Project description
Making metabolomics study simpler and smarter
Metabolomics refers to the study of small molecules in biological samples. The study offers a real-time snapshot of an organism’s metabolic state. This has huge potential for understanding health and disease, yet the field faces significant challenges including inconsistent results, difficulty in identifying important markers, and combining data from different studies. With the support of the Marie Skłodowska-Curie Actions programme, the HUMAN project will bring together experts from complementary disciplines to train 10 early-stage researchers in innovative metabolomics techniques. The focus will be on studying how the body’s metabolism changes during intense exercise, using methods such as dried blood spots for easier sampling. The goal is to create better sample preparation methods, standardise metabolomics practices, and make the field more accessible.
Objective
Metabolomics provides a real-time view of the metabolic state of the examined samples. The past decade the field showed strong growth, however limitations intrinsic to the field hinder further application in epidemiology level. Key obstacles include: variety of analyte molecular structures, slow marker identification, large differences in concentrations, poor validation, incomplete combination of data from different analyses and fragmentation of research. The consortium brings together scientists from different complementary disciplines and sectors to collaborate and set a research training network, combining infrastructure experience, knowledge and skills. The research scope is to identify the source of problems that hinder development, and recommend measures to overcome these. Training through
research will promote a new generation of omics researchers. Networking, joining forces via secondments will enhance research productivity transfer of knowledge. The project will train 10 ESRs in work-packages aiming toward improvement of design of experiment, harmonization of analytical methods, improved Data Mining and biochemical pathway analysis and translational research. Application will be in the study of blood metabolome of exhaustive physical exercise.
We aim to study sample stability & preparation (including blood and alternative forms such as dried blood spots), biomarker identification, exploitation of multiple datasets, promote standard procedures, develop robust pipelines, develop and implement machine searchable notations of metadata, central database for data storage, compare datasets, automate cross-laboratory data combination, develop novel algorithms for multidimensional data mining and reconstruct biochemical pathways. The overall goal is to train the ESRs in cutting edge metabolomics research and at the same time provide proof of concept of democratizing metabolomics by the use of patient centric sampling.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
This project's classification has been human-validated.
Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-DN - HORIZON TMA MSCA Doctoral Networks
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Call for proposal
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Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2021-DN-01
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546 36 THESSALONIKI
Greece
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Participants (6)
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28040 Madrid
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85764 Neuherberg
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07743 JENA
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39100 Bolzano
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75007 Paris
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71800 Siilinjarvi
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Partners (16)
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Participation ended
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WA15 9AF HALE ALTRINCHAM
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152 32 CHALANDRI
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546 23 TSESSALONIKI
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145 65 Athens
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80333 Muenchen
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70211 KUOPIO
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31400 Toulouse
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07745 Jena
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171 45 Solna
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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28359 Bremen
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10115 Berlin
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SW7 2AZ London
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81671 Munchen
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Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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546 42 THESSALONIKI
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
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MK8 0AB Milton Keynes
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The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.
Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.
Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SK9 4AX Wilmslow Cheshire
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The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.