Well-Aging and the Tanycytic Control of Health

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Inhibition of ATG3 ameliorates liver steatosis by increasing mitochondrial function

Author(s): Natália da Silva Lima, Marcos F Fondevila, Eva Nóvoa, Xabier Buqué, Maria Mercado-Gómez, Sarah Gallet, Maria J González-Rellan, Uxia Fernandez, Anne Loyens, Maria Garcia-Vence, Maria Del Pilar Chantada-Vazquez, Susana B Bravo, Patricia Marañon, Ana Senra, Adriana Escudero, Magdalena Leiva, Diana Guallar, Miguel Fidalgo, Pedro Gomes, Marc Claret, Guadalupe Sabio, Marta Varela-Rey, Teresa C De
Published in: J. Hepatol., Issue 2022 Jan;76(1, 2022, Page(s) 11-24, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2021.09.008

Obesity induces resistance to central action of BMP8B through a mechanism involving the BBSome

Author(s): Eva Rial-Pensado, Oscar Freire-Agulleiro, Marcos Ríos, Deng Fu Guo, Cristina Contreras, Patricia Seoane-Collazo, Sulay Tovar, Rubén Nogueiras, Carlos Diéguez, Kamal Rahmouni, Miguel López
Published in: Molecular Metabolism, Issue 59, 2024, Page(s) 101465, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2022.101465

Activation of Hypothalamic <scp>AMP‐Activated</scp> Protein Kinase Ameliorates Metabolic Complications of Experimental Arthritis

Author(s): Patricia Seoane‐Collazo, Eva Rial‐Pensado, Ánxela Estévez‐Salguero, Edward Milbank, Lucía García‐Caballero, Marcos Ríos, Laura Liñares‐Pose, Morena Scotece, Rosalía Gallego, José Manuel Fernández‐Real, Rubén Nogueiras, Carlos Diéguez, Oreste Gualillo, Miguel López
Published in: Arthritis & Rheumatology, Issue 74, 2023, Page(s) 212-222, ISSN 2326-5191
Publisher: Wiley
DOI: 10.1002/art.41950

MS2 and LC libraries for untargeted metabolomics: Enhancing method development and identification confidence

Author(s): Julica Folberth, Kimberly Begemann, Olaf Jöhren, Markus Schwaninger, Alaa Othman
Published in: Journal of Chromatography B, Issue 1145, 2020, Page(s) 122105, ISSN 1570-0232
Publisher: Elsevier BV
DOI: 10.1016/j.jchromb.2020.122105

Protocol for simultaneous patch-clamp recording from tanycytes and neurons in living mouse brain slices

Author(s): Tori Lhomme, Vincent Prévot
Published in: STAR Protocols, Issue 4, 2025, Page(s) 102571, ISSN 2666-1667
Publisher: Elsevier BV
DOI: 10.1016/j.xpro.2023.102571

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels.

Author(s): Erika Cecon, Daniela Fernandois, Nicolas Renault, Caio Fernando Ferreira Coelho, Jan Wenzel, Corentin Bedart, Charlotte Izabelle, Sarah Gallet, Sophie Le Poder, Bernard Klonjkowski, Markus Schwaninger, Vincent Prevot, Julie Dam, Ralf Jockers
Published in: Cell Mol Life Sci, Issue 2022; 79(7), 2022, Page(s) 361, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-022-04390-3

SF1-specific deletion of the energy sensor AMPKγ2 induces obesity

Author(s): Óscar Freire-Agulleiro, Ánxela Estévez-Salguero, Vitor Ferreira, Cassie Lynn Holleman, Julia García-Currás, Ismael González-García, Rubén Nogueiras, Manuel Tena-Sempere, Cristina García-Cáceres, Carlos Diéguez, Miguel López
Published in: Molecular Metabolism, Issue 92, 2025, Page(s) 102091, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.102091

Long-COVID cognitive impairments and reproductive hormone deficits in men may stem from GnRH neuronal death

Author(s): Florent Sauve, Sreekala Nampoothiri, Sophie A. Clarke, Daniela Fernandois, Caio Fernando Ferreira Coêlho, Julie Dewisme, Edouard G. Mills, Gaetan Ternier, Ludovica Cotellessa, Cristina Iglesias-Garcia, Helge Mueller-Fielitz, Thibaud Lebouvier, Romain Perbet, Vincent Florent, Marc Baroncini, Ariane Sharif, June Ereño-Orbea, Maria Mercado-Gómez, Asis Palazon, Virginie Mattot, Florence Pasquier, S
Published in: eBioMedicine, Issue 96, 2024, Page(s) 104784, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2023.104784

Gene therapy targeting the blood-brain barrier improves neurological symptoms in a model of genetic MCT8 deficiency

Author(s): Sivaraj M Sundaram, Adriana Arrulo Pereira, Helge Müller-Fielitz, Hannes Köpke, Meri De Angelis, Timo D Müller, Heike Heuer, Jakob Körbelin, Markus Krohn, Jens Mittag, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Published in: Brain, 2022, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac243

Mitochondrial antiviral signaling protein enhances MASLD progression through the ERK/TNFα/NFκβ pathway

Author(s): Eva Nóvoa, Natália da Silva Lima, Maria J. Gonzalez-Rellan, Maria D.P. Chantada-Vazquez, Joanne Verheij, Amaia Rodriguez, Eva M. Esquinas-Roman, Marcos F. Fondevila, Mirja Koning, Uxia Fernandez, Alba Cabaleiro, Tamara Parracho, Jose Iglesias-Moure, Samuel Seoane, Begoña Porteiro, Adriana Escudero, Ana Senra, Roman Perez-Fernandez, Miguel López, Miguel Fidalgo, Diana Guallar, Maria L. Martinez
Published in: Hepatology, Issue 81, 2025, Page(s) 1535-1552, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1097/hep.0000000000000930

O-GlcNAcylated p53 in the liver modulates hepatic glucose production

Author(s): Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Uxia Fernandez, Amaia Rodríguez, Marta Varela-Rey, Christelle Veyrat-Durebex, Samuel Seoane, Ganeko Bernardo, Fernando Lopitz-Otsoa, David Fernández-Ramos, Jon Bilbao, Cristina Iglesias, Eva Novoa, Cristina Ameneiro, Ana Senra, Daniel Beiroa, Juan Cuñarro, Maria DP Chantada-Vazquez, Maria Garcia-Vence, Susana B. Bravo, Natalia Da Silva Lima, Begoñ
Published in: Nature Communications, Issue 12, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25390-0

Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters

Author(s): Lou Delval, Aline Hantute-Ghesquier, Valentin Sencio, Jean Michel Flaman, Cyril Robil, Fabiola Silva Angulo, Larissa Lipskaia, Ozmen Çobanoğlu, Anne-Sophie Lacoste, Arnaud Machelart, Adeline Danneels, Mathieu Corbin, Lucie Deruyter, Séverine Heumel, Thierry Idziorek, Karin Séron, Florent Sauve, Antonino Bongiovanni, Vincent Prévot, Isabelle Wolowczuk, Sandrine Belouzard, Jean-Michel Saliou, P
Published in: Nature Aging, Issue 3, 2023, Page(s) 829-845, ISSN 2662-8465
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s43587-023-00442-w

Orphan GPR50 Restrains Neurite Outgrowth and Cell Migration by Activating the G<sub>12/13</sub> Protein‐RhoA Pathway in Neural Progenitor Cells and Tanycytes

