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Accurate, Rapid, Robust and Economical diagnostic technoliogieS for Tuberculosis

Objective

This visionary project addresses the key needs of patients, clinicians and the World Health Organisations stated deliverables of affordable, reliable and point-of-care molecular TB diagnostics, with the vision of removing the need for centralised facilities and offering remote primary care diagnosis coupled with telemetry for “cloud based” notification to ensure public health and surveillance interventions. The core technology deliverables will include: Rapid screening of TB infection (within 30 mins): We will develop low-cost portable optical devices and chemical molecular probes for accurate and rapid ‘triage tests’ to allow ‘no-wash’ detection of Mycobacteria ‘in-field’ in sputum at costs comparable with or lower than existing microscopy-based methods. This technology has the aim of replacing current sputum-based microscopy methods. Rapid molecular identification of drug resistance (within 2 hours): We will develop novel low-cost assays based on molecular methods that will allow accurate and rapid screening for the Mycobacterium tuberculosis complex in sputum and drug-resistant tuberculosis, thus providing rapid screening of at risk groups for TB as well as identification of drug resistance profiles. Biomarkers for early diagnosis and assessing treatment response: A higher risk element is the development of point-of-care diagnostics for quantification of microRNAs (that are known to be modulated during progression from latent to active TB and during treatment progression), directly from small blood samples. We will ensure that the technologies are economically viable in the context of resource poor settings – indeed the whole project will be driven by practical need and local resourcing constraints – NOT imposition. Thus it will require negligible initial costs for implementation, minimal training and expertise, with the running costs less than 1/10 th of current detection technologies, thereby addressing a key objective of the work program.

Field of science

  • /medical and health sciences/health sciences/public and environmental health
  • /medical and health sciences/basic medicine/pharmacology and pharmacy/drug resistance
  • /medical and health sciences/clinical medicine/pneumology/tuberculosis

Call for proposal

H2020-SC1-2018-Single-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

THE UNIVERSITY OF EDINBURGH
Address
Old College, South Bridge
EH8 9YL Edinburgh
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 1 031 682,50

Participants (8)

DESTINA GENOMICA SLNE
Spain
EU contribution
€ 417 911
Address
Avenida De La Innoaci0n 1 Edificio Bic
18100 Granada
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
HERIOT-WATT UNIVERSITY
United Kingdom
EU contribution
€ 592 452,50
Address
Riccarton
EH14 4AS Edinburgh
Activity type
Higher or Secondary Education Establishments
UNIVERSITA DEGLI STUDI DI PADOVA
Italy
EU contribution
€ 391 750
Address
Via 8 Febbraio 2
35122 Padova
Activity type
Higher or Secondary Education Establishments
OPTOELETTRONICA ITALIA SRL
Italy
EU contribution
€ 271 250
Address
Via Vienna 8
38121 Trento
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
GENETIC ANALYSIS STRATEGIES SL
Spain
EU contribution
€ 292 450
Address
Calle Santa Justa 5 6 B
03300 Orihuela Alicante
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRAL TUBERCULOSIS RESEARCH INSTITUTE OF RUSSIAN ACADEMY OF MEDICAL SCIENCES
Russia
EU contribution
€ 0
Address
Yauzskay Alley 2
107564 Moscow
Activity type
Research Organisations
INDIAN COUNCIL OF MEDICAL RESEARCHSOCIETY
India
EU contribution
€ 0
Address
Ansari Nagar
110029 New Delhi
Activity type
Research Organisations
SHANMUKHA INNOVATIONS PRIVATE LIMITED
India
EU contribution
€ 0
Address
Kaggadasapura 101 Kk Towers Balaji Layout Cv Raman Nagar
560093 Bengaluru
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)