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Well-Aging and the Tanycytic Control of Health

Project description

Role of glial cells tanycytes in healthy ageing

The organisms' survival depends on energy homeostasis, involving the control of neuroendocrine functions that integrate metabolic feedback. Tanycytes are glial cells lining the floor of the third ventricle in the median eminence of the hypothalamus which control the secretion of neuropeptides by hypothalamic neurons into the pituitary portal circulation and regulate blood-brain and blood-cerebrospinal fluid exchanges. Tanycytes actively shuttle metabolic signals to hypothalamic neurons that control food intake. The goal of the EU-funded WATCH project is to employ state-of-the-art technologies in systems neuroscience, mouse genetics, and translational research, to elucidate the role of tanycytes and provide new directions in biomarker research and therapeutic approaches for a variety of disorders that impair healthy ageing.

Host institution

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Net EU contribution
€ 4 243 750,00
Address
Rue De Tolbiac 101
75654 Paris
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00

Beneficiaries (4)

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
Net EU contribution
€ 4 243 750,00
Address
Rue De Tolbiac 101
75654 Paris

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Non-EU contribution
€ 0,00
Third-party

Legal entity other than a subcontractor which is affiliated or legally linked to a participant. The entity carries out work under the conditions laid down in the Grant Agreement, supplies goods or provides services for the action, but did not sign the Grant Agreement. A third party abides by the rules applicable to its related participant under the Grant Agreement with regard to eligibility of costs and control of expenditure.

CENTRE HOSPITALIER REGIONAL ET UNIVERSITAIRE DE LILLE
France
Net EU contribution
€ 250 000,00
Address
Avenue Oscar Lambret 2
59037 Lille

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Region
Hauts-de-France Nord-Pas de Calais Nord
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSITAET zu LUEBECK
Germany
Net EU contribution
€ 2 875 000,00
Address
Ratzeburger Allee 160
23562 Lubeck

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Region
Baden-Württemberg Stuttgart Stuttgart, Stadtkreis
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
Net EU contribution
€ 2 497 500,00
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela

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Region
Galicia A Coruña
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00