Author(s): Raise Ahmad, Marine Luka, Anne‐Sophie Journe, Sarah Gallet, Alan Hegron, Marcio Do Cruzeiro, Mark J. Millan, Philippe Delagrange, Bernard Masri, Julie Dam, Vincent Prevot, Ralf Jockers
Published in: Journal of Pineal Research, Issue 77, 2025, ISSN 0742-3098
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jpi.70041

Short regulatory DNA sequences to target brain endothelial cells for gene therapy

Author(s): Hanna Graßhoff, Helge Müller-Fielitz, Godwin K Dogbevia, Jakob Körbelin, Jacqueline Bannach, Carl MG Vahldieck, Kristina Kusche-Vihrog, Olaf Jöhren, Oliver J Müller, Ruben Nogueiras, Vincent Prevot, Markus Schwaninger
Published in: J Cereb Blood Flow Metab, Issue 2022 Jan; 42(1), 2022, Page(s) 104–120, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211039617

Nutritionally induced tanycytic plasticity in the hypothalamus of adult ewes

Author(s): L.D. Prezotto, J.F. Thorson, V. Prevot, D.A. Redmer, A.T. Grazul-Bilska
Published in: Domestic Animal Endocrinology, Issue 72, 2023, Page(s) 106438, ISSN 0739-7240
Publisher: Elsevier BV
DOI: 10.1016/j.domaniend.2020.106438

Hepatic p63 regulates glucose metabolism by repressing SIRT1

Author(s): Maria J Gonzalez-Rellan, Eva Novoa, Natalia da Silva Lima, Amaia Rodriguez, Christelle Veyrat-Durebex, Samuel Seoane, Begoña Porteiro, Marcos F Fondevila, Uxia Fernandez,1 Marta Varela-Rey,6 Ana Senra,1 Cristina Iglesias,1 Adriana Escudero,1 Miguel Fidalgo,1 Diana Guallar,7 Roman Perez-Fernandez,1 Vincent Prevot,8 Markus Schwaninger,9 Miguel López,1,2 Carlos Dieguez,1,2 Roberto Coppari,4,5 Gema
Published in: Gut, Issue 2023 Mar; 72(3), 2023, Page(s) 472–483, ISSN 0017-5749
Publisher: BMJ Publishing Group
DOI: 10.1136/gutjnl-2021-326620

Hypothalamic Structural and Functional Imbalances in Anorexia Nervosa

Author(s): Vincent Florent, Marc Baroncini, Patrice Jissendi-Tchofo, Renaud Lopes, Matthieu Vanhoutte, Sowmyalakshmi Rasika, Jean-Pierre Pruvo, Jean Vignau, Stephane Verdun, Jeanette E. Johansen, Marie Pigeyre, Sebastien G. Bouret, Ida A.K. Nilsson, Vincent Prevot
Published in: Neuroendocrinology, Issue 110, 2025, Page(s) 552-562, ISSN 0028-3835
Publisher: S. Karger AG
DOI: 10.1159/000503147

Diet-Induced Obesity and NASH Impair Disease Recovery in SARS-CoV-2-Infected Golden Hamsters

Author(s): François Briand, Valentin Sencio, Cyril Robil, Séverine Heumel, Lucie Deruyter, Arnaud Machelart, Johanna Barthelemy, Gemma Bogard, Eik Hoffmann, Fabrice Infanti, Oliver Domenig, Audrey Chabrat, Virgile Richard, Vincent Prévot, Ruben Nogueiras, Isabelle Wolowczuk, Florence Pinet, Thierry Sulpice, François Trottein
Published in: Viruses, Issue 14, 2025, Page(s) 2067, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14092067

Small extracellular vesicle targeting of hypothalamic AMPKα1 promotes weight loss in leptin receptor deficient mice

Author(s): Edward Milbank, Nathalia Dragano, Xavi Vidal-Gómez, Verónica Rivas-Limeres, Pablo Garrido-Gil, Mireille Wertheimer, Sylvain Recoquillon, María P. Pata, José Luis Labandeira-Garcia, Carlos Diéguez, Rubén Nogueiras, M. Carmen Martínez, Ramaroson Andriantsitohaina, Miguel López
Published in: Metabolism, Issue 139, 2024, Page(s) 155350, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2022.155350

Orally Induced Hyperthyroidism Regulates Hypothalamic AMP-Activated Protein Kinase

Author(s): Valentina Capelli, Carmen Grijota-Martínez, Nathalia R. V. Dragano, Eval Rial-Pensado, Johan Fernø, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, Miguel López
Published in: Nutrients, Issue 13, 2024, Page(s) 4204, ISSN 2072-6643
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/nu13124204

Tanycytic transcytosis inhibition disrupts energy balance, glucose homeostasis and cognitive function in male mice

Author(s): Manon Duquenne, Eleonora Deligia, Cintia Folgueira, Cyril Bourouh, Emilie Caron, Frank Pfrieger, Markus Schwaninger, Ruben Nogueiras, Jean-Sébastien Annicotte, Monica Imbernon, Vincent Prévot
Published in: Molecular Metabolism, Issue 87, 2024, Page(s) 101996, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.101996

κ-Opioid Signaling in the Lateral Hypothalamic Area Modulates Nicotine-Induced Negative Energy Balance

Author(s): Patricia Seoane-Collazo, Amparo Romero-Picó, Eva Rial-Pensado, Laura Liñares-Pose, Ánxela Estévez-Salguero, Johan Fernø, Rubén Nogueiras, Carlos Diéguez, Miguel López
Published in: International Journal of Molecular Sciences, Issue 22, 2024, Page(s) 1515, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22041515

Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia

Author(s): Alberto Ouro, Amanda Rodríguez-Díaz, Tania López-González, Daniel Romaus-Sanjurjo, Ánxela Estévez-Salguero, Ramón Iglesias-Rey, Mariña Rodríguez-Arrizabalaga, Paola Fernández-Sanmartín, Mónica Castro-Mosquera, Manuel Debasa-Mouce, Antía Custodia, Marta Aramburu-Núñez, María Muñoz-González, Pablo Aguiar, Ismael González-García, Marc Schneeberger, Rubén Nogueiras, Carlos Diégue
Published in: Metabolism, Issue 167, 2025, Page(s) 156160, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2025.156160

Estrogen receptor-α signaling in tanycytes lies at the crossroads of fertility and metabolism

Author(s): Daniela Fernandois, Mariam Rusidzé, Helge Mueller-Fielitz, Florent Sauve, Eleonora Deligia, Mauro S.B. Silva, Florence Evrard, Aurelio Franco-García, Daniele Mazur, Ines Martinez-Corral, Nathalie Jouy, S. Rasika, Claude-Alain Maurage, Paolo Giacobini, Ruben Nogueiras, Benedicte Dehouck, Markus Schwaninger, Francoise Lenfant, Vincent Prevot
Published in: Metabolism, Issue 158, 2024, Page(s) 155976, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2024.155976

O-GlcNAcylation: A Sweet Hub in the Regulation of Glucose Metabolism in Health and Disease

Author(s): Maria J. Gonzalez-Rellan, Marcos F. Fondevila, Carlos Dieguez, Ruben Nogueiras
Published in: Frontiers in Endocrinology, Issue 13, 2022, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2022.873513

Inhibition of hepatic p63 ameliorates steatohepatitis with fibrosis in mice

Author(s): Marcos F. Fondevila, Eva Novoa, Uxia Fernandez, Valentina Dorta, Tamara Parracho, Henriette Kreimeyer, Maria Garcia-Vence, Maria P. Chantada-Vazquez, Susana B. Bravo, Begoña Porteiro, Alba Cabaleiro, Mijra Koning, Ana Senra, Yara Souto, Joanne Verheij, Diana Guallar, Miguel Fidalgo, Abraham S. Meijnikman, Natalia da Silva Lima, Carlos Dieguez, Maria J. Gonzalez-Rellan, Ruben Nogueiras
Published in: Molecular Metabolism, Issue 85, 2024, Page(s) 101962, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2024.101962

