net EU contribution
€ 18 675,00
Address
Avenue Marechal Foch 5
29609 Brest

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Region
Bretagne Bretagne Finistère
Activity type
Research Organisations
Non-EU contribution
€ 0,00
FUNDACION PUBLICA ANDALUZA PROGRESO Y SALUD
Spain
Net EU contribution
€ 50 000,00
Address
Avenida Americo Vespucio 15 Edif S2
41092 Sevilla

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Region
Andalucía Sevilla
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
Greece
Net EU contribution
€ 100 000,00
Address
6 Christou Lada Str
10561 Athina

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Region
Κεντρικός Τομέας Αθηνών Aττική Αττική
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITE PARIS CITE
France
Net EU contribution
€ 596 848,75
Address
85 Bd Saint Germain
75006 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
Net EU contribution
€ 2 096 640,00
Address
3 Avenue Victoria
75000 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
Net EU contribution
€ 621 696,00
Address
5 Rue Watt
75013 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK
Ireland
Net EU contribution
€ 191 438,00
Address
Western Road
T12 YN60 Cork

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Region
Ireland Eastern and Midland Dublin
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITETET I BERGEN

Participation ended

Norway
Net EU contribution
€ 19 772,00
Address
Museplassen 1
5020 Bergen

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Region
Norge Vestlandet Vestland
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INNOVATION ACTA S.R.L.
Italy
Net EU contribution
€ 300 000,00
Address
Via D.a. Azuni, 9
00196 Roma

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Centro (IT) Lazio Roma
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
ASSOCIATION FRANCAISE GOUGEROT-SJOGREN
France
Net EU contribution
€ 50 000,00
Address
11 Rue De L'evangile
75018 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Other
Non-EU contribution
€ 0,00
QUEEN MARY UNIVERSITY OF LONDON
United Kingdom
Net EU contribution
€ 250 973,75
Address
327 Mile End Road
E1 4NS London

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Region
London Inner London — East Tower Hamlets
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITA DEGLI STUDI DI UDINE
Italy
Net EU contribution
€ 100 000,00
Address
Via Palladio 8
33100 Udine

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Region
Nord-Est Friuli-Venezia Giulia Udine
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
INSTITUT PASTEUR
France
Net EU contribution
€ 118 732,50
Address
Rue Du Docteur Roux 25-28
75724 Paris Cedex 15

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
HELSE STAVANGER HF
Norway
Net EU contribution
€ 87 500,00
Address
Gerd Ragna Bloch Thorsens Gate 8
4011 Stavanger

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Region
Norge Vestlandet Rogaland
Activity type
Other
Non-EU contribution
€ 0,00
ACADEMISCH ZIEKENHUIS GRONINGEN
Netherlands
Net EU contribution
€ 100 767,50
Address
Hanzeplein 1
9713 GZ Groningen

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Region
Noord-Nederland Groningen Overig Groningen
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
FUNDACIO CLINIC PER A LA RECERCA BIOMEDICA
Spain
Net EU contribution
€ 207 618,75
Address
Carrer Rossello 149
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

HOSPITAL CLINIC DE BARCELONA
Spain
Net EU contribution
€ 0,00
Address
Calle Villarroel 170
08036 Barcelona

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Region
Este Cataluña Barcelona
Activity type
Research Organisations
Non-EU contribution
€ 0,00
NOVARTIS PHARMA AG
Switzerland
Net EU contribution
€ 0,00
Address
Lichtstrasse 35
4056 Basel

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Region
Schweiz/Suisse/Svizzera Nordwestschweiz Basel-Stadt
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 3 220 000,00
GLAXOSMITHKLINE RESEARCH AND DEVELOPMENT LTD.
United Kingdom
Net EU contribution
€ 0,00
Address
Great West Road 980
TW89GS Brentford

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Region
London Outer London — West and North West Hounslow and Richmond upon Thames
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 1 000 020,00
BRISTOL-MYERS SQUIBB COMPANY CORP
United States
Net EU contribution
€ 0,00
Address
Park Avenue 345
10154 New York

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Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 2 000 000,00
INSTITUT DE RECHERCHES INTERNATIONALES SERVIER IRIS
France
Net EU contribution
€ 0,00
Address
Rue Carnot 50
92284 Courbevoie

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Region
Ile-de-France Ile-de-France Hauts-de-Seine
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 945 000,00