Objective
While recent work has begun to shed light on the microbiota, which includes the trillions of bacteria and phages that inhabit our body, our understanding of its evolution over the course of human history is limited. To answer research questions regarding the development of the human microbiota over time, researchers have begun to sequence ancient DNA from well-preserved fecal and dental samples to understand their bacterial community composition. However, an important group of the microbiota, bacterial viruses (or bacteriophages), which play a large role in influencing bacterial community structure and can affect human health and disease, are often understudied in these ancient samples. Here, we propose ARCHAIC (bActeRiophage in the anCient HumAn mICrobiome), a project which aims to answer key questions regarding these important viral populations in these ancient samples. Using an integrative and collaborative approach, we will use sequencing data of ancient paleofeces and dental calculus to study the oral and gut microbiome from a variety of time periods. This novel work will allow us to develop a pipeline to identify viruses in ancient samples and answer the question - do ancient bacteriophage populations resemble modern ones? In addition, by identifying phages in these ancient samples, we will be able to probe the sequencing data for insights on phage evolution, the development of bacterial defense systems against phages, as well as reconstruct ancient phage genomes to identify novel phage/host pairs. ARCHAIC will move the field of phage biology forward by identifying phages in these relatively understudied ancient samples and will have results that will be applicable to the fields of bacterial evolution, anthropology, and bioinformatics.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- humanities history and archaeology history
- natural sciences biological sciences microbiology virology
- natural sciences biological sciences genetics DNA
- social sciences sociology anthropology
- natural sciences biological sciences microbiology bacteriology bacteriomes
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
T12 YN60 Cork
Ireland
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.