Cerebral angiogenesis ameliorates pathological disorders in Nemo -deficient mice with small-vessel disease

Author(s): Yun Jiang, Kristin Müller, Mahtab A. Khan, Julian C. Assmann, Josephine Lampe, Knut Kilau, Marius Richter, Maximilian Kleint, Dirk A Ridder, Norbert Hübner, Marc Schmidt-Supprian, Jan Wenzel, Markus Schwaninger
Published in: Journal of Cerebral Blood Flow & Metabolism, Issue 41/2, 2021, Page(s) 219-235, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x20910522

Glial endozepines and energy balance: Old peptides with new tricks

Author(s): Bruno Lebrun, Manon Barbot, Marie‐Christine Tonon, Vincent Prévot, Jérôme Leprince, Jean‐Denis Troadec
Published in: Glia, Issue 69, 2023, Page(s) 1079-1093, ISSN 0894-1491
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/glia.23927

The spike of SARS-CoV-2 promotes metabolic rewiring in hepatocytes

Author(s): Maria Mercado-Gómez, Endika Prieto-Fernández, Naroa Goikoetxea-Usandizaga, Laura Vila-Vecilla, Mikel Azkargorta, Miren Bravo, Marina Serrano-Maciá, Leire Egia-Mendikute, Rubén Rodríguez-Agudo, Sofia Lachiondo-Ortega, So Young Lee, Alvaro Eguileor Giné, Clàudia Gil-Pitarch, Irene González-Recio, Jorge Simón, Petar Petrov, Ramiro Jover, Luis Alfonso Martínez-Cruz, June Ereño-Orbea, Teresa
Published in: Communications Biology, Issue 5, 2022, ISSN 2399-3642
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42003-022-03789-9

Glial Endozepines Reverse High-Fat Diet-Induced Obesity by Enhancing Hypothalamic Response to Peripheral Leptin

Author(s): Florent Guillebaud, Manon Duquenne, Mehdi Djelloul, Clément Pierre, Kevin Poirot, Guenièvre Roussel, Seddik Riad, Damien Lanfray, Fabrice Morin, André Jean, Marie-Christine Tonon, Stéphanie Gaigé, Bruno Lebrun, Michel Dallaporta, Jérôme Leprince, Vincent Prevot, Jean-Denis Troadec
Published in: Molecular Neurobiology, Issue 57, 2021, Page(s) 3307-3333, ISSN 0893-7648
Publisher: Humana Press, Inc.
DOI: 10.1007/s12035-020-01944-z

Brain JNK and metabolic disease

Author(s): Rubén Nogueiras, Guadalupe Sabio
Published in: Diabetologia, Issue 64/2, 2021, Page(s) 265-274, ISSN 0012-186X
Publisher: Springer Verlag
DOI: 10.1007/s00125-020-05327-w

Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function

Author(s): Manon Duquenne, Cintia Folgueira, Cyril Bourouh, Marion Millet, Anisia Silva, Jérôme Clasadonte, Monica Imbernon, Daniela Fernandois, Ines Martinez-Corral, Soumya Kusumakshi, Emilie Caron, S. Rasika, Eleonora Deliglia, Nathalie Jouy, Asturo Oishi, Massimiliano Mazzone, Eric Trinquet, Jan Tavernier, Young-Bum Kim, Stéphane Ory, Ralf Jockers, Markus Schwaninger, Ulrich Boehm, Ruben Nogueiras, Jea
Published in: Nature Metabolism, 2021, ISSN 2522-5812
Publisher: Nature Portfolio
DOI: 10.1038/s42255-021-00432-5

Cell proliferation and glial cell marker expression in the wall of the third ventricle in the tuberal region of the male mouse hypothalamus during postnatal development

Author(s): Adrian Coutteau‐Robles, Vincent Prevot, Ariane Sharif
Published in: Journal of Neuroendocrinology, Issue 35, 2023, Page(s) 35(3):e13239, ISSN 0953-8194
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jne.13239

Hepatocyte-specific O-GlcNAc transferase downregulation ameliorates nonalcoholic steatohepatitis by improving mitochondrial function

Author(s): Maria J. Gonzalez-Rellan, Tamara Parracho, Violeta Heras, Amaia Rodriguez, Marcos F. Fondevila, Eva Novoa, Natalia Lima, Marta Varela-Rey, Ana Senra, Maria D.P. Chantada-Vazquez, Cristina Ameneiro, Ganeko Bernardo, David Fernandez-Ramos, Fernando Lopitz-Otsoa, Jon Bilbao, Diana Guallar, Miguel Fidalgo, Susana Bravo, Carlos Dieguez, Maria L. Martinez-Chantar, Oscar Millet, Jose M. Mato, Markus Schw
Published in: Molecular Metabolism, Issue 75, 2023, Page(s) 101776, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101776

Novel insights into minipuberty and <scp>GnRH</scp>: Implications on neurodevelopment, cognition, and <scp>COVID</scp>‐19 therapeutics

Author(s): Konstantina Chachlaki, Kevin Le Duc, Laurent Storme, Vincent Prevot
Published in: Journal of Neuroendocrinology, Issue 36, 2024, ISSN 0953-8194
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jne.13387

Glial control of neuronal function

Author(s): Vincent Prevot
Published in: Nature Reviews Endocrinology, Issue 18, 2022, Page(s) 195-195, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-022-00640-3

Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters

Author(s): Valentin Sencio, Arnaud Machelart, Cyril Robil, Nicolas Benech, Eik Hoffmann, Chloé Galbert, Lucie Deryuter, Séverine Heumel, Aline Hantute-Ghesquier, Anne Flourens, Priscille Brodin, Fabrice Infanti, Virgile Richard, Jean Dubuisson, Corinne Grangette, Thierry Sulpice, Isabelle Wolowczuk, Florence Pinet, Vincent Prévot, Sandrine Belouzard, François Briand, Martine Duterque-Coquillaud, Harry So
Published in: Gut Microbes, Issue 14, 2025, Page(s) 14(1):2018900, ISSN 1949-0976
Publisher: Landes Bioscience
DOI: 10.1080/19490976.2021.2018900

BMP8 and activated brown adipose tissue in human newborns

Author(s): Adela Urisarri, Ismael González-García, Ánxela Estévez-Salguero, María P. Pata, Edward Milbank, Noemi López, Natalia Mandiá, Carmen Grijota-Martinez, Carlos A. Salgado, Rubén Nogueiras, Carlos Diéguez, Francesc Villarroya, José-Manuel Fernández-Real, María L. Couce, Miguel López
Published in: Nature Communications, Issue 12, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-25456-z

Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons.

