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Beating Goliath: Generation Of NoveL, Integrated and Internationally Harmonised Approaches for Testing Metabolism Disrupting Compounds

Objective

GOLIATH addresses the work programme topic ‘SC1-BHC-27-2018: New testing and screening methods to identify endocrine disrupting chemicals (EDCs)’ by focussing on one of the most urgent regulatory needs, namely the lack of methods for testing EDCs that disrupt metabolism – chemicals collectively referred to as ‘metabolism disrupting chemicals’ (MDCs). MDCs are natural and anthropogenic chemicals that have the ability to promote metabolic changes that can ultimately result in obesity, diabetes and/or fatty liver in humans. GOLIATH will generate the world’s first integrated approach to testing and assessment (IATA) specifically tailored to MDCs. With a focus on the main cellular targets of metabolic disruption – hepatocytes, pancreatic endocrine cells, myocytes and adipocytes - GOLIATH will develop new methods and optimise existing methods that span the entire adverse outcome pathway (AOP) spectrum, using in silico predictive modelling and high throughput screening, (pre-)validated ready-to-use in vitro assays and optimised in vivo toxicity testing guidelines. GOLIATH will provide key information on the endocrine mode of action by which MDCs disrupt metabolic pathways and induce adverse effects on human health by incorporating multi-omics technologies, and translating results from in vitro and in vivo assays to adverse metabolic health outcomes in humans at real life exposures. Given the importance of international acceptance of the developed test methods for regulatory use, GOLIATH will link with ongoing initiatives of the OECD for test method (pre-)validation, IATA and AOP development. With a consortium comprised of world-leading experts in endocrinology, molecular biology, toxicology, epidemiology, test method development, validation and chemical regulation, GOLIATH will be pivotal in the development of an internationally harmonised strategy for testing MDCs, and help to reduce the worldwide rise in metabolic disorders that have reached ‘Goliathan’ proportions.

Field of science

  • /medical and health sciences/clinical medicine/endocrinology
  • /natural sciences/biological sciences/molecular biology
  • /medical and health sciences/clinical medicine/endocrinology/diabetes
  • /medical and health sciences/health sciences/epidemiology
  • /medical and health sciences/basic medicine/toxicology

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

UNIVERSITEIT UTRECHT
Address
Heidelberglaan 8
3584 CS Utrecht
Netherlands
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 268 269,88

Participants (14)

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
France
EU contribution
€ 798 786,25
Address
147 Rue De L'universite
75007 Paris Cedex 07
Activity type
Research Organisations
Department of Health
United Kingdom
EU contribution
€ 459 104,53
Address
Quarry House, Quarry Hill
LS2 7UE Leeds
Activity type
Research Organisations
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France
EU contribution
€ 1 077 695
Address
Rue De Tolbiac 101
75654 Paris
Activity type
Research Organisations
KAROLINSKA INSTITUTET
Sweden
EU contribution
€ 402 500
Address
Nobels Vag 5
17177 Stockholm
Activity type
Higher or Secondary Education Establishments
UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE
Spain
EU contribution
€ 672 862,50
Address
Avenida De La Universidad S-n
03202 Elche
Activity type
Higher or Secondary Education Establishments
AGENCE NATIONALE DE LA SECURITE SANITAIRE DE L ALIMENTATION DE L ENVIRONNEMENT ET DU TRAVAIL
France
EU contribution
€ 134 250
Address
14 Rue Pierre Et Marie Curie
94700 Maisons Alfort
Activity type
Research Organisations
LINKOPINGS UNIVERSITET
Sweden
EU contribution
€ 338 287,50
Address
Campus Valla
581 83 Linkoping
Activity type
Higher or Secondary Education Establishments
VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK N.V.
Belgium
EU contribution
€ 137 510
Address
Boeretang 200
2400 Mol
Activity type
Research Organisations
BRUNEL UNIVERSITY LONDON
United Kingdom
EU contribution
€ 261 946,25
Address
Kingston Lane
UB8 3PH Uxbridge
Activity type
Higher or Secondary Education Establishments
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
United Kingdom
EU contribution
€ 248 525
Address
Trinity Lane The Old Schools
CB2 1TN Cambridge
Activity type
Higher or Secondary Education Establishments
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
United States
EU contribution
€ 339 596,84
Address
Franklin Street 1111, 12 Floor
94607 Oakland Ca
Activity type
Higher or Secondary Education Establishments
BIOPREDIC INTERNATIONAL SARL
France
EU contribution
€ 243 750
Address
Parc D'activite De La Breteche Batiment A4
35760 Saint Gregoire
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HOFFMANN SEBASTIAN
Germany
EU contribution
€ 75 000
Address
Stembergring 15
33106 Paderborn
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UMEA UNIVERSITET
Sweden
EU contribution
€ 303 750
Address
Universitetomradet
901 87 Umea
Activity type
Higher or Secondary Education Establishments