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A general bismuth-based platform for the catalytic construction of carbon–nitrogen bonds and beyond.

Objective

The amino moiety is a fundamental functional group with essential functions across the chemical and life sciences, including agrochemical and pharmaceutical research and manufacture, polymer chemistry, and biochemistry. Therefore, there is a well-acknowledged need for new and more sustainable methods to construct C-N bonds. Most procedures for C-N bond formation rely on the use of toxic and expensive transition metal catalysts, which are notoriously impeded by undesired -hydride elimination and/or poor site selectivity. Consequently, the search for new and more sustainable catalytic paradigms in synthesis has shifted towards the main group elements. Bismuth was recently demonstrated to moonlight both as a noble or first row transition metal, displaying reactivity in 1-electron and 2-electron processes at will. This dichotomy in reactivity of low-valent Bi complexes could potentially be crucial in addressing the long-standing issues encountered in CN bond formation. Thus, ClaN-Bi aims to discover and develop new catalytic CN cross-coupling reactions to generate both aliphatic and aromatic amines by exploiting the new Bi(I)/(II)/(III) redox platform.

Fields of science (EuroSciVoc)

Keywords

Programme(s)

Topic(s)

Funding Scheme

HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships

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Call for proposal

(opens in new window) HORIZON-MSCA-2022-PF-01

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Coordinator

MAX PLANCK INSTITUT FUER KOHLENFORSCHUNG
Net EU contribution
€ 173 847,36
Address
KAISER WILHELM PLATZ 1
45470 Muelheim An Der Ruhr
Germany
Region
Nordrhein-Westfalen Düsseldorf Mülheim an der Ruhr
Activity type
Research Organisations
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Total cost
No data