Author(s): Tori Lhomme; Jerome Clasadonte; Monica Imbernon; Daniela Fernandois; Florent Sauve; Emilie Caron; Natália da Silva Lima; Violeta Heras; Ines Martinez-Corral; Helge Mueller-Fielitz; Sowmyalakshmi Rasika; Markus Schwaninger; Rubén Nogueiras; Vincent Prevot
Published in: J Clin Invest, Issue 8, 2021, ISSN 0021-9738
Publisher: American Society for Clinical Investigation
DOI: 10.1172/jci140521

Angiocrine polyamine production regulates adiposity

Author(s): Erika Monelli, Pilar Villacampa, Amaia Zabala-Letona, Anabel Martinez-Romero, Judith Llena, Daniel Beiroa, Leonor Gouveia, Iñigo Chivite, Sebastián Zagmutt, Pau Gama-Perez, Oscar Osorio-Conles, Laia Muixi, Ainara Martinez-Gonzalez, Sandra D. Castillo, Natalia Martín-Martín, Pau Castel, Lorea Valcarcel-Jimenez, Irene Garcia-Gonzalez, Josep A. Villena, Sonia Fernandez-Ruiz, Dolors Serra, Laura H
Published in: Nature Metabolism, Issue 4, 2022, Page(s) 327-343, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-022-00544-6

NF-κB signaling in tanycytes mediates inflammation-induced anorexia

Author(s): Mareike Böttcher, Helge Müller-Fielitz, Sivaraj M. Sundaram, Sarah Gallet, Vanessa Neve, Kiseko Shionoya, Adriano Zager, Ning Quan, Xiaoyu Liu, Ruth Schmidt-Ullrich, Ronny Haenold, Jan Wenzel, Anders Blomqvist, David Engblom, Vincent Prevot, Markus Schwaninger
Published in: Molecular Metabolism, Issue 39, 2020, Page(s) 101022, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2020.101022

Temperature modulates systemic and central actions of thyroid hormones on BAT thermogenesis

Author(s): Eva Rial-Pensado, Verónica Rivas-Limeres, Carmen Grijota-Martínez, Amanda Rodríguez-Díaz, Valentina Capelli, Olga Barca-Mayo, Rubén Nogueiras, Jens Mittag, Carlos Diéguez, Miguel López
Published in: Frontiers in Physiology, Issue 13, 2022, ISSN 1664-042X
Publisher: Frontiers Research Foundation
DOI: 10.3389/fphys.2022.1017381

Acute changes in systemic glycemia gate access and action of GLP-1R agonist on brain structures controlling energy homeostasis.

Author(s): Wineke Bakker; Monica Imbernon; Casper Gravesen Salinas; Daniela Herrera Moro Chao; Rim Hassouna; Chloe Morel; Claire Martin; Caroline Leger; Raphael G.P. Denis; Julien Castel; Andreas Peter; Martin Heni; Walter Maetzler; Heidi Solvang Nielsen; Manon Duquenne; Markus Schwaninger; Sofia Lundh; Wouter Frederic Johan Hogendorf; Giuseppe Gangarossa; Anna Secher; Jacob Hecksher-Sørensen; Thomas Åskov
Published in: Cell Rep. 41:111698 (2022), Issue 7, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111698

The Role of Tanycytes in the Hypothalamus-Pituitary-Thyroid Axis and the Possibilities for Their Genetic Manipulation

Author(s): Helge Müller-Fielitz, Markus Schwaninger
Published in: Experimental and Clinical Endocrinology & Diabetes, Issue 128/06/07, 2020, Page(s) 388-394, ISSN 0947-7349
Publisher: Johann Ambrosius Barth
DOI: 10.1055/a-1065-1855

The SARS-CoV-2 main protease M-pro causes microvascular brain pathology by cleaving NEMO in brain endothelial cells

Author(s): Josephine Lampe; Jan Wenzel; Helge Müller-Fielitz; Kristin Müller; Raphael Schuster; Linlin Zhang; Marietta Zille; Markus Krohn; Ümit Özorhan; Yun Jiang; Vanessa Neve; Anke Fähnrich; Fabian Ott; Sonja Binder; Hauke Busch; Ludovic Collin; Roberto Villasenor; Olaf Jöhren; Hermann Altmeppen; Manolis Pasparakis; Ruben Nogueiras; Vincent Prevot; Rolf Hilgenfeld; Markus Glatzel; Markus Schwaninger
Published in: Nature neuroscience, Issue 10, 2021, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.21203/rs.3.rs-86988/v1

Hypothalamic free fatty acid receptor-1 regulates whole-body energy balance

Author(s): Nathalia R.V. Dragano, Edward Milbank, Roberta Haddad-Tóvolli, Pablo Garrido-Gil, Eva Nóvoa, Marcos F. Fondevilla, Valentina Capelli, Ariane Maria Zanesco, Carina Solon, Joseane Morari, Leticia Pires, Ánxela Estevez-Salguero, Daniel Beiroa, Ismael González-García, Olga Barca-Mayo, Carlos Diéguez, Ruben Nogueiras, José L. Labandeira-García, Elisabeth Rexen Ulven, Trond Ulven, Marc Claret, L
Published in: Molecular Metabolism, Issue 79, 2024, Page(s) 101840, ISSN 2212-8778
Publisher: Elsevier GmbH
DOI: 10.1016/j.molmet.2023.101840

Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?

Author(s): Elvira S. Sandin; Julica Folberth; Helge Müller-Fielitz; Claus U. Pietrzik; Elisabeth Herold; Thomas E. Willnow; Paul T. Pfluger; Ruben Nogueiras; Vincent Prevot; Thomas Krey; Markus Schwaninger
Published in: reponame:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela, Issue 4, 2021, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms22094998

The L‐α‐lysophosphatidylinositol/GPR55 system induces the development of non‐alcoholic steatosis and steatohepatitis

Author(s): Marcos F. Fondevila, Uxia Fernandez, Maria J. Gonzalez‐Rellan, Natalia Da Silva Lima, Xabier Buque, Agueda Gonzalez‐Rodriguez, Cristina Alonso, Marta Iruarrizaga‐Lejarreta, Teresa C. Delgado, Marta Varela‐Rey, Ana Senra, Vera Garcia‐Outeiral, Eva Novoa, Cristina Iglesias, Begoña Porteiro, Daniel Beiroa, Cintia Folgueira, Marta Tojo, Jorge L. Torres, Lourdes Hernández‐Cosido, Óscar B
Published in: Hepatology, 2020, ISSN 0270-9139
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/hep.31290

Nicotine’ actions on energy balance: Friend or foe?

Author(s): Patricia Seoane-Collazo, Carlos Diéguez, Rubén Nogueiras, Kamal Rahmouni, José Manuel Fernández-Real, Miguel López
Published in: Pharmacology & Therapeutics, 2020, Page(s) 107693, ISSN 0163-7258
Publisher: Pergamon Press
DOI: 10.1016/j.pharmthera.2020.107693

Regulation of Thyroid Hormone Gatekeepers by Thyrotropin in Tanycytes

Author(s): Akila Chandrasekar, Paula Marie Schmidtlein, Vanessa Neve, Manon Rivagorda, Frauke Spiecker, Karine Gauthier, Vincent Prevot, Markus Schwaninger, Helge Müller-Fielitz
Published in: Thyroid®, Issue 34, 2024, Page(s) 261-273, ISSN 1050-7256
Publisher: Mary Ann Liebert Inc.
DOI: 10.1089/thy.2023.0375

Impaired endothelium-mediated cerebrovascular reactivity promotes anxiety and respiration disorders in mice

Author(s): Jan Wenzel, Cathrin E. Hansen, Carla Bettoni, Miriam A. Vogt, Beate Lembrich, Rentsenkhand Natsagdorj, Gianna Huber, Josefine Brands, Kjestine Schmidt, Julian C. Assmann, Ines Stölting, Kathrin Saar, Jan Sedlacik, Jens Fiehler, Peter Ludewig, Michael Wegmann, Nina Feller, Marius Richter, Helge Müller-Fielitz, Thomas Walther, Gabriele M. König, Evi Kostenis, Walter Raasch, Norbert Hübner, Peter
Published in: Proceedings of the National Academy of Sciences, Issue 117/3, 2020, Page(s) 1753-1761, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.1907467117

Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism

Author(s): María J. Gonzalez-Rellan, Uxía Fernández, Tamara Parracho, Eva Novoa, Marcos F. Fondevila, Natalia da Silva Lima, Lucía Ramos, Amaia Rodríguez, Marina Serrano-Maciá, Gonzalo Perez-Mejias, Pilar Chantada-Vazquez, Cristina Riobello, Christelle Veyrat-Durebex, Sulay Tovar, Roberto Coppari, Ashwin Woodhoo, Markus Schwaninger, Vincent Prevot, Teresa C. Delgado, Miguel Lopez, Antonio Diaz-Quintana
Published in: Cell Metabolism, Issue 35, 2023, Page(s) 1630-1645.e5, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2023.07.003

Hypothalamic bile acid-TGR5 signaling protects from obesity

Author(s): Ashley Castellanos-Jankiewicz, Omar Guzmán-Quevedo, Valérie S. Fénelon, Philippe Zizzari, Carmelo Quarta, Luigi Bellocchio, Anne Tailleux, Julie Charton, Daniela Fernandois, Marcus Henricsson, Catherine Piveteau, Vincent Simon, Camille Allard, Sandrine Quemener, Valentine Guinot, Nathalie Hennuyer, Alessia Perino, Alexia Duveau, Marlène Maitre, Thierry Leste-Lasserre, Samantha Clark, Nathalie
Published in: Cell Metabolism, 2021, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2021.04.009

Seeing through the fog: a neuroendocrine explanation for post-COVID cognitive deficits

Author(s): S. Rasika, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Published in: Nature Reviews Endocrinology, Issue 20, 2024, Page(s) 189-190, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-024-00955-3

The hypothalamic–pituitary–gonadal axis and the enigma of Alzheimer disease sex differences

Author(s): Florent Sauvé, Loïc Kacimi, Vincent Prévot
Published in: Nature Reviews Endocrinology, Issue 20, 2024, Page(s) 317-318, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-024-00981-1

Kappa-Opioid Receptor Blockade Ameliorates Obesity Caused by Estrogen Withdrawal via Promotion of Energy Expenditure through mTOR Pathway

Author(s): Amparo Romero-Picó, Marta G. Novelle, Omar Al-Massadi, Daniel Beiroa, Marta Tojo, Violeta Heras, Francisco Ruiz-Pino, Ana Senra, Miguel López, Clemence Blouet, Manuel Tena-Sempere, Rubén Nogueiras, Carlos Diéguez
Published in: International Journal of Molecular Sciences, Issue 23, 2024, Page(s) 3118, ISSN 1422-0067
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/ijms23063118

Endogenous THBD (Thrombomodulin) Mediates Angiogenesis in the Ischemic Brain

Author(s): Jan Wenzel, Dimitrios Spyropoulos, Julian Christopher Assmann, Mahtab Ahmad Khan, Ines Stölting, Beate Lembrich, Sara Kreißig, Dirk Andreas Ridder, Berend Isermann, Markus Schwaninger
Published in: Arteriosclerosis, Thrombosis, and Vascular Biology, 2020, ISSN 1079-5642
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/atvbaha.120.315061

Absence of Both Thyroid Hormone Transporters MCT8 and OATP1C1 Impairs Neural Stem Cell Fate in the Adult Mouse Subventricular Zone

Author(s): Cristina Luongo, Lucile Butruille, Anthony Sébillot, Karine Le Blay, Markus Schwaninger, Heike Heuer, Barbara A. Demeneix, Sylvie Remaud
Published in: Stem Cell Reports, Issue 16, 2022, Page(s) 337-353, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.12.009

COVID-19 could worsen cerebral amyloid angiopathy

Author(s): Julie Dewisme, Thibaud Lebouvier, Quentin Vannod-Michel, null null, Vincent Prevot, Claude-Alain Maurage
Published in: Journal of Neuropathology & Experimental Neurology, Issue 82, 2024, Page(s) 814-817, ISSN 0022-3069
Publisher: American Association of Neuropathologists, Inc.
DOI: 10.1093/jnen/nlad049

The reactive pyruvate metabolite dimethylglyoxal mediates neurological consequences of diabetes

Author(s): Sina Rhein, Riccardo Costalunga, Julica Inderhees, Tammo Gürtzgen, Teresa Christina Faupel, Zaib Shaheryar, Adriana Arrulo Pereira, Alaa Othman, Kimberly Begemann, Sonja Binder, Ines Stölting, Valentina Dorta, Peter P. Nawroth, Thomas Fleming, Konrad Oexle, Vincent Prevot, Ruben Nogueiras, Svenja Meyhöfer, Sebastian M. Meyhöfer, Markus Schwaninger
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-50089-3

Sirt3 in POMC neurons controls energy balance in a sex- and diet-dependent manner

Author(s): Mar Quiñones, René Hernández-Bautista, Daniel Beiroa, Violeta Heras, Francisco L. Torres-Leal, Brian Y.H. Lam, Ana Senra, Johan Fernø, Alicia García Gómez-Valadés, Markus Schwaninger, Vincent Prevot, Giles Yeo, Marc Claret, Miguel López, Carlos Diéguez, Omar Al-Massadi, Ruben Nogueiras
Published in: Redox Biology, Issue 41, 2021, Page(s) 101945, ISSN 2213-2317
Publisher: Elsevier BV
DOI: 10.1016/j.redox.2021.101945

Distinct Actions of the Thyroid Hormone Transporters Mct8 and Oatp1c1 in Murine Adult Hippocampal Neurogenesis

Author(s): Steffen Mayerl, Andrea Alcaide Martin, Reinhard Bauer, Markus Schwaninger, Heike Heuer, Charles ffrench-Constant
Published in: Cells, Issue 11, 2025, Page(s) 524, ISSN 2073-4409
Publisher: MDPI AG
DOI: 10.3390/cells11030524

Bitter taste cells in the ventricular walls of the murine brain regulate glucose homeostasis

Author(s): Qiang Yu, Igor Gamayun, Philipp Wartenberg, Qian Zhang, Sen Qiao, Soumya Kusumakshi, Sarah Candlish, Viktoria Götz, Shuping Wen, Debajyoti Das, Amanda Wyatt, Vanessa Wahl, Fabien Ectors, Kathrin Kattler, Daniela Yildiz, Vincent Prevot, Markus Schwaninger, Gaetan Ternier, Paolo Giacobini Philippe Ciofi, Timo D Müller, Ulrich Boehm
Published in: Nat Commun ., Issue 2023 Mar 22;14(1):1588, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-37099-3

Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work

Author(s): Greg M. Anderson, Jennifer W. Hill, Ursula B. Kaiser, Victor M. Navarro, Ken K. Ong, John R. B. Perry, Vincent Prevot, Manuel Tena-Sempere, Carol F. Elias
Published in: Nature Reviews Endocrinology, Issue 20, 2024, Page(s) 111-123, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-023-00919-z

MCH Neurons Regulate Permeability of the Median Eminence Barrier

Author(s): Hong Jiang, Sarah Gallet, Paul Klemm, Pia Scholl, Kat Folz-Donahue, Janine Altmüller, Jens Alber, Christian Heilinger, Christian Kukat, Anne Loyens, Helge Müller-Fielitz, Sivaraj Sundaram, Markus Schwaninger, Vincent Prevot, Jens C. Brüning
Published in: Neuron, Issue 107/2, 2020, Page(s) 306-319.e9, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2020.04.020

