Project description DEENESFRITPL A life support system for extremely preterm new-borns A large proportion of survivors among extremely preterm new-borns (<28 weeks) face lifelong disabilities associated with cardiovascular, neurological, breathing and metabolic problems. Current approach involves initiation of organ functions but the lungs and gut in preterm organs are not suited for such interventions. The EU-funded consortium will design and develop a totally new system of care for these new-borns by recreating ex vivo innate foetal cardiorespiratory physiological conditions. The system will include an artificial placenta with oxygen and nutrients exchange, continuous non-invasive monitoring of foetal parameters, foetal manikin for simulation of the new-born and corresponding computational modelling. An interdisciplinary team of academia and industry partners have joined forces to demonstrate the functionality of the system in a proof-of-principle. Show the project objective Hide the project objective Objective Every year, 800.000 babies are born extremely preterm (EP; <28 weeks of age) worldwide. A large proportion of survivors from this group of smallest infants face lifelong disabilities, including breathing, cardiac, neurological and metabolic problems. Current treatment requires the preterm initiation of body functions for which the respective organs are not prepared. This affects primarily the lungs which need to provide gas-exchange under air (i.e. oxygen-based mechanical ventilation), and the gut, which is needed for energy and nutrition. This approach causes major therapy-related morbidity such as bronchopulmonary dysplasia, necrotizing enterocolitis and germinal matrix bleeding. The Perinatal Life Support (PLS) consortium envisions a medical device that can support the safe development of EP infants outside the womb by preserving the innate fetal cardiorespiratory physiology ex vivo, with the following enabling technologies:1. A liquid-based environment with oxygen and nutrient exchange using an ´artificial placenta´; 2. Continuous and non-invasive monitoring of fetal parameters such as heart rate and oxygenation;3. Computational models for fast and objective clinical decision support based on physiological data input;4. A fetal manikin that can accurately simulate EP infants in an intensive care setting.The PLS project will be carried out by an interdisciplinary group of academia and industry with experience in modelling, monitoring, engineering, obstetrics and neonatology. The technology underlying PLS is applicable to conditions where ex vivo life support is required e.g. organ perfusion, regeneration and transplantation. The integrated system will allow major progress towards translation for an urgent medical need, where new solutions are lacking as preclinical models are inadequate and clinical trials not feasible. Innovative simulation technology will enable technical validation of PLS, with demonstration of functionality in a final Proof-of-Principle. Fields of science medical and health sciencesclinical medicineobstetricsmedical and health scienceshealth sciencesnutritionmedical and health sciencesbasic medicinephysiologymedical and health sciencesclinical medicinetransplantation Keywords life support premature baby fetus neonatology intensive care organs simulation mathematical models vitals monitoring manikin artificial placenta liquid ventilation clinical translation Programme(s) H2020-EU.1.2. - EXCELLENT SCIENCE - Future and Emerging Technologies (FET) Main Programme H2020-EU.1.2.1. - FET Open Topic(s) FETOPEN-01-2018-2019-2020 - FET-Open Challenging Current Thinking Call for proposal H2020-FETOPEN-2018-2020 See other projects for this call Sub call H2020-FETOPEN-2018-2019-2020-01 Funding Scheme RIA - Research and Innovation action Coordinator TECHNISCHE UNIVERSITEIT EINDHOVEN Net EU contribution € 792 500,00 Address GROENE LOPER 3 5612 AE Eindhoven Netherlands See on map Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 792 500,00 Participants (4) Sort alphabetically Sort by Net EU contribution Expand all Collapse all UNIVERSITAETSKLINIKUM AACHEN Germany Net EU contribution € 831 943,75 Address Pauwelsstrasse 30 52074 Aachen See on map Region Nordrhein-Westfalen Köln Städteregion Aachen Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 831 943,75 LIFETEC GROUP BV Netherlands Net EU contribution € 451 875,00 Address KENNEDYPLEIN 11 5611 ZS Eindhoven See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 451 875,00 POLITECNICO DI MILANO Italy Net EU contribution € 400 000,00 Address PIAZZA LEONARDO DA VINCI 32 20133 Milano See on map Region Nord-Ovest Lombardia Milano Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 400 000,00 NEMO HEALTHCARE BV Netherlands Net EU contribution € 399 812,50 Address DE RUN 4630 5504 DB Veldhoven See on map SME The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed. Yes Region Zuid-Nederland Noord-Brabant Zuidoost-Noord-Brabant Activity type Private for-profit entities (excluding Higher or Secondary Education Establishments) Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 399 812,50