Project description
Investigating the link between gut microbiota and the blood brain barrier
The blood brain barrier (BBB) is central to brain homeostasis as it regulates the selective transport of nutrients and other solutes to the brain. Emerging evidence suggests that the gut microbiota has a role in BBB function with changes in composition being linked to neurodevelopmental disorders such as autism or attention deficit hyperactivity disorder. With this in mind, scientists of the EU-funded NeuroVascOme project plan to investigate how early life microbiota perturbations affect neurovascular development and brain homeostasis later in life. Results will shed light on the role of modern society-induced stress, increasing antibiotic administration and caesarean delivery methods on neurovascular development.
Objective
The prenatal and early postnatal life are particularly vulnerable phases for brain development, during which essential neurodevelopmental processes occur. One such vital process is the development of the neurovascular unit resulting in the formation of blood brain barrier (BBB), which is the gateway regulating access of the external milieu to the brain. Concomitant with the postnatal BBB development, the maturation of our resident gut microbiota also occurs during this sensitive period of early life. Altered gut microbial composition has been shown to affect BBB function and is increasingly being linked to adverse health outcomes including neurodevelopmental disorders, such as autism or attention deficit hyperactivity disorder. However, an exact mechanistic understanding of how this early life alteration in microbiota composition leads to brain dysfunction is not known. The NeuroVascOme project aims to investigate the link between early life microbiota perturbations and neurovascular development, which in turn is crucial for brain homeostasis. And more precisely, how are the different disruptors of microbiome in early life impacting the neurovascular/BBB integrity, thereby predisposing the organism to health deficits in later life. This is especially relevant for our modern-day society wherein early life microbiome disruptions caused by increased stress, antibiotic administration and caesarean delivery methods are widely prevalent. In accordance with the aims of the MSCA fellowships, NeuroVascOme project will greatly aid my career development by providing first rate training in academic and industry settings that will enhance my research skillset, foster my managerial abilities and strengthen my professional network. Additionally, public, industry, and scientific audiences will be informed about the outcomes of the project through a dissemination strategy that will aim to promote the role of early life environment in shaping mental health.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- natural sciences biological sciences microbiology
- medical and health sciences basic medicine physiology homeostasis
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
T12 YN60 Cork
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.