Objective
"I propose to determine the complete ""structure-dynamics-function"" picture of the photoinduced processes happening in heteroaromatic bimolecules in solution under ultraviolet (UV) light exposure.
Whilst light induced processes are essential to life (vision and light harvesting processes such as photosynthesis are two prominent examples), they can also be extremely detrimental, as is the case for UV radiation damage of DNA. Nucleobases readily absorb UV light, accessing an electronically excited state and potentially triggering a structural rearrangement, leading to photolesions. Still, these “building blocks” of life present an inherent resistance (""photostability"") to these processes, compared to other classes of molecules. This property, far from being comprehensively understood, is believed to be linked with how efficiently these molecules release the excess energy of the photo-prepared electronically excited state through non-radiative relaxation pathways (conical intersections - CIs).
The location and topography of CIs can be extremely environment-dependent, particularly in a polar solvent like water: it is thus the interplay between solute and solvent that governs the dynamics and, thus, biological function of these molecules.
I propose to perform few-fs resolved deep ultraviolet (DUV) pump - extreme ultraviolet (XUV) probe time resolved photoelectron spectroscopy (TRPES) studies on heteroaromatic biomolecules in solution, with the goal of determining their solvent dependent structural changes (location of the relevant CIs) and the early stages (first tens of fs) of the related ultrafast relaxation pathways.
A deeper understanding of the relationship between the structure, dynamics and function of heteroaromatic biomolecules in solution under UV exposure could have multiple implications, from the more basic improvement of auxiliary protections against UV (e.g. better sunscreens) to more advanced materials- and bio- engineering based on nature mimicking."
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules
- natural sciences physical sciences molecular and chemical physics
- natural sciences physical sciences optics spectroscopy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2020
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
20133 Milano
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.