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Role of selective autophagy processes in regulating the glucose tolerance of carnivorous fish: seeking greater replacement of fishmeal by vegetal ingredients in aquafeeds

Project description

Improved non-fishmeal nutrients in aquafeeds

The EU-funded MEAL fish project will investigate chaperone-mediated autophagy (CMA) and endosomal microautophagy (eMI) in farmed fish to determine their role in nutrient utilisation and metabolism. Elucidating the role of CMA and eMI in the control of carbohydrate metabolism will help explain the diverse physiological processes that can ultimately affect fish production, including nutrition and growth. The research fellow will study their application in aquaculture for the promotion of the use of non-fishmeal nutrients in aquafeeds, focusing on an important commercial species, the rainbow trout (Oncorhynchus mykiss). This project will ultimately contribute to EU food security and sustainable aquaculture; moreover, it will help the EU maintain its position as a world leader in the field of fish nutrition.

Objective

The overarching goal of MEAL fish is to further understand the role of chaperone-Mediated autophagy (CMA) and Endosomal microautophagy (eMI) in AquacuLture fish, and to determine their relative contribution to nutrient utilization and metabolism. Deciphering the role of CMA and eMI in the control of carbohydrate metabolism will contribute to shed light on diverse physiological processes that can ultimately affect fish production, including nutrition and growth. During this trainee-development focused project, the fellow, through his interactions with the supervisor and the partners (H. Wodrich, and A. Herpin, from the stellar French research institutions CNRS and INRAE, respectively), will acquire diverse state-of-the-art skills that significantly enhance his scientific and technical knowledge. The mentor (I. Seiliez, UMR1419 INRAE NuMeA) is an internationally recognized leader in autophagy, fish metabolism and genomics and provides an excellent training environment for the applicant, an experienced researcher (ER) and emerging young leader in fish biology research. It is noteworthy the novelty and originality of the project, which proposes to gain insights on the function of a recently discovered process in fish, CMA, together with the barely known eMI, and to study its applied scope in aquaculture for the promotion of the use of non-fishmeal nutrients in aquafeeds. The project focuses on an important commercial species of the European aquaculture, the rainbow trout (O. mykiss). The European research competitiveness will be continuously enhanced throughout the project by the superior training of the ER, the interaction between multidisciplinary researchers, and translating for commercial use of the derived new knowledge on the regulation of CMA and eMI and its contribution to fish production. This project will ultimately contribute to the EU food sustainability, economy, employment and maintenance of its status as a group of high-level-knowledge countries.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)

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Call for proposal

(opens in new window) H2020-MSCA-IF-2020

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Coordinator

INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Net EU contribution
€ 196 707,84
Address
147 RUE DE L'UNIVERSITE
75007 Paris
France
Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
Links
Total cost
€ 196 707,84