Project description
Stroke treatment with virtual simulations
Acute Ischemic Stroke (AIS) is a leading cause of death and disability worldwide, with 1.12 million cases reported in the EU in 2017. The condition arises from a blockage in brain blood vessels due to clots, leading to impaired blood flow. Despite the advances brought by Endovascular Stroke Treatment (EVT), which has been revolutionary since 2012, nearly 65 % of patients experience post-treatment complications. Supported by the Marie Skłodowska-Curie Actions programme, the VThrombectomy project will develop a sophisticated in silico framework to simulate EVT procedures. By creating virtual models based on patient-specific data, including flexible blood vessels and dynamic clot properties, VThrombectomy aims to improve the understanding of mechanical forces. This approach promises to refine EVT techniques and reduce complications for stroke patients.
Objective
Acute Ischemic Stroke (AIS) is the leading cause of death and disability globally. In 2017, 1.12 million people suffered from a stroke in European Union, and it is expected to increase by 27% in 2047. The AIS occurred due to insufficient blood supply to the brain from blockage of blood clots or thrombus. Restoration of the blood supply to the brain is the primary objective of medical treatment after the detection of AIS. This can be done using recently developed minimally invasive Endovascular Stroke Treatment (EVT). The introduction of EVT to clinical trials in 2012 revolutionised stroke treatment, but nearly 65% of patients face post-treatment complications and disabilities. Such complications show a huge void in improving the EVT treatment using in silico and in vitro approaches.
The current project (VThrombectomy) proposes a framework for mimicking the EVT procedure using in silico approach. The EVT consists of three major components: stent retriever, blood clot, and flexible blood vessel. Mimicking these components for numerical simulations and understanding the mechanical forces involved is the primary objective of this project. In which, Patient-based images will be used to mimic the cerebral arterial network, and mechanical properties of thrombus will be replicated using patient-based clot stress-strain data. The development of a virtual thrombectomy procedure will take place by solving these components using a multiphysics approach in a coupled way. The major limitations involved in the previous studies were the use of an ideal cerebral artery model with rigid walls and the absence of blood flow during EVT. VThrombectomy proposes to address these limitations by the inclusion of patient-specific flexible blood vessels with flowing blood. Parametric analysis of EVT using in silico approach can dive deep into the treatment and improves our understanding of the mechanical forces involved, which results in improved and efficient devices to retrieve the clot.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences basic medicine neurology stroke
- natural sciences computer and information sciences computational science multiphysics
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Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
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Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
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Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
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(opens in new window) HORIZON-MSCA-2022-PF-01
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20133 Milano
Italy
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