Central nicotine induces browning through hypothalamic κ opioid receptor

Author(s): Patricia Seoane-Collazo, Laura Liñares-Pose, Eva Rial-Pensado, Amparo Romero-Picó, José María Moreno-Navarrete, Noelia Martínez-Sánchez, Pablo Garrido-Gil, Ramón Iglesias-Rey, Donald A. Morgan, Naoki Tomasini, Samuel Andrew Malone, Ana Senra, Cintia Folgueira, Gema Medina-Gomez, Tomás Sobrino, José L. Labandeira-García, Rubén Nogueiras, Ana I. Domingos, José-Manuel Fernández-Real, Kam
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12004-z

Nesfatin-1 decreases the motivational and rewarding value of food

Author(s): Riccardo Dore, Regina Krotenko, Jan Philipp Reising, Luca Murru, Sivaraj Mohana Sundaram, Alessandro Di Spiezio, Helge Müller-Fielitz, Markus Schwaninger, Olaf Jöhren, Jens Mittag, Maria Passafaro, Marya Shanabrough, Tamas L. Horvath, Carla Schulz, Hendrik Lehnert
Published in: Neuropsychopharmacology, Issue 45, 2021, Page(s) 1645-1655, ISSN 0893-133X
Publisher: Nature Publishing Group
DOI: 10.1038/s41386-020-0682-3

Parvocellular Oxytocin Neurons and Autism Spectrum Disorders

Author(s): Sivaraj Mohana Sundaram, Markus Schwaninger
Published in: Trends in Endocrinology and Metabolism, 2021, Page(s) 195-197, ISSN 1043-2760
Publisher: Elsevier BV
DOI: 10.1016/j.tem.2021.01.004

A functional cerebral endothelium is necessary to protect against cognitive decline

Author(s): Lianne J Trigiani, Miled Bourourou, María Lacalle-Aurioles, Clotilde Lecrux, Amy Hynes, Shoshana Spring, Darren J Fernandes, John G Sled, Frédéric Lesage, Markus Schwaninger, Edith Hamel
Published in: Journal of Cerebral Blood Flow & Metabolism, Issue 42, 2025, Page(s) 74-89, ISSN 0271-678X
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1177/0271678x211045438

Multifaceted actions of melanin-concentrating hormone on mammalian energy homeostasis

Author(s): Omar Al-Massadi, Carlos Dieguez, Marc Schneeberger, Miguel López, Markus Schwaninger, Vincent Prevot, Ruben Nogueiras
Published in: Nature Reviews Endocrinology, Issue 17, 2022, Page(s) 745-755, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-021-00559-1

Activity-Based Anorexia Induces Browning of Adipose Tissue Independent of Hypothalamic AMPK

Author(s): Angela Fraga, Eva Rial-Pensado, Rubén Nogueiras, Johan Fernø, Carlos Diéguez, Emilio Gutierrez, Miguel López
Published in: Frontiers in Endocrinology, Issue 12, 2021, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2021.669980

Diet modulates the therapeutic effects of dimethyl fumarate mediated by the immunometabolic neutrophil receptor HCAR

Author(s): Joanna Kosinska, Julian C Assmann, Julica Inderhees, Helge Müller-Fielitz, Kristian Händler, Sven Geisler, Axel Künstner, Hauke Busch, Anna Worthmann, Joerg Heeren, Christian Sadik, Matthias Gunzer, Vincent Prévot, Ruben Nogueiras, Misa Hirose, Malte Spielmann, Stefan Offermanns, Nina Wettschureck, Markus Schwaninger
Published in: eLife, Issue 14, 2025, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.98970

Tanycytes control hypothalamic liraglutide uptake and its anti-obesity actions

Author(s): Monica Imbernon, Chiara Saponaro, Hans Christian Cederberg Helms, Manon Duquenne, Daniela Fernandois, Eleonora Deligia, Raphael G.P. Denis, Daniela Herrera Moro Chao, Sowmyalakshmi Rasika, Bart Staels, François Pattou, Frank W. Pfrieger, Birger Brodin, Serge Luquet, Caroline Bonner, Vincent Prevot
Published in: Cell Metabolism, Issue 34, 2024, Page(s) 1054-1063.e7, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2022.06.002

GLP-1 and GIP agonism has no direct actions in human hepatocytes or hepatic stellate cells

Author(s): Natália da Silva Lima, Alba Cabaleiro, Eva Novoa, Cristina Riobello, Patrick J. Knerr, Yantao He, Eva M. Esquinas-Román, Ismael González-García, Vincent Prevot, Markus Schwaninger, Carlos Dieguez, Miguel López, Timo D. Müller, Marta Varela-Rey, Jonathan D. Douros, Ruben Nogueiras
Published in: Cellular and Molecular Life Sciences, Issue 81, 2024, ISSN 1420-682X
Publisher: Birkhauser Verlag
DOI: 10.1007/s00018-024-05507-6

MCH Regulates SIRT1/FoxO1 and Reduces POMC Neuronal Activity to Induce Hyperphagia, Adiposity, and Glucose Intolerance

Author(s): Omar Al-Massadi, Mar Quiñones, Jerome Clasadonte, René Hernandez-Bautista, Amparo Romero-Picó, Cintia Folgueira, Donald A. Morgan, Imre Kalló, Violeta Heras, Ana Senra, Samuel C. Funderburk, Michael J. Krashes, Yara Souto, Miguel Fidalgo, Serge Luquet, Melissa J. Chee, Monica Imbernon, Daniel Beiroa, Lucía García-Caballero, Rosalia Gallego, Brian Y.H. Lam, Giles Yeo, Miguel Lopez, Zsolt Lipo
Published in: Diabetes, Issue 68/12, 2019, Page(s) 2210-2222, ISSN 0012-1797
Publisher: American Diabetes Association
DOI: 10.2337/db19-0029

A plastic aggrecan barrier modulated by peripheral energy state gates metabolic signal access to arcuate neurons

Author(s): Laura Kuczynski-Noyau, Sixtine Karmann, Paolo Alberton, Ines Martinez-Corral, Sreekala Nampoothiri, Florent Sauvé, Tori Lhomme, Carmelo Quarta, Suneel S. Apte, Sébastien Bouret, Attila Aszodi, Sowmyalakshmi Rasika, Philippe Ciofi, Julie Dam, Vincent Prévot, Virginie Mattot
Published in: Nature Communications, Issue 15, 2024, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-024-50798-9

Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21

Author(s): Veronica Pena-Leon, Cintia Folgueira, Silvia Barja-Fernández, Raquel Pérez-Lois, Natália Da Silva Lima, Marion Martin, Violeta Heras, Sara Martinez-Martinez, Paola Valero, Cristina Iglesias, Mannon Duquenne, Omar Al-Massadi, Daniel Beiroa, Yara Souto, Miguel Fidalgo, Rasika Sowmyalakshmi, Diana Guallar, Juan Cunarro, Cecilia Castelao, Ana Senra, Patricia González-Saenz, Rocío Vázquez-Cobela,
Published in: Nat Metab ., Issue 2022 Jul;4(7), 2022, Page(s) 901-917, ISSN 2522-5812
Publisher: Nature Portfolio
DOI: 10.1038/s42255-022-00602-z

Circulating ghrelin crosses the blood-cerebrospinal fluid barrier via growth hormone secretagogue receptor dependent and independent mechanisms

Author(s): Maia Uriarte, Pablo N. De Francesco, Gimena Fernández, Daniel Castrogiovanni, Micaela D'Arcangelo, Mónica Imbernon, Sonia Cantel, Severine Denoyelle, Jean-Alain Fehrentz, Jeppe Praetorius, Vincent Prevot, Mario Perello
Published in: Molecular and Cellular Endocrinology, Issue 538, 2023, Page(s) 111449, ISSN 0303-7207
Publisher: Elsevier BV
DOI: 10.1016/j.mce.2021.111449

