Project description
Mapping Wnt signalling pathway components in Drosophila model
Wnt proteins are secreted glycoproteins that drive the Wnt signalling pathway which controls cell proliferation, differentiation and growth. Mutations in this pathway are often associated with colorectal and breast cancer. The aim of the EU-funded TWSCC project is to apply techniques used in cell biology to map the trafficking of Wnt pathway components in normal cells and to find if the routes are altered in cancers, thus providing their proliferative capacity. The research will involve generating new reagents and bioinformatic analyses to find lead candidates to perform a genetic screen in Drosophila melanogaster. The objective of this project is to combine high-resolution imaging and genetic perturbations to visualise Wnt component trafficking in vivo in both normal and cancer cells.
Objective
The Wnt cascade is an evolutionary conserved pathway that controls cell proliferation, differentiation and growth. Although mutations to this pathway are commonly associated with certain cancers (e.g. colorectal/breast cancer), other mechanisms that control Wnt activity, e.g. its intracellular trafficking regulation, has not received significant attention in the past. The objective of this fellowship is to use my existing knowledge of cell biology to map the trafficking routes that Wnt components take in normal cells, and to test if these routes are altered in cancers to sustain their proliferative capacity. This project will combine bioinformatic analysis to find lead candidates to further investigate in the model organism Drosophila melanogaster. By generating novel fly strains and using high-resolution imaging, I aim to advance our understanding on how Wnt components are trafficked in vivo.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences genetics mutation
- medical and health sciences clinical medicine oncology
You need to log in or register to use this function
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
-
H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
See all projects funded under this programme -
H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
See all projects funded under this programme
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
See all projects funded under this funding scheme
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2019
See all projects funded under this callCoordinator
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
69120 Heidelberg
Germany
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.