Project description DEENESFRITPL Exploring the role of brain 'connectivity' to predict and treat stroke The potential effects of stroke include loss of mobility speech and lack of focus. The timely identification of anatomical predictors of brain recovery may significantly reduce the burden of these deficits on patients and their environment, contributing to the discovery of new targets for treatments. Brain lesions do not just disable but also disconnect brain areas which, once deprived of their input or output, can no longer subserve behaviour and cognition. The EU-funded DISCONNECTOME project will explore the relationship between brain disconnection and neuropsychological syndromes. More specifically, it will investigate if measures of brain 'connectivity' can be translated into a personalised medicine approach, focussing upon rehabilitation and improving the prediction of symptom recovery. Show the project objective Hide the project objective Objective Every year a brain stroke will impair approximately 2 million Europeans. Notwithstanding recent progress, many of these individuals will have persistent cognitive deficits, impacting their personality, degrading their quality of life and preventing their return to work. Early identification of anatomical predictors of brain recovery may significantly reduce the burden of these deficits on patients, their families and wider society, while also leading to the discovery of new targets for treatments.I have pioneered the development of imaging techniques that allow for the exploration of the relationship between brain disconnection and neuropsychological syndromes. With these tools, I aim to demonstrate that the structural organisation of the human brain's connections is the common denominator supporting functional specialisation and, when damaged, neuropsychological disorders.Building on my expertise, I plan to (1) establish an atlas mapping the function of white matter for the entire human brain, (2) fractionate the stroke population according to disconnection profiles, (3) predict neuropsychological symptoms based on disconnection profiles, and (4) characterise and manipulate the fine biology involved in the disconnection recovery.In so doing, this project will introduce a paradigm shift in the relationship between brain structure, function and behavioural/cognitive disorders. I will deliver a comprehensive biological model of the neurocircuitry that supports neuropsychological syndromes, which will gather the modular organisation of primary idiotypic functions with the integrative organisation of highly associative levels of functions. In the long term, this project will allow me to determine if measures of brain ‘connectivity’ can be translated into advanced standard procedures that provide for a more personalised medicine, that focuses upon rehabilitation and improving the prediction of symptom recovery, while providing new targets for pharmacological treatment. Fields of science medical and health sciencesclinical medicinephysiotherapymedical and health scienceshealth sciencespersonalized medicinemedical and health sciencesbasic medicineneurologystroke Keywords Neuropsychology Cognition Stroke Associationism Connections Model Connectivity White matter Programme(s) H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC) Main Programme Topic(s) ERC-2018-COG - ERC Consolidator Grant Call for proposal ERC-2018-COG See other projects for this call Funding Scheme ERC-COG - Consolidator Grant Host institution CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS Net EU contribution € 1 456 973,95 Address RUE MICHEL ANGE 3 75794 Paris France See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 456 973,95 Beneficiaries (2) Sort alphabetically Sort by Net EU contribution Expand all Collapse all CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS France Net EU contribution € 1 456 973,95 Address RUE MICHEL ANGE 3 75794 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 1 456 973,95 INSTITUT DU CERVEAU ET DE LA MOELLE EPINIERE France Net EU contribution € 542 227,05 Address BOULEVARD DE L'HOPITAL 47 75013 Paris See on map Region Ile-de-France Ile-de-France Paris Activity type Research Organisations Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 542 227,05
