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Accurate, Rapid, Robust and Economical diagnostic technoliogieS for Tuberculosis

Accurate, Rapid, Robust and Economical diagnostic technoliogieS for Tuberculosis

Objective

This visionary project addresses the key needs of patients, clinicians and the World Health Organisations stated deliverables of affordable, reliable and point-of-care molecular TB diagnostics, with the vision of removing the need for centralised facilities and offering remote primary care diagnosis coupled with telemetry for “cloud based” notification to ensure public health and surveillance interventions. The core technology deliverables will include: Rapid screening of TB infection (within 30 mins): We will develop low-cost portable optical devices and chemical molecular probes for accurate and rapid ‘triage tests’ to allow ‘no-wash’ detection of Mycobacteria ‘in-field’ in sputum at costs comparable with or lower than existing microscopy-based methods. This technology has the aim of replacing current sputum-based microscopy methods. Rapid molecular identification of drug resistance (within 2 hours): We will develop novel low-cost assays based on molecular methods that will allow accurate and rapid screening for the Mycobacterium tuberculosis complex in sputum and drug-resistant tuberculosis, thus providing rapid screening of at risk groups for TB as well as identification of drug resistance profiles. Biomarkers for early diagnosis and assessing treatment response: A higher risk element is the development of point-of-care diagnostics for quantification of microRNAs (that are known to be modulated during progression from latent to active TB and during treatment progression), directly from small blood samples. We will ensure that the technologies are economically viable in the context of resource poor settings – indeed the whole project will be driven by practical need and local resourcing constraints – NOT imposition. Thus it will require negligible initial costs for implementation, minimal training and expertise, with the running costs less than 1/10 th of current detection technologies, thereby addressing a key objective of the work program.
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Coordinator

THE UNIVERSITY OF EDINBURGH

Address

Old College, South Bridge
Eh8 9yl Edinburgh

United Kingdom

Activity type

Higher or Secondary Education Establishments

EU Contribution

€ 1 031 682,50

Participants (8)

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DESTINA GENOMICA

Spain

EU Contribution

€ 417 911

HERIOT-WATT UNIVERSITY

United Kingdom

EU Contribution

€ 592 452,50

UNIVERSITA DEGLI STUDI DI PADOVA

Italy

EU Contribution

€ 391 750

OPTOELETTRONICA ITALIA SRL

Italy

EU Contribution

€ 271 250

GENETIC ANALYSIS STRATEGIES SL

Spain

EU Contribution

€ 292 450

CENTRAL TUBERCULOSIS RESEARCH INSTITUTE OF RUSSIAN ACADEMY OF MEDICAL SCIENCES

Russia

INDIAN COUNCIL OF MEDICAL RESEARCHSOCIETY

India

SHANMUKHA INNOVATIONS PRIVATE LIMITED

India

Project information

Grant agreement ID: 825931

Status

Ongoing project

  • Start date

    1 January 2019

  • End date

    31 December 2020

Funded under:

H2020-EU.3.1.1.

  • Overall budget:

    € 4 438 898,75

  • EU contribution

    € 2 997 496

Coordinated by:

THE UNIVERSITY OF EDINBURGH

United Kingdom