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INnovative chemIcal sensors for enanTioselective detectIon of chiral pOllutants

Project description

Novel chemical sensor detects chiral compounds in real time

Chiral chemicals – comprising molecules that cannot be superimposed on their mirror image – are increasingly being used for manufacturing pharmaceuticals, agrochemicals, food ingredients and perfumes. The disposal of chiral compounds can pose a threat to the environment owing to their high biological activity. The EU-funded INITIO project plans to develop a portable chemical sensor that can analyse and discriminate chiral molecules on site and in real time. Unlike current chemical sensors, the proposed technology features suitable solid-state receptors (based on porphyrin derivatives) that can reliably analyse the content of chiral waste.

Objective

Chiral pollution is an environmental topic of crucial importance, considering that a large number of chemicals spreading into the environment, for example pesticides, are chiral substances. However, usually the stereoisomerism of contaminants is not considered, although the biological activity of enantiomers is significantly different, making their recognition critical for environmental control. Enantiomeric excess is currently determined by off-site analysis, requiring collection, transportation, eventual pre-treating of the sample, and expensive instrumentations and specifically trained staff. Thus, providing devices able to allow for rapid on site detection and chiral discrimination of target analytes would have a dramatic impact in all the fields of environmental control with significant economic benefits. The development of chemical sensors has been conceived to bypass restrictions related to classical analytical protocols and supports the use of conventional laboratory techniques for environmental control. While the technological foundation for chemical sensors already exists, it has been difficult to apply them to chiral discrimination and analysis, due to the lack of suitable solid state receptors. The main aims of the project are: a) the development of novel molecular receptors, mainly based on porphyrin derivatives, b) integration of the receptors with different nanostructures and characterization of their solid state organization, c) deposition of the structures onto transducer surfaces, d) testing and validation of the new chemical sensor devices with enantiomeric pairs of model analytes. The synergistic complementary know-how of six academic units and two private companies will allow a breakthrough development through delivery of sensing probes ranging from the synthesis of macrocyclic molecular receptors to the building and testing of analytical and electronic parts for final, field-capable devices.

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Topic(s)

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Funding Scheme

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RIA - Research and Innovation action

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Call for proposal

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(opens in new window) H2020-FETOPEN-2018-2020

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Coordinator

UNIVERSITA DEGLI STUDI DI ROMA TOR VERGATA
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 593 750,00
Address
VIA CRACOVIA 50
00133 Roma
Italy

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Region
Centro (IT) Lazio Roma
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 593 750,00

Participants (8)

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