Project description
Gut barrier models to study the translocation of microplastics and nanoplastics
With the current abundance of microplastics and nanoplastics in our environment, the exposure of humans and animals is unavoidable. It has been established that microplastics and nanoplastics are present in the drinking water and the ocean, and are inevitably consumed by aquatic organisms and mammals. The impact on humans remains to be explored, including the capacity of those substances to translocate through the gut barrier. The EU-funded MIGMIPS project aims to develop a novel in vitro approach to quantify the translocation of microplastics and nanoplastics through the gut epithelial barrier. To that end, scientists will work towards creating micro-physiological models that closely resemble the gut barrier as well as methods for the detection and characterisation of plastics inside biological tissues and liquids.
Objective
The presence of micro and nanoplastics is now documented in the drinking water, ocean, marine invertebrates and fishes. Their toxicity for humans is still mostly unknown, as well as their capacity to translocate through the gut barrier, especially since it depends strongly on the size, shape, surface state, material of these plastics, which are strongly heterogeneous or even contaminated by organic or toxic compounds. In this project, I propose to develop new in-vitro systems in order to quantify the translocation of environmental nano and microplastics obtained from plastic wastes, through the gut epithelial barrier. This proposal includes the development of 1- microphysiological systems mimicking that barrier and 2- detection techniques for the characterization of micro and nanoplastics directly inside biological tissues (Raman-SERS, SEM, AFM, confocal microscopy) or in liquids.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 Paris
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.