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BovReg - Identification of functionally active genomic features relevant to phenotypic diversity and plasticity in cattle

Objective

Despite the revolution in functional genome analysis a wide gap in understanding associations between the (epi)genome and complex phenotypes of interest currently remains and impedes efficient use of annotated genomes for precision breeding. The BovReg consortium will provide a comprehensive map of functionally active genomic features in cattle and how their (epi)genetic variation in beef and dairy breeds translates into phenotypes. This constitutes key knowledge for biology-driven genomic prediction needed by scientific and industry livestock communities. The BovReg brings together a critical mass of experts in ruminant research and beyond encompassing bioinformatics, molecular and quantitative genetics, animal breeding, reproductive physiology, ethics and social science. Our 20 partners from the EU, Canada and Australia form a global interdisciplinary team, which builds on previous and running national and EU-funded projects and many established industry cooperations. In BovReg we will generate functional genome data based on FAANG core assays from representative bovine tissues and newly established cell lines covering different ontological stages and phenotypes applying novel bioinformatic pipelines. We will establish detailed knowledge on traits related to robustness, health and biological efficiency in cattle. Data, knowledge and protocols will be deposited in European biological archives, aiming to set up and maintain a knowledge hub and establish gold standards. Long-term availability of data and targeted dissemination and communication activities are guaranteed by EMBL-EBI, FAANG and EAAP. Our biology-driven genomic prediction tools will integrate biological knowledge on regulatory genomic variation into genomic selection schemes for local and global cattle populations. This improved knowledge will be useful for re-focussing cattle production, fully taking into account societal awareness, environmental and animal-welfare aspects and bio-efficiency.
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Coordinator

LEIBNIZ-INSTITUT FUR NUTZTIERBIOLOGIE

Address

Wilhelm-Stahl-Allee 2
18196 Dummerstorf

Germany

Activity type

Research Organisations

EU Contribution

€ 999 837,50

Participants (18)

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FUNDACIO CENTRE DE REGULACIO GENOMICA

Spain

EU Contribution

€ 299 943,75

INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

France

EU Contribution

€ 492 000

DIAGENODE

Belgium

EU Contribution

€ 107 125

UNIVERSITE DE LIEGE

Belgium

EU Contribution

€ 1 026 625

EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH

Switzerland

EU Contribution

€ 336 875

STICHTING WAGENINGEN RESEARCH

Netherlands

EU Contribution

€ 227 187,50

AARHUS UNIVERSITET

Denmark

EU Contribution

€ 336 750

LUONNONVARAKESKUS

Finland

EU Contribution

€ 267 850

INSTYTUT GENETYKI I HODOWLI ZWIERZAT POLSKIEJ AKADEMII NAUK

Poland

EU Contribution

€ 181 437,50

UNIVERSITEIT UTRECHT

Netherlands

EU Contribution

€ 188 832,50

EUROPEAN MOLECULAR BIOLOGY LABORATORY

Germany

EU Contribution

€ 538 120

FEDERAZIONE EUROPEA DI ZOOTECNICA

Italy

EU Contribution

€ 125 250

THE GOVERNORS OF THE UNIVERSITY OF ALBERTA UNIVERSITY OF ALBERTA

Canada

EU Contribution

€ 46 625

THE UNIVERSITY OF EDINBURGH

United Kingdom

EU Contribution

€ 435 422,74

MARTIN-LUTHER-UNIVERSITAET HALLE-WITTENBERG

Germany

EU Contribution

€ 82 312,50

UNIVERSITE DE LIMOGES

France

EU Contribution

€ 136 062,50

FACULDADE DE MEDICINA VETERINARIA

Portugal

EU Contribution

€ 120 849,38

EDINETHICS LIMITED

United Kingdom

EU Contribution

€ 44 352,96

Project information

Grant agreement ID: 815668

Status

Ongoing project

  • Start date

    1 September 2019

  • End date

    31 August 2023

Funded under:

H2020-EU.3.2.1.1.

H2020-EU.3.2.3.1.

  • Overall budget:

    € 6 033 458,83

  • EU contribution

    € 5 993 458,83

Coordinated by:

LEIBNIZ-INSTITUT FUR NUTZTIERBIOLOGIE

Germany