Hypothalamic dopamine signalling regulates brown fat thermogenesis

Author(s): Cintia Folgueira, Daniel Beiroa, Begoña Porteiro, Manon Duquenne, Emma Puighermanal, Marcos F. Fondevila, Silvia Barja-Fernández, Rosalia Gallego, René Hernández-Bautista, Cecilia Castelao, Ana Senra, Patricia Seoane-Collazo, Noemi Gómez-Lado, Pablo Aguiar, Diana Guallar, Miguel Fidalgo, Amparo Romero-Pico, Roger Adan, Clemence Blouet, Jose Luís Labandeira-García, Françoise Jeanrenaud, Imr
Published in: Nature Metabolism, Issue 1/8, 2019, Page(s) 811-829, ISSN 2522-5812
Publisher: Nature
DOI: 10.1038/s42255-019-0099-7

PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism

Author(s): Aileen A. Ren, Daniel A. Snellings, Yourong S. Su, Courtney C. Hong, Marco Castro, Alan T. Tang, Matthew R. Detter, Nicholas Hobson, Romuald Girard, Sharbel Romanos, Rhonda Lightle, Thomas Moore, Robert Shenkar, Christian Benavides, M. Makenzie Beaman, Helge Müller-Fielitz, Mei Chen, Patricia Mericko, Jisheng Yang, Derek C. Sung, Michael T. Lawton, J. Michael Ruppert, Markus Schwaninger, Jakob K
Published in: Nature, Issue 594, 2023, Page(s) 271-276, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-03562-8

p63 controls metabolic activation of hepatic stellate cells and fibrosis via an HER2-ACC1 pathway

Author(s): Marcos F. Fondevila, Eva Novoa, Maria J. Gonzalez-Rellan, Uxia Fernandez, Violeta Heras, Begoña Porteiro, Tamara Parracho, Valentina Dorta, Cristina Riobello, Natalia da Silva Lima, Samuel Seoane, Maria Garcia-Vence, Maria P. Chantada-Vazquez, Susana B. Bravo, Ana Senra, Magdalena Leiva, Miguel Marcos, Guadalupe Sabio, Roman Perez-Fernandez, Carlos Dieguez, Vincent Prevot, Markus Schwaninger, Ash
Published in: Cell Reports Medicine, Issue 5, 2024, Page(s) 101401, ISSN 2666-3791
Publisher: Elsevier BV
DOI: 10.1016/j.xcrm.2024.101401

The polygamous GnRH neuron: Astrocytic and tanycytic communication with a neuroendocrine neuronal population

Author(s): Vincent Prevot, Ariane Sharif
Published in: Journal of Neuroendocrinology, Issue 34, 2023, ISSN 0953-8194
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/jne.13104

Selective Depletion of Adult GFAP-Expressing Tanycytes Leads to Hypogonadotropic Hypogonadism in Males

Author(s): Lucile Butruille, Martine Batailler, Marie-Line Cateau, Ariane Sharif, Valérie Leysen, Vincent Prévot, Pascal Vaudin, Delphine Pillon, Martine Migaud
Published in: Frontiers in Endocrinology, Issue 13, 2022, ISSN 1664-2392
Publisher: Frontiers Media SA
DOI: 10.3389/fendo.2022.869019

Preventing and correcting polycystic ovary syndrome by targeting anti-Müllerian hormone signaling in minipuberty and adulthood in mice

Author(s): Ludovica Cotellessa, Veronica Sobrino, Mauro S.B. Silva, Maxime Delit, Hélène Maitre, Emilie Caron, Gaëtan Ternier, Natalia da Silva Lima, Tori Lhomme, Frank Giton, Andrea Sorrentino, Laura Carraresi, Giovanna Di Nardo, Ruben Nogueiras, Manuel Tena-Sempere, Vincent Prevot, Paolo Giacobini
Published in: Cell Metabolism, Issue Apr 8:S1550-4131(25)00116-0, 2025, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2025.03.013

Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity

Author(s): Marta Porniece Kumar, Anna Lena Cremer, Paul Klemm, Lukas Steuernagel, Sivaraj Sundaram, Alexander Jais, A. Christine Hausen, Jenkang Tao, Anna Secher, Thomas Åskov Pedersen, Markus Schwaninger, F. Thomas Wunderlich, Bradford B. Lowell, Heiko Backes, Jens C. Brüning
Published in: Nature Metabolism, Issue 3, 2022, Page(s) 1662-1679, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-021-00499-0

Astrogenesis in the hypothalamus: A life-long process contributing to the development and plasticity of neuroendocrine networks

Author(s): Ariane Sharif, Vincent Prevot
Published in: Frontiers in Neuroendocrinology, Issue 75, 2024, Page(s) 101154, ISSN 0091-3022
Publisher: Academic Press
DOI: 10.1016/j.yfrne.2024.101154

Rapid modulation of gut microbiota composition by hypothalamic circuits in mice

Author(s): Míriam Toledo, Sara Martínez-Martínez, Matthias Van Hul, Berta Laudo, Elena Eyre, Rudy Pelicaen, Anthony Puel, Jordi Altirriba, Alicia G. Gómez-Valadés, Julica Inderhees, Isabel Moreno-Indias, Macarena Pozo, Iñigo Chivite, Maria Milà-Guasch, Roberta Haddad-Tóvolli, Arnaud Obri, Júlia Fos-Domènech, Iasim Tahiri, Sergio R. Llana, Sara Ramírez, Erika Monelli, Markus Schwaninger, Patrice D.
Published in: Nature Metabolism, Issue Apr 22, 2025, ISSN 2522-5812
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42255-025-01280-3

Serum Metabolites as Potential Markers and Predictors of Depression-like Behavior and Effective Fluoxetine Treatment in Chronically Socially Isolated Rats

Author(s): Dragana Filipović, Julica Inderhees, Alexandra Korda, Predrag Tadić, Markus Schwaninger, Dragoš Inta, Stefan Borgwardt
Published in: Metabolites, Issue 14, 2025, Page(s) 405, ISSN 2218-1989
Publisher: MDPI AG
DOI: 10.3390/metabo14080405

Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis

Author(s): Sreekala Nampoothiri, Ruben Nogueiras, Markus Schwaninger, Vincent Prevot
Published in: Nat Metab ., Issue 2022 Jul;4(7), 2022, Page(s) 813-825, ISSN 2522-5812
Publisher: Nature Portfolio
DOI: 10.1038/s42255-022-00610-z

A brainstem–hypothalamus neuronal circuit reduces feeding upon heat exposure

Author(s): Marco Benevento, Alán Alpár, Anna Gundacker, Leila Afjehi, Kira Balueva, Zsofia Hevesi, János Hanics, Sabah Rehman, Daniela D. Pollak, Gert Lubec, Peer Wulff, Vincent Prevot, Tamas L. Horvath, Tibor Harkany
Published in: Nature, Issue 628, 2024, Page(s) 826-834, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-024-07232-3

Hypothalamic SIRT1-mediated regulation of the hormonal trigger of ovulation and its repression in energy deficit

Author(s): María J. Vazquez, Silvia Daza-Dueñas, Inmaculada Velasco, Francisco Ruiz-Pino, María J. Sanchez-Tapia, María Manfredi-Lozano, Carmen Torres-Granados, Alexia Barroso, Juan Roa, Miguel A. Sánchez-Garrido, Carlos Dieguez, Alejandro Lomniczi, Rubén Nogueiras, Manuel Tena-Sempere
Published in: Metabolism, Issue 164, 2025, Page(s) 156125, ISSN 0026-0495
Publisher: Elsevier BV
DOI: 10.1016/j.metabol.2024.156125

Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism

Author(s): Cristina García-Cáceres, Eglantine Balland, Vincent Prevot, Serge Luquet, Stephen C. Woods, Marco Koch, Tamas L. Horvath, Chun-Xia Yi, Julia A. Chowen, Alexei Verkhratsky, Alfonso Araque, Ingo Bechmann, Matthias H. Tschöp
Published in: Nature Neuroscience, Issue 22, 2023, Page(s) 7-14, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-018-0286-y

Inhibition of carnitine palmitoyltransferase 1A in hepatic stellate cells protects against fibrosis

Author(s): Marcos F. Fondevila, Uxia Fernandez, Violeta Heras, Tamara Parracho, Maria J. Gonzalez-Rellan, Eva Novoa, Begoña Porteiro, Cristina Alonso, Rebeca Mayo, Natalia da Silva Lima, Cristina Iglesias, Aveline A. Filliol, Ana Senra, Teresa C. Delgado, Ashwin Woodhoo, Laura Herrero, Dolors Serra, Vincent Prevot, Markus Schwaninger, Miguel López, Ruben Nogueiras
Published in: J. Hepatol., Issue Volume 77, Issue 1, July 2022, 2022, Page(s) 15-28, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2022.02.003

MECHANISMS IN ENDOCRINOLOGY: The gut–brain axis: regulating energy balance independent of food intake

Author(s): Ruben Nogueiras
Published in: European Journal of Endocrinology, Issue 185, 2023, Page(s) R75-R91, ISSN 0804-4643
Publisher: BioScientifica Ltd.
DOI: 10.1530/eje-21-0277

Bridging brain barriers for gene therapy

Author(s): Markus Schwaninger, Vincent Prevot, Ruben Nogueiras
Published in: Open Access Government, Issue 42, 2024, Page(s) 210-211, ISSN 2516-3817
Publisher: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-042-10410

Feed or breed: Hypothalamic mechanisms linking energy availability to puberty onset

Author(s): Alicia Sicardi, Daniela Fernandois, Vincent Prevot
Published in: Neuron, Issue 113, 2025, Page(s) 968-970, ISSN 0896-6273
Publisher: Cell Press
DOI: 10.1016/j.neuron.2025.03.012

How COVID-19 affects microvessels in the brain

Author(s): Jan Wenzel, Markus Schwaninger
Published in: Brain, 2022, ISSN 0006-8950
Publisher: Oxford University Press
DOI: 10.1093/brain/awac211

Glycemic control: Tanycytes march to the beat of the suprachiasmatic drummer

Author(s): Monica Imbernon, Benedicte Dehouck, Vincent Prevot
Published in: Current Biology, Issue 32, 2024, Page(s) R173-R176, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2022.01.038

The WATCH project: Tanycytes in health and disease

Author(s): Vincent Prevot, Markus Schwaninger, Ruben Nogueiras
Published in: Open Access Government, Issue 37, 2023, Page(s) 132-133, ISSN 2516-3817
Publisher: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-037-10410

Prolonged lactation: Preventing obesity since infancy

Author(s): Vincent Prevot, Markus Schwaninger, Ruben Nogueiras
Published in: Open Access Government, Issue 43, 2024, Page(s) 106-107, ISSN 2516-3817
Publisher: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-043-10410

L’IRM hypothalamique, un nouvel outil diagnostique dans l’anorexie mentale ?

Author(s): Vincent Florent, Marc Baroncini, Vincent Prévot
Published in: médecine/sciences, Issue 36, 2020, Page(s) 115-117, ISSN 0767-0974
Publisher: Editions E D K
DOI: 10.1051/medsci/2020007

Seasonal biology: Tanycytes give the hypothalamus a spring makeover

Author(s): Manon Rivagorda, Vincent Prevot, Markus Schwaninger
Published in: Current Biology, Issue 34, 2025, Page(s) R209-R211, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2024.01.055

Food odour recognition adjusts systemic metabolism to nutrient availability

Author(s): Vincent Prevot, Ruben Nogueiras
Published in: Nature Reviews Endocrinology, Issue 19, 2023, Page(s) 130-131, ISSN 1759-5029
Publisher: Nature Publishing Group
DOI: 10.1038/s41574-022-00801-4

Sowing SARS-CoV-2 to reap neurodegeneration: A hamster study

Author(s): S. Rasika, Daniela Fernandois, Vincent Prévot
Published in: eBioMedicine, Issue 80, 2022, Page(s) 104071, ISSN 2352-3964
Publisher: Elsevier BV
DOI: 10.1016/j.ebiom.2022.104071

Obese patients with NASH have increased hepatic expression of SARS-CoV-2 critical entry points

Author(s): Marcos F. Fondevila, Maria Mercado-Gómez, Amaia Rodríguez, Maria J. Gonzalez-Rellan, Paula Iruzubieta, Víctor Valentí, Javier Escalada, Markus Schwaninger, Vincent Prevot, Carlos Dieguez, Javier Crespo, Gema Frühbeck, Maria L. Martinez- Chantar, Ruben Nogueiras
Published in: Journal of Hepatology, 2020, ISSN 0168-8278
Publisher: Elsevier BV
DOI: 10.1016/j.jhep.2020.09.027

Brain infection by SARS-CoV-2: Lifelong consequences

Author(s): Vincent Prévot
Published in: Open Access Government, Issue 41, 2024, Page(s) 22-23, ISSN 2516-3817
Publisher: Adjacent Digital Politics Ltd
DOI: 10.56367/oag-041-10397

Les neurones produisant l’hormone de mélano-concentration régulent la fenestration des anses vasculaires de l’éminence médiane

Author(s): Alicia Sicardi, Vincent Prévot
Published in: médecine/sciences, Issue 38, 2022, Page(s) 248-251, ISSN 0767-0974
Publisher: Editions E D K
DOI: 10.1051/medsci/2022016

Les neurones produisant la gonadolibérine sculptent leur environnement neuroglial dans la petite enfance

Author(s): Ariane Sharif, Vincent Prévot
Published in: médecine/sciences, Issue 38, 2022, Page(s) 428-430, ISSN 0767-0974
Publisher: Editions E D K
DOI: 10.1051/medsci/2022047

Unveiling the Importance of Tanycytes in the Control of the Dialogue Between the Brain and the Periphery

Author(s): Sreekala Nampoothiri, Manon Duquenne, Vincent Prevot
Published in: Masterclass in Neuroendocrinology, Glial-Neuronal Signaling in Neuroendocrine Systems, Issue Issue 11, pp 255-284, 2023, Page(s) 255-284
Publisher: Springer International Publishing
DOI: 10.1007/978-3-030-62383-8_11

Tanycytes in the infundibular nucleus and median eminence and their role in the blood–brain barrier

Author(s): Vincent Prevot, Ruben Nogueiras, Markus Schwaninger
Published in: Handbook of Clinical Neurology, The Human Hypothalamus - Middle and Posterior Region, Issue 180:253-273, 2022, Page(s) 253-273
Publisher: Elsevier
DOI: 10.1016/b978-0-12-820107-7.00016-1

Gene therapy targeting the blood-brain barrier

Author(s): Jakob Körbelin, Adriana Arrulo, Markus Schwaninger
Published in: Vitamins and Hormones, Blood-Brain Barrier, Issue 126, 2024, Page(s) 191-217
Publisher: Elsevier
DOI: 10.1016/bs.vh.2024.03.001

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