Project description
Unveiling the regulation of autophagy in plants
Autophagy, or self-eating, is a cellular process for the degradation of unnecessary or damaged cell components. Autophagy has conserved biological functions across different species including development, cellular homeostasis and stress responses. The EU-funded SSHelectPhagy project focusses on the role of autophagy induced by nutrient deprivation in plant cells and aims to study how this process is regulated by sulphide. Scientists will provide important information on the mechanism of autophagy regulation associated with many aspects of plant life and fitness, including seedling establishment, plant development, stress resistance, metabolism and reproduction.
Objective
The researcher will address the contribution of sulfide to regulation of selective autophagy in plants through persulfidation. This fellowship will be carried out at Iowa State University under the supervision of Prof. Bassham. The researcher will return to the European host, the University of Seville for 12 months under the supervision of Dr.Gotor at the Institute of Plant Biochemistry and Photosynthesis (IBVF). This project aims at understanding of selective autophagy regulation by sulfide in plants. Autophagy has conserved functions in development, cellular homeostasis, and stress responses from yeast to plants and mammals. In plants, autophagy is critically important in many aspects of plant life, including seedling establishment, plant development, stress resistance, metabolism and reproduction. It contributes to intracellular homeostasis in cells by selectively degrading aggregated proteins, damaged mitochondria, ribosomes, toxic macromolecules, and pathogens to prevent toxicity. This selective autophagy is mediated by the binding of adaptor proteins, which links a cargo targeted for degradation to the autophagosome machinery. An increasing number of targets for selective autophagy under different stress conditions have emerged in recent years, but the underlying mechanisms of their regulation are still so far unknown. Hydrogen sulfide (H2S) acts as an inhibitor of autophagy induced by nutrient deprivation and its mechanism has been proposed to be through persulfidation of specific targets. Several autophagy (ATG)-related proteins have been identified as modified by persulfidation in previous studies. The overall aim of this project is to shed light to the role of sulfide in the regulation of selective autophagy, mainly of mitochondria and ER, through persulfidation, and to broaden the range of plant targets for mitophagy and reticulophagy that are signaled by sulfide.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins
- natural sciences biological sciences cell biology
- natural sciences biological sciences zoology mammalogy
- medical and health sciences basic medicine physiology homeostasis
- natural sciences biological sciences botany
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-GF - Global Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2018
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
41004 Sevilla
Spain
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.