Objective
Though it has long been known that activated lymphoid cells upregulate insulin receptors, the functional relevance of insulin signalling in immune cells has only recently begun to be explored. This includes the recent finding that insulin-stimulated activation in the PI3K/Akt/mTOR promotes immunometabolic reprogramming of T cells, thereby promoting antigen-specific immunity. Similarly, in liver cells, insulin receptors have been shown to translocate to the nucleus where they participate in regulating genes involved in viral response and epitope presentation. What's more, various lines of evidence have implicated inulin signalling in the development of coagulopathies, via its effect on the expression of cytokines, complement and clotting factors, whiles also affecting platelets and endothelium. Taken together, these and other observations implicate an under-appreciated immune-regulatory function of insulin. Yet, even basic questions regarding insulin signalling in immune cells (e.g. do T cells develop insulin resistance?) are currently unknown. In the proposed study, we will investigate the effect of insulin signalling in immune and non-immune cells to evaluate the impact of insulin signalling on these immune-related functions. Firstly, we will leverage publicly available proteome and transcriptome data to re-interrogate these data sets from an immunological perspective. Complimenting these activities, we will also conduct detailed cell culture experiments to evaluate the effect of (a) does and (b) duration of insulin on the release of clotting factors, cytokines and complement, as well as immune cell activation and polarization. Finally, we will conduct a vaccine trial on a rodent model to evaluate the effect of insulin on vaccine efficacy. Beyond T1D and T2D, these findings will also impact diabetic care in organ transplant, gestational diabetes and the development of pre-eclampsia, immunotherapies, and intensive insulin therapy in critical/intensive care.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- medical and health sciences clinical medicine endocrinology diabetes
- natural sciences biological sciences genetics RNA transcriptomes
- medical and health sciences basic medicine pharmacology and pharmacy pharmaceutical drugs vaccines
- medical and health sciences basic medicine immunology immunotherapy
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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HORIZON.1.2 - Marie Skłodowska-Curie Actions (MSCA)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
HORIZON-TMA-MSCA-PF-EF - HORIZON TMA MSCA Postdoctoral Fellowships - European Fellowships
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) HORIZON-MSCA-2022-PF-01
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3000 Leuven
Belgium
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.