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Peripheral nerve Gel-based Orientation (Peripheral nerve injury recovery using Gel-based Orientation)

Objective

PeriGO will pave the way for the commercialization of a unique, first-of-its-kind peripheral nerve repair strategy, as it uses an injectable, biocompatible hydrogel that provides directionality through controlled guiding elements. The properties of the smart material Anisogel, initially developed in the ERC project ANISOGEL to repair spinal cord injuries, provide a sophisticated, superior alternative for peripheral nerve regeneration. The final product can be injected inside a bridging blood vessel or artificial hollow tube after implantation to direct regenerating nerves across the injury site.
PeriGO comprises 3 key actions to advance a quick translation from the laboratory to the clinic: We will 1) establish a sterilization method and a packaging/application system to perform pre-clinical tests, 2) verify the handling and efficacy of the product in a rat sciatic nerve lesion model in cooperation with the Department of Plastic Surgery at the University Hospital in Aachen, and 3) complete a market study and business plan to bring PeriGO into the clinic.
PeriGO addresses essential issues associated with peripheral nerve regeneration. While the current Gold Standard of autologous nerve grafts creates a secondary defect, artificial bridging approaches for nerve gaps only reconnect short distances (< 3 cm) with marginal success. Features absent in the commercially available nerve tubes are guiding structures, controlled degradation, and a good interface with the damaged nerve stumps. The PeriGO platform will overcome these limitations as the material 1) is injected as a liquid to make a tight contact with the injured nerve and to adapt to the shape of the bridging tube before gelation, 2) provides unidirectional guiding elements, and 3) presents tunable material properties with tunable degradation kinetics adjusting to the length of the nerve gap. With PeriGO, we will thus establish the next generation of nerve repair strategies.
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Host institution

DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV

Address

Forckenbeckstrasse 50
52074 Aachen

Germany

Activity type

Research Organisations

EU Contribution

€ 120 000

Beneficiaries (2)

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DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV

Germany

EU Contribution

€ 120 000

UNIVERSITAETSKLINIKUM AACHEN

Germany

EU Contribution

€ 30 000

Project information

Grant agreement ID: 842452

Status

Ongoing project

  • Start date

    1 August 2019

  • End date

    31 January 2021

Funded under:

H2020-EU.1.1.

  • Overall budget:

    € 150 000

  • EU contribution

    € 150 000

Hosted by:

DWI LEIBNIZ-INSTITUT FUR INTERAKTIVE MATERIALIEN EV

Germany